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Author: J. M. W. Slack Publisher: CUP Archive ISBN: 9780521273299 Category : Science Languages : en Pages : 260
Book Description
This book is about the development of the animal embryo starting from the fertilised egg. The emphasis is on the problem of pattern formation: how cells in different regions of the embryo become programmed to form the various structures of the body in the correct relative positions.
Author: J. M. W. Slack Publisher: CUP Archive ISBN: 9780521273299 Category : Science Languages : en Pages : 260
Book Description
This book is about the development of the animal embryo starting from the fertilised egg. The emphasis is on the problem of pattern formation: how cells in different regions of the embryo become programmed to form the various structures of the body in the correct relative positions.
Author: J. M. W. Slack Publisher: Cambridge University Press ISBN: 9780521409438 Category : Science Languages : en Pages : 356
Book Description
The last ten years have shown a dramatic revolution in our understanding of early animal development. This new edition of the successful first edition describes the result of this revolution and explains how the body plan of an embryo emerges from the newly fertilised egg. The book starts with a critical discussion of embryological concepts and explains in simple terms the mathematics of cell states, morphogen gradients and threshold responses. The experimental evidence on the mechanism of regional specification in Xenopus, molluscs, annelids, ascidians as well as Caenorhabditis, the mouse, the chick and Drosophila is then discussed. The whole chapter devoted to the exciting developments in Drosophila provides a clear guide to the subject, including a new table outlining the developmentally important genes. The emphasis throughout is on conceptual clarity and unity: bringing together the mathematical models, embryological experiments and molecular biology into a single, comprehensive coherent account.
Author: Gabor Kovacs Publisher: Cambridge University Press ISBN: 1108668461 Category : Medical Languages : en Pages : 402
Book Description
This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.
Author: Lucy van de Wiel Publisher: NYU Press ISBN: 1479803626 Category : Social Science Languages : en Pages : 378
Book Description
Welcomed as liberation and dismissed as exploitation, egg freezing (oocyte cryopreservation) has rapidly become one of the most widely-discussed and influential new reproductive technologies of this century. In Freezing Fertility, Lucy van de Wiel takes us inside the world of fertility preservation—with its egg freezing parties, contested age limits, proactive anticipations and equity investments—and shows how the popularization of egg freezing has profound consequences for the way in which female fertility and reproductive aging are understood, commercialized and politicized. Beyond an individual reproductive choice for people who may want to have children later in life, Freezing Fertility explores how the rise of egg freezing also reveals broader cultural, political and economic negotiations about reproductive politics, gender inequities, age normativities and the financialization of healthcare. Van de Wiel investigates these issues by analyzing a wide range of sources—varying from sparkly online platforms to heart-breaking court cases and intimate autobiographical accounts—that are emblematic of each stage of the egg freezing procedure. By following the egg’s journey, Freezing Fertility examines how contemporary egg freezing practices both reflect broader social, regulatory and economic power asymmetries and repoliticize fertility and aging in ways that affect the public at large. In doing so, the book explores how the possibility of egg freezing shifts our relation to the beginning and end of life.
Author: Stanley Fields Publisher: MIT Press ISBN: 0262289008 Category : Science Languages : en Pages : 235
Book Description
How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
Author: Florence Louise Marlow Publisher: Morgan & Claypool Publishers ISBN: 161504051X Category : Family & Relationships Languages : en Pages : 221
Book Description
Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
Author: J. M. W. Slack Publisher: Cambridge University Press ISBN: 9780521409438 Category : Science Languages : en Pages : 0
Book Description
The past decade has seen a dramatic increase in our understanding of early animal development. The revised edition of this excellent book describes the results of this revolution and explains in detail how the body plan of an embryo emerges from a newly fertilized egg. The book starts with a critical discussion of embryological concepts, and with simple mathematics describes cell states, morphogen gradients, and threshold responses. The experimental evidence of the mechanisms of regional specification in vertebrates, insects, and selected invertebrates, namely frogs (Xenopus), mice, chicks, fruitflies (Drosophila), mollusks, ringed worms, sea squirts, and nematode worms (Caenorhabditis), is then discussed. The progress with Drosophila has been particularly impressive, and there is an entire chapter devoted to it that provides a clear guide to the subject and includes a new table of developmentally important genes. Throughout, the emphasis is on conceptual clarity and unity, and the book brings together mathematical models, embryological experiments, and molecular biology in a single comprehensible and coherent account.
Author: Institute of Medicine and National Research Council Publisher: National Academies Press ISBN: 0309041287 Category : Science Languages : en Pages : 370
Book Description
This book results from a study by a committee of the Institute of Medicine and the National Research Council's Board on Agriculture. The committee examined the scientific foundations of medically assisted conception and developed an agenda for basic research in reproductive and developmental biology that would contribute to advances in the clinical and agricultural practice of in vitro fertilization and embryo transfer. The volume also discusses some barriers to progress in research and ways of lowering them, and explains the scientific issues important to ethical decision making.
Author: J. M. W. Slack
Author: J. M. W. Slack
Author: Bruce Alberts
Author: J. M. W. Slack
Author: Gabor Kovacs
Author: Lucy van de Wiel
Author: Stanley Fields
Author: Florence Louise Marlow
Author: J. M. W. Slack
Author: J. M. W. Slack
Author: Institute of Medicine and National Research Council