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Author: D. Neil Granger Publisher: Morgan & Claypool Publishers ISBN: 1615041656 Category : Medical Languages : en Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author: D. Neil Granger Publisher: Morgan & Claypool Publishers ISBN: 1615041656 Category : Medical Languages : en Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author: Benjamin W. Zweifach Publisher: Academic Press ISBN: 1483261700 Category : Nature Languages : en Pages : 948
Book Description
The Inflammatory Process focuses on the approaches, methodologies, and technologies involved in the study of the inflammatory process, including capillary structure, tissue injury, and inflammatory response. The selection first offers information on the experimental approach to inflammation, ultrastructural and biochemical consequences of cell injury, and ultrastructural basis of capillary permeability. Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation. The text then elaborates on the microvascular aspects of tissue injury and the sticking and emigration of white blood cells in inflammation. The book examines neutrophil and eosinophil leucocytes, "life history" and functions of lymphocytes, and metabolism and physiology of mononuclear phagocytes. Topics include inflammatory response, biochemistry and metabolism, special relationships to bacteria and viruses, and origins and early development of lymphocytes. The text also ponders on the role of lysosomes in tissue injury, hemostatic mechanisms in tissue injury, and anti-inflammatory agents. The selection is a vital source of data for researchers interested in the inflammatory process.
Author: Adriano Rossi Publisher: Springer Science & Business Media ISBN: 376437506X Category : Medical Languages : en Pages : 240
Book Description
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Author: Charles N. Serhan Publisher: Cambridge University Press ISBN: 0521887291 Category : Medical Languages : en Pages : 489
Book Description
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.
Author: National Research Council Publisher: National Academies Press ISBN: 9780309039925 Category : Science Languages : en Pages : 198
Book Description
Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.
Author: Forrest "Dell" Moore Publisher: John Wiley & Sons ISBN: 1119317959 Category : Medical Languages : en Pages : 544
Book Description
A unique question-and-answer book for surgical residents and trainees that covers all surgical aspects of critical care and acute or emergency medicine This is a comprehensive, one-of-a-kind question-and-answer text for medical professionals and apprentices concentrating on the growing subspecialty of surgery in critical care and emergency surgery. Covering all surgical aspects of critical care and acute or emergency surgery, it is an ideal learning and review text for surgical residents and trainees who care for these patients and those taking the Surgical Critical Care Board Examination. Edited by highly experienced professionals, and written in an engaging style, Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers focuses exclusively on the unique problems and complexity of illnesses of the critically ill and injured surgical patient, and covers the specialist daily care such patients require. It reflects the latest advances in medical knowledge and technology, and includes fully revised and updated questions throughout, with additional topics addressed in a new companion website. Unique question-and-answer book on the growing specialty of critical care and acute surgery Ideal for US boards candidates Covers trauma and burns as well as critical care 8 page full-color insert showing high quality surgical photos to aid study Supplementary website including additional questions Surgical Critical Care and Emergency Surgery, Second Edition is an excellent resource for medical students, residents, fellows, and surgeons, as well as those in non-surgical specialties.
Author: Kenneth Murphy Publisher: Garland Science ISBN: 9780815344575 Category : Medical Languages : en Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: D. Neil Granger
Author: D. Neil Granger
Author: Benjamin W. Zweifach
Author: Maurício Rocha e Silva
Author: Adriano Rossi
Author: H. Z. Movat
Author: Charles N. Serhan
Author: Bruce Alberts
Author: National Research Council
Author: Forrest "Dell" Moore
Author: Kenneth Murphy