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Author: Nobel Symposium Publisher: Elsevier ISBN: 0444816585 Category : Medical Languages : en Pages : 429
Book Description
This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.
Author: Nobel Symposium Publisher: Elsevier ISBN: 0444816585 Category : Medical Languages : en Pages : 429
Book Description
This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.
Author: Lars Svennerholm Publisher: Springer Science & Business Media ISBN: 1468478443 Category : Medical Languages : en Pages : 556
Book Description
This volume records the proceedings of an International Symposium on The Structure and Function of Gangliosides, held at Le Bischenberg, Alsace, France, in April 23-27, 1979. The meeting was convened to get a comprehensive view of the immense activity that had occurred in the field since the previous conference on gangliosides held at Mont Sainte-Odile, ~lsace, France, in April 1973. At a conference on Enzymes of Lipid Metabolism held at the same place in April, 1977, several of the participants from the first ganglioside conference in 1973 met again. All previous participants agreed that the first meeting with its many frank and stimulating lectures, round tables and informal discussions had been of tremendous importance for the activity in the field and led to many personal contacts and a warm friendship among the ganglioside researchers. The success of the first meeting must be ascribed largely to one single man, PAUL MANDEL. Therefore, we decided to dedicate the next ganglioside conference to hirn and I was given the privilege to arrange the meeting together with him and staff members at Centre de Neurochirnie, Strasbourg. The Symposium on The Structure and Function of Gangliosides was arranged to honour PAUL MANDEL for his unique and never failing efforts to promote and strengthen international col laboration in all fields of neurochemistry.
Author: Cheorl-Ho Kim Publisher: Springer Nature ISBN: 9811558159 Category : Medical Languages : en Pages : 223
Book Description
This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
Author: Hinrich Rahmann Publisher: Springer Science & Business Media ISBN: 3642719325 Category : Science Languages : en Pages : 632
Book Description
The NATO Advanced Research Workshop on "Gangliosides and Modu lation of Neuronal Functions" was held at the University of Stutt gart-Hohenheim, Federal Republic of Germany, on October 20 - 24, 1986. About 70 participants from 10 countries presented papers on a wide range of topics all concerning the ganglioside theme. The content of the workshop consisted of the following chap ters: (1) Fundamentals for research on function of gangliosides; (2) Brain ganglioside metabolism; (3) Cell specific distribution and differentiation-related ex pression of brain gangliosides; (4) Gangliosides and neuronal plasticity; (5) Bio-medical potential of exogenous ganglioside application on neuronal function; and (6) Critical assessments on aspects of ganglioside therapy. The aim of the workshop was to sum up and discuss the present knowledge in the respective fields. Despite intensive research on gangliosides ever since Ernst Klenk discovered them in 1936, the biological function of. these amphiphilic, "sphinx-like" glycosphingo lipids remains elusive. Over the past few years, several thousands of articles on gangliosides have been published demonstrating very special properties of these glycolipids and their possible in volvement in diverse biological phenomena. As far as we know up to the present time, these properties may be due to particular physico-chemical attributes of these compounds, especially in com bination with calcium. The results obtained so far have shed light not only on pos sible functional roles of gangliosides with regard to cellular induction and organization, but have also unexpectedly opened up VI a whole new field of therapeutic applications for these compounds.
Author: Publisher: Academic Press ISBN: 0128123427 Category : Science Languages : en Pages : 480
Book Description
Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field. Contains accessible content that is ideal for students and researchers alike Written by leading authorities in the field
Author: Ajit Varki Publisher: CSHL Press ISBN: 9780879696818 Category : Medical Languages : en Pages : 694
Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Giuseppe Porcellati Publisher: Springer ISBN: 1461446147 Category : Science Languages : en Pages : 301
Book Description
The volume which is here presented reports all the lectures given at the International Satellite Meeting on Biochemical and Pharmacological Implications of Ganglioside Function held at Cor tona, Tuscany, Italy from 28 to 31 August, 1975. The Meeting was run just before the 5th International Congress of the International Society for Neurochemistry (Barcelona, 2-7 september, 1975) and was in fact organized on its frame. The general subject matter of gangliosides structure, biosyn thesis and degradation, of their functional role in neurochemistry, their pharmacological action and future potentialities, was deeply and throughly taken into consideration during the three-day Sympo sium, which was brilliantly directed and guided by Dr. L. Svenner holm. The meeting gave certainly, in our opinion, a valuable stimu lus to research workers interested in the biophysics, chemistry, biochemistry, physiology and pharmacology of gangliosides. The e ditors wish to express their thanhd to the speakers, the discussants, the Meeting Chairman, the section chairmen and to all the attendants who have taken part at the Symposium and who actively and deeply discussed the delivered lectures. Our final thank is also for Dr. Francesco della Valle, official representative of FIDIA Research Laboratories, Abano Terme, Padua, Italy, to whom we are grateful for his continuous and efficient support. The contribution of the Secretarial Staffs of both the v PREFACE Department of Biochemistry of Perugia University and FIDIA Labora tories to the editorial work is also gratefully acknowledged.
Author: Cheorl-Ho Kim Publisher: Springer Nature ISBN: 9811556520 Category : Medical Languages : en Pages : 135
Book Description
This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
Author: R.K. Margolis Publisher: Springer Science & Business Media ISBN: 147575955X Category : Science Languages : en Pages : 463
Book Description
This revised and renamed volume reflects a number of important changes in content and emphasis since this field was first surveyed in Complex carbohydrates of nervous tissue in 1979. A third of the chapters did not appear in the predecessor volume, and more than half have new authors. In this expand
Author: Nobel Symposium
Author: Nobel Symposium
Author: Lars Svennerholm
Author: Cheorl-Ho Kim
Author: Lars Svennerholm
Author: Hinrich Rahmann
Author: 
Author: Ajit Varki
Author: Giuseppe Porcellati
Author: Cheorl-Ho Kim
Author: R.K. Margolis