Identifiability and Regression Analysis of Biological Systems Models PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Identifiability and Regression Analysis of Biological Systems Models PDF full book. Access full book title Identifiability and Regression Analysis of Biological Systems Models by Paola Lecca. Download full books in PDF and EPUB format.
Author: Paola Lecca Publisher: ISBN: 9783030412562 Category : Biochemistry Languages : en Pages : 90
Book Description
This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection. Although the main fields of application discussed in the book are biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to deal with problems such as determining the identifiability conditions, searching for an identifiable model, and conducting their own regression analysis and diagnostics without supervision. Featuring a wealth of real-world examples, exercises, and codes in R, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Readers should be familiar with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R.
Author: Paola Lecca Publisher: ISBN: 9783030412562 Category : Biochemistry Languages : en Pages : 90
Book Description
This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection. Although the main fields of application discussed in the book are biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to deal with problems such as determining the identifiability conditions, searching for an identifiable model, and conducting their own regression analysis and diagnostics without supervision. Featuring a wealth of real-world examples, exercises, and codes in R, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Readers should be familiar with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R.
Author: Paola Lecca Publisher: Springer Nature ISBN: 3030412555 Category : Medical Languages : en Pages : 90
Book Description
This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection. Although the main fields of application discussed in the book are biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to deal with problems such as determining the identifiability conditions, searching for an identifiable model, and conducting their own regression analysis and diagnostics without supervision. Featuring a wealth of real-world examples, exercises, and codes in R, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Readers should be familiar with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R.
Author: Corrado Priami Publisher: World Scientific ISBN: 1783266899 Category : Science Languages : en Pages : 432
Book Description
Modeling is fast becoming fundamental to understanding the processes that define biological systems. High-throughput technologies are producing increasing quantities of data that require an ever-expanding toolset for their effective analysis and interpretation. Analysis of high-throughput data in the context of a molecular interaction network is particularly informative as it has the potential to reveal the most relevant network modules with respect to a phenotype or biological process of interest. Analysis of Biological Systems collects classical material on analysis, modeling and simulation, thereby acting as a unique point of reference. The joint application of statistical techniques to extract knowledge from big data and map it into mechanistic models is a current challenge of the field, and the reader will learn how to build and use models even if they have no computing or math background. An in-depth analysis of the currently available technologies, and a comparison between them, is also included. Unlike other reference books, this in-depth analysis is extended even to the field of language-based modeling. The overall result is an indispensable, self-contained and systematic approach to a rapidly expanding field of science. Contents:Algorithmic Systems BiologySetting the ContextSystems and ModelsStatic Modeling TechnologiesDynamic Modeling TechnologiesLanguage-based ModelingDynamic Modeling ProcessSimulationPerspectives and ConclusionsAppendix A: Basic MathAppendix B: Probability and StatisticsAppendix C: Semantics of Modeling Languages Readership: Graduate students in computer science, physics, mathematics or engineering or biology-related fields who want to better understand how to develop and use models of biological systems. Practitioners in systems biology who want to understand algorithmic modeling and algorithmic systems biology. Key Features:The book jointly deals with static (statistical) and dynamic (simulation) technologies making it a strong reference for who wants to approach real systems biology problemsThe content of the book is the result of more than ten years application of the material in university courses and to industrial-level problems in systems pharmacology and systems nutritionThere is no reference work available for the field of language-based modeling that is studied in depth in this bookKeywords:Modeling;Simulation;Network Analysis;Systems Biology;Systems Nutrition;Systems Pharmacology;Stochastic Models;Programming Biology;Multivariate Analysis
Author: Michael Stumpf Publisher: John Wiley & Sons ISBN: 1119952042 Category : Science Languages : en Pages : 624
Book Description
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
Author: Arul Jayaraman Publisher: Artech House ISBN: 1596934069 Category : Science Languages : en Pages : 329
Book Description
"This cutting-edge volume provides a detailed look at the two main aspects of systems biology: the design of sophisticated experimental methods and the development of complex models to analyze the data. Focusing on methods that are being used to solve current problems in biomedical science and engineering, this comprehensive, richly illustrated resource shows you how to: design of state-of-the art methods for analyzing biological systems Implement experimental approaches for investigating cellular behavior in health and disease; use algorithms and modeling techniques for quantitatively describing biomedical problems; and integrate experimental and computational approaches for a more complete view of biological systems." --Book Jacket.
Author: Stephen A. Billings Publisher: John Wiley & Sons ISBN: 1119943590 Category : Technology & Engineering Languages : en Pages : 611
Book Description
Nonlinear System Identification: NARMAX Methods in the Time, Frequency, and Spatio-Temporal Domains describes a comprehensive framework for the identification and analysis of nonlinear dynamic systems in the time, frequency, and spatio-temporal domains. This book is written with an emphasis on making the algorithms accessible so that they can be applied and used in practice. Includes coverage of: The NARMAX (nonlinear autoregressive moving average with exogenous inputs) model The orthogonal least squares algorithm that allows models to be built term by term where the error reduction ratio reveals the percentage contribution of each model term Statistical and qualitative model validation methods that can be applied to any model class Generalised frequency response functions which provide significant insight into nonlinear behaviours A completely new class of filters that can move, split, spread, and focus energy The response spectrum map and the study of sub harmonic and severely nonlinear systems Algorithms that can track rapid time variation in both linear and nonlinear systems The important class of spatio-temporal systems that evolve over both space and time Many case study examples from modelling space weather, through identification of a model of the visual processing system of fruit flies, to tracking causality in EEG data are all included to demonstrate how easily the methods can be applied in practice and to show the insight that the algorithms reveal even for complex systems NARMAX algorithms provide a fundamentally different approach to nonlinear system identification and signal processing for nonlinear systems. NARMAX methods provide models that are transparent, which can easily be analysed, and which can be used to solve real problems. This book is intended for graduates, postgraduates and researchers in the sciences and engineering, and also for users from other fields who have collected data and who wish to identify models to help to understand the dynamics of their systems.
Author: Karel J. Keesman Publisher: Springer Science & Business Media ISBN: 0857295225 Category : Technology & Engineering Languages : en Pages : 323
Book Description
System Identification shows the student reader how to approach the system identification problem in a systematic fashion. The process is divided into three basic steps: experimental design and data collection; model structure selection and parameter estimation; and model validation, each of which is the subject of one or more parts of the text. Following an introduction on system theory, particularly in relation to model representation and model properties, the book contains four parts covering: • data-based identification – non-parametric methods for use when prior system knowledge is very limited; • time-invariant identification for systems with constant parameters; • time-varying systems identification, primarily with recursive estimation techniques; and • model validation methods. A fifth part, composed of appendices, covers the various aspects of the underlying mathematics needed to begin using the text. The book uses essentially semi-physical or gray-box modeling methods although data-based, transfer-function system descriptions are also introduced. The approach is problem-based rather than rigorously mathematical. The use of finite input–output data is demonstrated for frequency- and time-domain identification in static, dynamic, linear, nonlinear, time-invariant and time-varying systems. Simple examples are used to show readers how to perform and emulate the identification steps involved in various control design methods with more complex illustrations derived from real physical, chemical and biological applications being used to demonstrate the practical applicability of the methods described. End-of-chapter exercises (for which a downloadable instructors’ Solutions Manual is available from fill in URL here) will both help students to assimilate what they have learned and make the book suitable for self-tuition by practitioners looking to brush up on modern techniques. Graduate and final-year undergraduate students will find this text to be a practical and realistic course in system identification that can be used for assessing the processes of a variety of engineering disciplines. System Identification will help academic instructors teaching control-related to give their students a good understanding of identification methods that can be used in the real world without the encumbrance of undue mathematical detail.
Author: Meryl E. Wastney Publisher: Academic Press ISBN: 0080926452 Category : Computers Languages : en Pages : 382
Book Description
Investigating Biological Systems Using Modeling describes how to apply software to analyze and interpret data from biological systems. It is written for students and investigators in lay person's terms, and will be a useful reference book and textbook on mathematical modeling in the design and interpretation of kinetic studies of biological systems. It describes the mathematical techniques of modeling and kinetic theory, and focuses on practical examples of analyzing data. The book also uses examples from the fields of physiology, biochemistry, nutrition, agriculture, pharmacology, and medicine. Contains practical descriptions of how to analyze kinetic data Provides examples of how to develop and use models Describes several software packages including SAAM/CONSAM Includes software with working models
Author: Jan de Gier Publisher: Springer Nature ISBN: 3030624978 Category : Mathematics Languages : en Pages : 803
Book Description
MATRIX is Australia’s international and residential mathematical research institute. It facilitates new collaborations and mathematical advances through intensive residential research programs, each 1-4 weeks in duration. This book is a scientific record of the ten programs held at MATRIX in 2019 and the two programs held in January 2020: · Topology of Manifolds: Interactions Between High and Low Dimensions · Australian-German Workshop on Differential Geometry in the Large · Aperiodic Order meets Number Theory · Ergodic Theory, Diophantine Approximation and Related Topics · Influencing Public Health Policy with Data-informed Mathematical Models of Infectious Diseases · International Workshop on Spatial Statistics · Mathematics of Physiological Rhythms · Conservation Laws, Interfaces and Mixing · Structural Graph Theory Downunder · Tropical Geometry and Mirror Symmetry · Early Career Researchers Workshop on Geometric Analysis and PDEs · Harmonic Analysis and Dispersive PDEs: Problems and Progress The articles are grouped into peer-reviewed contributions and other contributions. The peer-reviewed articles present original results or reviews on a topic related to the MATRIX program; the remaining contributions are predominantly lecture notes or short articles based on talks or activities at MATRIX.
Author: Paola Lecca
Author: Paola Lecca
Author: Paola Lecca
Author: James W. Haefner
Author: Corrado Priami
Author: Michael Stumpf
Author: Arul Jayaraman
Author: Stephen A. Billings
Author: Karel J. Keesman
Author: Meryl E. Wastney
Author: Jan de Gier