Author: Mahmoud A. Hassanien
Publisher: Springer Science & Business Media
ISBN: 9048123356
Category : Science
Languages : en
Pages : 538
Book Description
The book contains the contributions at the NATO Study Institute on Exposure and Risk Assessment of Chemical Pollution – Contemporary Methodology, which took place in Sofia – Borovetz, Bulgaria, July 1–10, 2008. Rapid advances in mathematics, computer science and molecular biology and chemistry have lead to the development in of a new branch of toxicology called Computational Toxicology. This emerging field is addressing the estimation and prediction of exposure risk and effects of chemicals based on experimental data, measured concentration and biological mechanisms and computational models of biological systems. Mathematical models are also being used to predict the fate and transport of substances in the environment. Because this area is still in its infancy, there has been limited application from governmental agencies to regulating controllable processes, such as registration of new chemicals, determination of estimated exposure and risk based limits and maximum acceptable concentrations in different compartments of the environment – ambient air, waters, soil and food products. However, this is soon to change as the ability to collect, analyze and interpret the required information is becoming increasingly more efficient and cost effective. Full implementation of the new processes have to involve education on both part of the experimentalists who are generating the data and the models, and the risk assessors who will use them to better protect human health and the environment.
Exposure and Risk Assessment of Chemical Pollution - Contemporary Methodology
Author: Mahmoud A. Hassanien
Publisher: Springer Science & Business Media
ISBN: 9048123356
Category : Science
Languages : en
Pages : 538
Book Description
The book contains the contributions at the NATO Study Institute on Exposure and Risk Assessment of Chemical Pollution – Contemporary Methodology, which took place in Sofia – Borovetz, Bulgaria, July 1–10, 2008. Rapid advances in mathematics, computer science and molecular biology and chemistry have lead to the development in of a new branch of toxicology called Computational Toxicology. This emerging field is addressing the estimation and prediction of exposure risk and effects of chemicals based on experimental data, measured concentration and biological mechanisms and computational models of biological systems. Mathematical models are also being used to predict the fate and transport of substances in the environment. Because this area is still in its infancy, there has been limited application from governmental agencies to regulating controllable processes, such as registration of new chemicals, determination of estimated exposure and risk based limits and maximum acceptable concentrations in different compartments of the environment – ambient air, waters, soil and food products. However, this is soon to change as the ability to collect, analyze and interpret the required information is becoming increasingly more efficient and cost effective. Full implementation of the new processes have to involve education on both part of the experimentalists who are generating the data and the models, and the risk assessors who will use them to better protect human health and the environment.
Publisher: Springer Science & Business Media
ISBN: 9048123356
Category : Science
Languages : en
Pages : 538
Book Description
The book contains the contributions at the NATO Study Institute on Exposure and Risk Assessment of Chemical Pollution – Contemporary Methodology, which took place in Sofia – Borovetz, Bulgaria, July 1–10, 2008. Rapid advances in mathematics, computer science and molecular biology and chemistry have lead to the development in of a new branch of toxicology called Computational Toxicology. This emerging field is addressing the estimation and prediction of exposure risk and effects of chemicals based on experimental data, measured concentration and biological mechanisms and computational models of biological systems. Mathematical models are also being used to predict the fate and transport of substances in the environment. Because this area is still in its infancy, there has been limited application from governmental agencies to regulating controllable processes, such as registration of new chemicals, determination of estimated exposure and risk based limits and maximum acceptable concentrations in different compartments of the environment – ambient air, waters, soil and food products. However, this is soon to change as the ability to collect, analyze and interpret the required information is becoming increasingly more efficient and cost effective. Full implementation of the new processes have to involve education on both part of the experimentalists who are generating the data and the models, and the risk assessors who will use them to better protect human health and the environment.
Public Health Risk Assessment for Human Exposure to Chemicals
Author: Kofi Asante-Duah
Publisher: Springer
ISBN: 9402410392
Category : Medical
Languages : en
Pages : 600
Book Description
This book provides a concise, yet comprehensive overview of the many facets relating to human health risk assessments in relation to chemical exposure problems. It presents some very important tools and methodologies that can be used to address chemical exposure and public health risk management problems in a consistent, efficient, and cost-effective manner. On the whole, the book represents a collection and synthesis of the principal elements of the risk assessment process that may be used to more effectively address issues pertaining to human exposures to chemicals found in modern societies. This also includes an elaboration of pertinent risk assessment concepts and techniques/methodologies for performing human health risk assessments. Written for both the novice and the experienced, the subject matter of this book is an attempt at offering a simplified and systematic presentation of public health risk assessment methods and application tools – all these facilitated by a layout that will carefully navigate the user through the major processes involved. A number of illustrative example problems are interspersed throughout the book, in order to help present the book in an easy-to-follow, pragmatic manner.
Publisher: Springer
ISBN: 9402410392
Category : Medical
Languages : en
Pages : 600
Book Description
This book provides a concise, yet comprehensive overview of the many facets relating to human health risk assessments in relation to chemical exposure problems. It presents some very important tools and methodologies that can be used to address chemical exposure and public health risk management problems in a consistent, efficient, and cost-effective manner. On the whole, the book represents a collection and synthesis of the principal elements of the risk assessment process that may be used to more effectively address issues pertaining to human exposures to chemicals found in modern societies. This also includes an elaboration of pertinent risk assessment concepts and techniques/methodologies for performing human health risk assessments. Written for both the novice and the experienced, the subject matter of this book is an attempt at offering a simplified and systematic presentation of public health risk assessment methods and application tools – all these facilitated by a layout that will carefully navigate the user through the major processes involved. A number of illustrative example problems are interspersed throughout the book, in order to help present the book in an easy-to-follow, pragmatic manner.
The Practice of Consumer Exposure Assessment
Author: Gerhard Heinemeyer
Publisher: Springer Nature
ISBN: 3319961489
Category : Medical
Languages : en
Pages : 613
Book Description
This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety. The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.
Publisher: Springer Nature
ISBN: 3319961489
Category : Medical
Languages : en
Pages : 613
Book Description
This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety. The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.
Exposure Assessment in Occupational and Environmental Epidemiology
Author: Mark J. Nieuwenhuijsen
Publisher: OUP Oxford
ISBN: 0191015687
Category : Medical
Languages : en
Pages : 298
Book Description
Set against a background of growing public, media and political concern about occupational and environmental health issues, and a scientific need to better understand and explain the effects of pollutants on human health, this book is a unique resource. Contributions from an expert panel of international practitioners provide a comprehensive reference on the state of the art methods and applications in the field of occupational and environmental pollution and the adverse health effects, particularly the exposure assessment in epidemiological studies. Risks associated with occupational and environmental exposure are generally small, but the exposed population, and hence the population attributable risk, may be large. To detect small risk, the exposure assessment needs to be very refined. Exposure assessment is the study of the distribution and determinants of potentially hazardous agents, and includes the estimation of intensity, duration and frequency of exposure, the variation in these indices and their determinants. The aim of this book is to develop an understanding and knowledge of exposure assessment methods and their application to substantive issues in occupational and environmental epidemiology. The emphasis is on methodological principles and good practice. It is focused on exposure assessment in both occupational and environmental epidemiology since there are many similarities but also some interesting differences. The book outlines the basic principles of exposure assessment, and examines the current status and research questions in the exposure assessment of occupational and environmental epidemiological studies of allergens, particulate matter, chlorination disinfection by-products, agricultural pesticides and radiofrequencies. The book will be of interest to all concerned with exposure assessment and epidemiology. It will be a valuable source for undergraduate and postgraduate courses in exposure assessment, occupational hygiene, environmental science, epidemiology, toxicology, biostatistics, occupational and environmental health, health risk assessment and related disciplines and a useful resource of reference for policy makers and regulators.
Publisher: OUP Oxford
ISBN: 0191015687
Category : Medical
Languages : en
Pages : 298
Book Description
Set against a background of growing public, media and political concern about occupational and environmental health issues, and a scientific need to better understand and explain the effects of pollutants on human health, this book is a unique resource. Contributions from an expert panel of international practitioners provide a comprehensive reference on the state of the art methods and applications in the field of occupational and environmental pollution and the adverse health effects, particularly the exposure assessment in epidemiological studies. Risks associated with occupational and environmental exposure are generally small, but the exposed population, and hence the population attributable risk, may be large. To detect small risk, the exposure assessment needs to be very refined. Exposure assessment is the study of the distribution and determinants of potentially hazardous agents, and includes the estimation of intensity, duration and frequency of exposure, the variation in these indices and their determinants. The aim of this book is to develop an understanding and knowledge of exposure assessment methods and their application to substantive issues in occupational and environmental epidemiology. The emphasis is on methodological principles and good practice. It is focused on exposure assessment in both occupational and environmental epidemiology since there are many similarities but also some interesting differences. The book outlines the basic principles of exposure assessment, and examines the current status and research questions in the exposure assessment of occupational and environmental epidemiological studies of allergens, particulate matter, chlorination disinfection by-products, agricultural pesticides and radiofrequencies. The book will be of interest to all concerned with exposure assessment and epidemiology. It will be a valuable source for undergraduate and postgraduate courses in exposure assessment, occupational hygiene, environmental science, epidemiology, toxicology, biostatistics, occupational and environmental health, health risk assessment and related disciplines and a useful resource of reference for policy makers and regulators.
Contaminants in Drinking and Wastewater Sources
Author: Manish Kumar
Publisher: Springer Nature
ISBN: 9811545995
Category : Technology & Engineering
Languages : en
Pages : 447
Book Description
This volume takes a multidisciplinary approach to study and evaluate the global human vulnerability to the exposure of contaminants of emerging concern (CECs) in the natural environment. It provides a comprehensive resource on structurally diverse groups of chemical compounds that have adverse effects on the aquatic environment. It explores the global strength, environmental status, chemical risk assessment and management strategies of CECs with relevant modern techniques. The principle focus is on concurrent emerging water quality issues. It defines the impacts of the environmental exposure of trace concentrations of CECs and/or their metabolites and discusses possible technological advances to combat the emerging pollutants. It will be useful to researchers, multi-stakeholder expert groups, policymakers, and graduate students.
Publisher: Springer Nature
ISBN: 9811545995
Category : Technology & Engineering
Languages : en
Pages : 447
Book Description
This volume takes a multidisciplinary approach to study and evaluate the global human vulnerability to the exposure of contaminants of emerging concern (CECs) in the natural environment. It provides a comprehensive resource on structurally diverse groups of chemical compounds that have adverse effects on the aquatic environment. It explores the global strength, environmental status, chemical risk assessment and management strategies of CECs with relevant modern techniques. The principle focus is on concurrent emerging water quality issues. It defines the impacts of the environmental exposure of trace concentrations of CECs and/or their metabolites and discusses possible technological advances to combat the emerging pollutants. It will be useful to researchers, multi-stakeholder expert groups, policymakers, and graduate students.
Risk Assessment of Chemicals: An Introduction
Author: C.J. van Leeuwen
Publisher: Springer Science & Business Media
ISBN: 1402061013
Category : Science
Languages : en
Pages : 706
Book Description
At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources, emissions, distribution and fate processes for the estimation of exposure of plant and animal species in the environment and humans exposed via the environment, consumer products, and at the workplace. The coverage describes the basic principles and methods of risk assessment within their legislative frameworks (EU, USA, Japan and Canada).
Publisher: Springer Science & Business Media
ISBN: 1402061013
Category : Science
Languages : en
Pages : 706
Book Description
At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources, emissions, distribution and fate processes for the estimation of exposure of plant and animal species in the environment and humans exposed via the environment, consumer products, and at the workplace. The coverage describes the basic principles and methods of risk assessment within their legislative frameworks (EU, USA, Japan and Canada).
Risk Management of Chemicals in the Environment
Author: Hans M. Seip
Publisher: Springer Science & Business Media
ISBN: 1468456040
Category : Science
Languages : en
Pages : 236
Book Description
The Council of the North Atlantic Treaty Organization (NATO) established the "Committee on the Challenges of Modern Society" (CCMS) in 1969. The CCMS was charged with developing meaningful environmental and social programmes for solving existing problems and developing long-range goals for environmental protection. In 1983, at the Fall Plenary of the CCMS, the Norwegian delegate Dr. H.C. Christensen, proposed a Pilot Study on "Risk Management of Chemicals in the Environment". A draft proposal, written by Dr. Kari Kveseth of the Center for Industrial Research in Oslo, was presented. Dr. Christensen also informed the participants at the meeting that Norway was willing to act as the Pilot Country. The project was initially planned for 3 years, but it was later extended through 1987. The inaugural meeting was held in Oslo in April 1984 with participants from Denmark, Greece, France and Italy, in addition to representatives from several Norwegian institutions. The attendees concluded that a Pilot Study, as delineated in the draft proposal, would be useful, and it was decided to work out a detailed project plan based on the proposal.
Publisher: Springer Science & Business Media
ISBN: 1468456040
Category : Science
Languages : en
Pages : 236
Book Description
The Council of the North Atlantic Treaty Organization (NATO) established the "Committee on the Challenges of Modern Society" (CCMS) in 1969. The CCMS was charged with developing meaningful environmental and social programmes for solving existing problems and developing long-range goals for environmental protection. In 1983, at the Fall Plenary of the CCMS, the Norwegian delegate Dr. H.C. Christensen, proposed a Pilot Study on "Risk Management of Chemicals in the Environment". A draft proposal, written by Dr. Kari Kveseth of the Center for Industrial Research in Oslo, was presented. Dr. Christensen also informed the participants at the meeting that Norway was willing to act as the Pilot Country. The project was initially planned for 3 years, but it was later extended through 1987. The inaugural meeting was held in Oslo in April 1984 with participants from Denmark, Greece, France and Italy, in addition to representatives from several Norwegian institutions. The attendees concluded that a Pilot Study, as delineated in the draft proposal, would be useful, and it was decided to work out a detailed project plan based on the proposal.
Environmental Heavy Metal Pollution and Effects on Child Mental Development
Author: Lubomir I. Simeonov
Publisher: Springer
ISBN: 9400702531
Category : Science
Languages : en
Pages : 344
Book Description
Heavy metals can be emitted into environment by both natural and anthropogenic sources, mainly mining and industrial activity. Human exposure occurs through all environmental media. Infants are more susceptible to the adverse effects of exposure. Increasing attention is now being paid to the mental development of children exposed to heavy metals. The purpose of this book is to evaluate the existing knowledge on intellectual impairment in children exposed to heavy metals in their living environment and to identify the research needs in order to obtain a clearer picture of the situation in countries and regions at risk, in which the economy is closely related to metallurgy and heavy metals emission, and to recommend a strategy for human protection. In greater detail the main objectives could be formulated as follows: to review the principal sources of single, and complex mixtures of, heavy metal pollutants in the environment; to identify suitable methodology for chemical analyses in the environment and in humans; to evaluate the existing methods for measuring mental impairment, including their reliability and validity; to recommend a standard testing protocol to be used in future research; to assess the future role of environmental heavy metal pollution in countries and regions at risk and its effects on children’s neurological development; to recommend a prevention strategy for protecting children’s health and development.
Publisher: Springer
ISBN: 9400702531
Category : Science
Languages : en
Pages : 344
Book Description
Heavy metals can be emitted into environment by both natural and anthropogenic sources, mainly mining and industrial activity. Human exposure occurs through all environmental media. Infants are more susceptible to the adverse effects of exposure. Increasing attention is now being paid to the mental development of children exposed to heavy metals. The purpose of this book is to evaluate the existing knowledge on intellectual impairment in children exposed to heavy metals in their living environment and to identify the research needs in order to obtain a clearer picture of the situation in countries and regions at risk, in which the economy is closely related to metallurgy and heavy metals emission, and to recommend a strategy for human protection. In greater detail the main objectives could be formulated as follows: to review the principal sources of single, and complex mixtures of, heavy metal pollutants in the environment; to identify suitable methodology for chemical analyses in the environment and in humans; to evaluate the existing methods for measuring mental impairment, including their reliability and validity; to recommend a standard testing protocol to be used in future research; to assess the future role of environmental heavy metal pollution in countries and regions at risk and its effects on children’s neurological development; to recommend a prevention strategy for protecting children’s health and development.
Methods in Chemical Process Safety
Author:
Publisher: Academic Press
ISBN: 0128218258
Category : Technology & Engineering
Languages : en
Pages : 454
Book Description
Methods in Chemical Process Safety, Volume Four focuses on the process of learning from experience, including elements of process safety management, human factors in the chemical process industries, and the regulation of chemical process safety, including current approaches. Users will find this book to be an informative tool and user manual for process safety for a variety of professionals with this new release focusing on Advanced Methods of Risk Assessment and Management, Logic Based Methods for Dynamic Risk Assessment, Bayesian Methods for Dynamic Risk Assessment, Data Driven Methods, Rare Event Risk Assessment, Risk Management and Multi Criteria, and much more. Helps acquaint the reader/researcher with the fundamentals of process safety Provides the most recent advancements and contributions on the topic from a practical point-of-view Presents users with the views/opinions of experts in each topic Includes a selection of authors who are leading researchers and/or practitioners for each given topic
Publisher: Academic Press
ISBN: 0128218258
Category : Technology & Engineering
Languages : en
Pages : 454
Book Description
Methods in Chemical Process Safety, Volume Four focuses on the process of learning from experience, including elements of process safety management, human factors in the chemical process industries, and the regulation of chemical process safety, including current approaches. Users will find this book to be an informative tool and user manual for process safety for a variety of professionals with this new release focusing on Advanced Methods of Risk Assessment and Management, Logic Based Methods for Dynamic Risk Assessment, Bayesian Methods for Dynamic Risk Assessment, Data Driven Methods, Rare Event Risk Assessment, Risk Management and Multi Criteria, and much more. Helps acquaint the reader/researcher with the fundamentals of process safety Provides the most recent advancements and contributions on the topic from a practical point-of-view Presents users with the views/opinions of experts in each topic Includes a selection of authors who are leading researchers and/or practitioners for each given topic
Environmental Security Assessment and Management of Obsolete Pesticides in Southeast Europe
Author: Lubomir I. Simeonov
Publisher: Springer
ISBN: 9400764618
Category : Science
Languages : en
Pages : 475
Book Description
The present work is a fine contribution to the broad field of environmental security in the context of risk assessment and management of obsolete pesticides for the region of Southeast Europe. The purpose of this book is to evaluate the existing knowledge of improper disposal of obsolete pesticides in the region, to estimate the associated impact on environmental health, and to develop recommendations to mitigate or eliminate threats posed to the environment, biodiversity and human life. The issues discussed in the book include: reviews of the transport and fate of pesticides and associated contaminated materials in different environmental media and identification of the principal sources, emission routes and patterns of environmental pollution with pesticides; a recognition of the most suitable methods for environmental sampling analysis and sample preparation; an evaluation of the current methods and techniques for chemical and mass analysis of environmental and biological samples and discussion of the metrological and quality aspects of trace analyses; a characterization of the environmental and human health impacts of pesticide pollution, the health effects associated with acute and chronic exposure and the use of epidemiological data for risk assessment; a revision of the existing chemical safety regulations and strategies for protection and management of obsolete pesticide stocks; a survey of the international conventions, directives and standards concerning pesticide use.
Publisher: Springer
ISBN: 9400764618
Category : Science
Languages : en
Pages : 475
Book Description
The present work is a fine contribution to the broad field of environmental security in the context of risk assessment and management of obsolete pesticides for the region of Southeast Europe. The purpose of this book is to evaluate the existing knowledge of improper disposal of obsolete pesticides in the region, to estimate the associated impact on environmental health, and to develop recommendations to mitigate or eliminate threats posed to the environment, biodiversity and human life. The issues discussed in the book include: reviews of the transport and fate of pesticides and associated contaminated materials in different environmental media and identification of the principal sources, emission routes and patterns of environmental pollution with pesticides; a recognition of the most suitable methods for environmental sampling analysis and sample preparation; an evaluation of the current methods and techniques for chemical and mass analysis of environmental and biological samples and discussion of the metrological and quality aspects of trace analyses; a characterization of the environmental and human health impacts of pesticide pollution, the health effects associated with acute and chronic exposure and the use of epidemiological data for risk assessment; a revision of the existing chemical safety regulations and strategies for protection and management of obsolete pesticide stocks; a survey of the international conventions, directives and standards concerning pesticide use.