Calcium Transport and Intracellular Calcium Homeostasis PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Calcium Transport and Intracellular Calcium Homeostasis PDF full book. Access full book title Calcium Transport and Intracellular Calcium Homeostasis by Danielle Pansu. Download full books in PDF and EPUB format.
Author: Danielle Pansu Publisher: Springer Science & Business Media ISBN: 3642839770 Category : Science Languages : en Pages : 435
Book Description
The crucial role played by calcium as a cellular messenger has become increasingly evident, as has the recognition that cells spend much energy in maintaining the cytosolic concentration of this cation both constant and low. It is thought they do this to avoid precipitating phosphate, needed as a source of bond energy and to modulate protein structure. Moreover, since calcium that does enter the cell must be disposed with, processes that utilize calcium have evolved, e.g. secretion, contraction, signaling, to name just some. New knowledge concerning the processes of cellular calcium entry, extrusion and the fate of intracellular calcium has accumulated in recent years. Much has also been learned about calcium transport by and across epithelial cells. It seems logical to think that the processes of calcium entry, extrusion and intracellular handling are similar in all cells. We have therefore assembled in one volume overviews and research reports of transport and cellular calcium regulation so as to explore similarities and differences between cells that utilize calcium for metabolic purposes and those whose primary function is transport.
Author: Danielle Pansu Publisher: Springer Science & Business Media ISBN: 3642839770 Category : Science Languages : en Pages : 435
Book Description
The crucial role played by calcium as a cellular messenger has become increasingly evident, as has the recognition that cells spend much energy in maintaining the cytosolic concentration of this cation both constant and low. It is thought they do this to avoid precipitating phosphate, needed as a source of bond energy and to modulate protein structure. Moreover, since calcium that does enter the cell must be disposed with, processes that utilize calcium have evolved, e.g. secretion, contraction, signaling, to name just some. New knowledge concerning the processes of cellular calcium entry, extrusion and the fate of intracellular calcium has accumulated in recent years. Much has also been learned about calcium transport by and across epithelial cells. It seems logical to think that the processes of calcium entry, extrusion and intracellular handling are similar in all cells. We have therefore assembled in one volume overviews and research reports of transport and cellular calcium regulation so as to explore similarities and differences between cells that utilize calcium for metabolic purposes and those whose primary function is transport.
Author: Felix Bronner Publisher: Wiley-Liss ISBN: Category : Medical Languages : en Pages : 504
Book Description
Intracellular Calcium Regulation Editor Felix Bronner A notable development in biological research is the recent widespread interest in the role played by calcium in cellular metabolism. Calcium homeostasis has been studied intensively for many years and mechanisms by which calcium absorption, excretion and bone deposition are effected and regulated are beginning to be understood in detail. It now appears there may exist a parallel between the maintenance and regulation of intracellular and extracellular calcium. This volume presents up-to-date information on intracellular calcium regulation and thus provides a foundation for studies that aim to explore the relationship between intracellular and extracellular calcium metabolism. Intracellular Calcium Regulation examines in detail what happens to calcium inside the cell and offers authoritative discussions on such topics as: calcium fluxes: defining the role played by the plasma membrane in regulating the cellular calcium level, the application of tracer techniques to an analysis of the cellular calcium pool, the compartments making up the pool and the rates of exchange between compartments processes of calcium entry into the cell: describing entry into cells that do not fire action potentials, as well as three types of voltage-sensitive calcium channels, including their distribution, pharmacology, molecular properties and modulation organelles, such as the endoplasmic reticulum, the Golgi complex, lysosomes, or mitochondria and their role in regulating intracellular calcium levels the new, exciting field of calcium-binding or calcium modulated proteins, such as troponin-C, parvalbumin, S-100 proteins, calbindins, and calmodulin, as well as some novel calcium-binding proteins like the 42C and 42A proteins, calcyclin and caltractin calcium efflux: analyzing the role and function of the plasma membrane calcium pump and the Na+/Ca2+ exchanger, including the kinetics of ATP hydrolysis, how calcium transport and ATP hydrolysis are linked, the kinetics and properties of the sodium-calcium exchange, its regulation and role in such specialized cells as retinal rods and cardiac myocytes calcium transport as carried out by resting, stimulated and excitable cells with emphasis on activated phospholipase C, involvement of the G proteins and protein kinase C calcium transport as carried out by the specialized transport cells of intestine and kidney, entry via calcium channels, intracellular diffusion as facilitated by the calcium-binding proteins, and extrusion via the Ca-ATPase. Intracellular Calcium Regulation will be of interest to researchers and graduate students in the areas of biochemistry, biophysics, cell biology, nutrition, gastroenterology, nephrology and anatomy.
Author: J.R. Sotelo Publisher: Springer Science & Business Media ISBN: 1475795556 Category : Medical Languages : en Pages : 168
Book Description
When we began to organize the workshop "Calcium and Cellular Metabolism: Transport and Regulation" the goal we had in mind was to put together the knowledge of 2 several specialists on Ca + homeostasis, with various examples of cellular metabolisms 2 2 (such as protein synthesis), regulated by Ca + ions. Regarding the homeostasis of Ca + ions, we invited Ernesto Carafoli to write the first chapter as a general state-of-the-art introductory review. On the other hand, the other chapters are the contribution of different specialists on membrane calcium transport mechanisms, aiming to reunite at least in part the wide field of calcium homeostasis. We roughly try to group chapters that share similar subjects. The first group of chapters (Chapters 2 to 6), are mainly related to calcium channels. Thus, Chapter 2 by Rodolfo Llimis et a!. describes a new concept related to the dimen sions of the calcium action domain at the inner mouth of calcium channels in the squid gi ant synapse and its relationship to neurotransmitter release. Chapter 3 by Martin Morad et a!. informs us about new ways of identifying and measuring, by confocal microscopy, in dividual sites where calcium release occurs in ventricular myocytes. In the same group Osvaldo Uchitel and Eleonora Katz classify and evaluate the variety of calcium channels at the neuromuscular junction, in Chapter 4. Chapter 5 by Gustavo Brum et a!.
Author: Gary Fiskum Publisher: Springer Science & Business Media ISBN: 1468455982 Category : Medical Languages : en Pages : 613
Book Description
A widespread appreciation for the role that calcium plays in cell physiology and patho physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D. C. The participants in this unique meeting rep resented diverse fields of basic and clinical research, such as molecular physiology, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content of the proceedings of the symposium represents work in these and other areas of biomedical research. Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al 2 terations in cell Ca + homeostasis. The first section of the book is devoted to the transport mechanisms responsible for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling cell Ca + . Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels. The second section covers the exciting relationships between phosphoinositide metab 2 olism, signal transduction, and cell Ca + metabolism. This section begins with an eloquent overview by Professor Michael Berridge, who was the keynote speaker at the symposium and the recipient of the scientific merit award.
Author: Felix Bronner Publisher: CRC Press ISBN: 9780849301889 Category : Medical Languages : en Pages : 182
Book Description
Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects; several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide; and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions; one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated. Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.
Author: George Jr. Nichols Publisher: Elsevier ISBN: 0323146155 Category : Medical Languages : en Pages : 556
Book Description
Cellular Mechanisms for Calcium Transfer and Homeostasis presents the proceedings of the Workshop Conference on Cell Mechanisms for Calcium Transfer and Homeostasis, held at Portsmouth, New Hampshire on September 13–16, 1970. This book examines the ubiquity of the involvement of calcium in the function and structure of biological systems. Comprised of seven parts encompassing 26 chapters, this book starts with the ramifications of calcium and its various roles in the body’s economy. This text then discusses how calcium is absorbed by an active cation-oriented transport process. Other chapters explore the fundamental roles of calcium as a component of bone mineral, as well as in the control of cell replication and growth. This text also examines the structural organization of the nerve cell membrane. The final chapter presents data on calcium transport across cellular and subcellular membranes. This book is a valuable resource for biologists, cellular biologists, researchers, and students.
Author: Masayoshi Yamaguchi Publisher: ISBN: 9781629486048 Category : Science Languages : en Pages : 186
Book Description
The calcium metabolism in the living body is skillfully regulated through calcium-regulating hormones, including the parathyroid hormone, active vitamin D3 metabolite and calcitonin. The blood calcium concentration is ten thousand-fold compared with the levels in cells. Cells use extracellular calcium to regulate cell function efficiently. Intracellular calcium homeostasis is exactly regulated through the mechanism related to various calcium transport systems in cells. Signal transduction plays a pivotal role in cellular regulation. Calcium signaling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. Calcium regulates the activity of numerous calcium-dependent proteins including protein kinases, protein phosphatases, protease and other calcium-regulating factors involved in calcium signaling. Calcium signaling plays a pivotal role in the regulation of manifold cellular functions including cell proliferation, apoptosis and gene expression. This book focuses on recent topics in calcium signaling and its related diseases.
Author: Felix Bronner Publisher: Elsevier ISBN: 032315591X Category : Medical Languages : en Pages : 322
Book Description
Calcium and Phosphate Transport Across Biomembranes is a collection of papers presented at the 1981 Calcium and Phosphate Transport Across Biomembranes international workshop held in Vienna, Austria. Contributors from a wide range of disciplines explore the intracellular role of calcium and phosphate and their transport into and out of the body through the intestine and the kidney. In particular, they describe calcium movement in the cell and across the plasma membrane, along with phosphate transport into the cell, particularly, at the brush border. Organized into 10 sections encompassing 53 chapters, this collection begins with an overview of the mechanisms underlying the net movements of calcium in the cell and plasma membrane. The discussion then shifts to the crystal structure of calmodulin, the phosphate transport in the mitochondria, the mechanisms for calcium extrusion, the calcium uptake by brush border membranes, and the possible role of the mitochondria in intracellular calcium regulation. The book also introduces the discussion on mitochondrial calcium transport protein, polypeptide and amine hormone regulation of calcium fluxes, mechanism of secretion by cultured pituitary cells, and regulation of the tubular transport of phosphate. A chapter that assesses the effects of vitamin D and insulin on phosphate transport in the differentiating chick small intestine concludes the book. This collection of papers will be of interest to scientists, neurochemists, physiologists, pharmacologists, biochemists, gastroenterologists, nutritionists, and pathophysiologists.
Author: Danielle Pansu
Author: Danielle Pansu
Author: E. Carafoli
Author: Felix Bronner
Author: J.R. Sotelo
Author: Gary Fiskum
Author: Felix Bronner
Author: George Jr. Nichols
Author: Masayoshi Yamaguchi
Author: Felix Bronner
Author: Hermann Bader