Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra PDF Download

Author: Giuseppe di Giovanni
Publisher: Springer Science & Business Media
ISBN: 3211926607
Category : Medical
Languages : en
Pages : 357

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Book Description
This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.

Author: Howard Federoff
Publisher:
ISBN: 9780801879975
Category : Dopamine
Languages : en
Pages : 0

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Book Description
Parkinson's Disease (PD), a progressive neurological disorder arising from degeneration of dopaminergic neurons in the substantia nigra region of the brain, is characterized by impairment of movement control. It progresses from symptoms such as tremor and muscular rigidity to total disability and death. This volume focuses on the dopaminergic system from a developmental perspective, with the objective of improving the understanding of how dopaminergic neurons form, how they mature and respond to genetic and environmental factors, and how they may be regenerated.

Author: V. Srinivasa Chakravarthy
Publisher: Springer
ISBN: 9811084947
Category : Technology & Engineering
Languages : en
Pages : 296

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Book Description
The book is a compendium of the aforementioned subclass of models of Basal Ganglia, which presents some the key existent theories of Basal Ganglia function. The book presents computational models of basal ganglia-related disorders, including Parkinson’s disease, schizophrenia, and addiction. Importantly, it highlights the applications of understanding the role of the basal ganglia to treat neurological and psychiatric disorders. The purpose of the present book is to amend and expand on James Houk’s book (MIT press; ASIN: B010BF4U9K) by providing a comprehensive overview on computational models of the basal ganglia. This book caters to researchers and academics from the area of computational cognitive neuroscience.

Author:
Publisher: Elsevier
ISBN: 0444642595
Category : Science
Languages : en
Pages : 484

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Book Description
The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Covers all key aspects of current research on 5-HT interaction with other neurotransmitters Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Author: Eva Maria Brandtner
Publisher: Bentham Science Publishers
ISBN: 1608057208
Category : Medical
Languages : en
Pages : 195

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Book Description
Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Author: Antonio Teixeira
Publisher: Oxford University Press
ISBN: 0197574319
Category : Medical
Languages : en
Pages : 449

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Book Description
Movement Disorders in Psychiatry examines the complex interface between movement disorders and psychiatry, addressing both specific movement disorders in psychiatry and behavioral syndromes associated with diseases categorized as movement disorders. This volume provides an overview of clinical definitions and pathophysiology of movement disorders and reviews specific movement disorders associated with drugs of abuse and psychotropic medications, including tardive dyskinesia, akathisia, and neuroleptic malignant syndrome. Further chapters discuss movement disorders seen in primary psychiatric disorders, such as autism and schizophrenia, as well as diseases with concurrent movement disorder and behavioral symptoms, such as Huntington's disease, Parkinson's disease, frontotemporal dementia, Tourette's syndrome, and autoimmune conditions. Movement Disorders in Psychiatry offers an in-depth perspective on movement disorders with treatment and practical management strategies for related challenges in clinical practice.

Author: Heinz Steiner
Publisher: Academic Press
ISBN: 008091215X
Category : Medical
Languages : en
Pages : 704

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Book Description
The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction. Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction Features a truly international cast of the preeminent researchers in the field Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases

Author: J.W. Langston
Publisher: IOS Press
ISBN: 1614993327
Category : Medical
Languages : en
Pages : 264

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Book Description
In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks

Author: Jahangir Moini
Publisher: Academic Press
ISBN: 0128174250
Category : Medical
Languages : en
Pages : 770

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Book Description
Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines. Written specifically for "mid-level" providers in the field of neurology Provides an up-to-date review of clinical neuroanatomy based on the latest guidelines Provides a logical, step-by-step introduction to neuroanatomy Offers hundreds of full-color figures to illustrate important concepts Highlights key subjects in "Focus On" boxes Includes Section Reviews at critical points in the text of each chapter

Author: Syed Amir Ashraf
Publisher: Elsevier
ISBN: 0443155291
Category : Technology & Engineering
Languages : en
Pages : 482

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Book Description
In recent years, there has been a global surge in the production and application of vitamins and pigments in food and pharmaceuticals industries, leading to draw the attention of scientific communities to develop novel strategies to cope with world demand. Microbial vitamins and carotenoids in food biotechnology: Novel source and potential applications allow the audience to understand the current status of the biotechnological approaches used for the production of vitamins and carotenoids from microorganisms. The title provides important insights to understand the molecular mechanisms involved in microbial biosynthesis of vitamins and carotenoids. The chapters, all written by leading researchers from academia, help to put forward all the latest advancement concerning the production and applications of microbial vitamins and carotenoids. The book also provides the sustainable alternative to chemically synthesized compound and presents the wide coverage for the most promising sources of vitamins and carotenoids in food and pharmaceutical industries. This is a complete and unique resource beneficial for the scientific communities as well as food science and nutrition research students. Thoroughly explores biotechnological approaches surrounding the production and application of microbial vitamins and carotenoids in food processing and manufacturing industries Covers the major portion of novel source and various biotechnological approaches used for the production of various types of vitamins and carotenoids from microorganisms and their applications in food industry Contains up-to-date information required for the formulations of new products or protocols for enhancing production of specific compounds