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Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models

Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models PDF Author: Mary M. Torregrossa
Publisher: Frontiers Media SA
ISBN: 2889455300
Category :
Languages : en
Pages : 201

Book Description
The purpose of this collection is to provide a forum to integrate pre-clinical and clinical investigations regarding the long-term consequences of adolescent exposure to drugs of abuse. Adolescence is characterized by numerous behavioral and biological changes, including substantial neurodevelopment. Behaviorally, adolescents are more likely to engage in risky activities and make impulsive decisions. As such, the majority of substance use begins in adolescence, and an earlier age of onset of use (<15 yr) is strongly associated with the risk for developing a substance use disorder later in life. Furthermore, adolescent drug use may negatively impact ongoing neurological development, which could lead to long-term cognitive and emotional deficits. A large number of clinical studies have investigated both the acute and long-term effects of adolescent drug use on functional outcomes. However, the clinical literature contains many conflicting findings, and is often hampered by the inability to know if functional differences existed prior to drug use. Moreover, in human populations it is often very difficult to control for the numerous types of drugs, doses, and combinations used, not to mention the many other environmental factors that may influence adult behavior. Therefore, an increase in the number of carefully controlled studies using relevant animal models has the potential to clarify which adolescent experiences, particularly what drugs used when, have long-term negative consequences. Despite the advantages of animal model systems in clarifying these issues, the majority of pre-clinical addiction research over the past 50+ years has been conducted in adult animals. Moreover, few addiction-related studies have investigated the long-term neurocognitive consequences of drug exposure at any age. In the past 10 years of so, however, the field of adolescent drug abuse research has burgeoned. To date, the majority of this research has focused on adolescent alcohol exposure using a variety of animal models. The results have given the field important insight into why adolescents are more likely to drink alcohol to excess relative to adults, and the danger of adolescent alcohol use (e.g., in leading to a persistence of excessive drinking in adulthood). More recently, research regarding the effects of adolescent exposure to other drugs of abuse, including nicotine, cocaine, and cannabinoids has expanded. Therefore, we are at unique point in time, when emerging results from carefully controlled pre-clinical studies can inform the sometimes confusing clinical literature. In addition, we expect an influx of prospective clinical studies in response to a cross-institute initiative at NIH, known as the ABCD grant. Several institutes are enrolling children prior to adolescence (and the initiation of drug use), in order to control for pre-existing neurobiological and neurobehavioral differences and to monitor the age of initiation and amount of drug used more carefully than is possible using retrospective designs.

Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models

Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models PDF Author: Mary M. Torregrossa
Publisher: Frontiers Media SA
ISBN: 2889455300
Category :
Languages : en
Pages : 201

Book Description
The purpose of this collection is to provide a forum to integrate pre-clinical and clinical investigations regarding the long-term consequences of adolescent exposure to drugs of abuse. Adolescence is characterized by numerous behavioral and biological changes, including substantial neurodevelopment. Behaviorally, adolescents are more likely to engage in risky activities and make impulsive decisions. As such, the majority of substance use begins in adolescence, and an earlier age of onset of use (<15 yr) is strongly associated with the risk for developing a substance use disorder later in life. Furthermore, adolescent drug use may negatively impact ongoing neurological development, which could lead to long-term cognitive and emotional deficits. A large number of clinical studies have investigated both the acute and long-term effects of adolescent drug use on functional outcomes. However, the clinical literature contains many conflicting findings, and is often hampered by the inability to know if functional differences existed prior to drug use. Moreover, in human populations it is often very difficult to control for the numerous types of drugs, doses, and combinations used, not to mention the many other environmental factors that may influence adult behavior. Therefore, an increase in the number of carefully controlled studies using relevant animal models has the potential to clarify which adolescent experiences, particularly what drugs used when, have long-term negative consequences. Despite the advantages of animal model systems in clarifying these issues, the majority of pre-clinical addiction research over the past 50+ years has been conducted in adult animals. Moreover, few addiction-related studies have investigated the long-term neurocognitive consequences of drug exposure at any age. In the past 10 years of so, however, the field of adolescent drug abuse research has burgeoned. To date, the majority of this research has focused on adolescent alcohol exposure using a variety of animal models. The results have given the field important insight into why adolescents are more likely to drink alcohol to excess relative to adults, and the danger of adolescent alcohol use (e.g., in leading to a persistence of excessive drinking in adulthood). More recently, research regarding the effects of adolescent exposure to other drugs of abuse, including nicotine, cocaine, and cannabinoids has expanded. Therefore, we are at unique point in time, when emerging results from carefully controlled pre-clinical studies can inform the sometimes confusing clinical literature. In addition, we expect an influx of prospective clinical studies in response to a cross-institute initiative at NIH, known as the ABCD grant. Several institutes are enrolling children prior to adolescence (and the initiation of drug use), in order to control for pre-existing neurobiological and neurobehavioral differences and to monitor the age of initiation and amount of drug used more carefully than is possible using retrospective designs.

Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models

Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

Book Description
The purpose of this collection is to provide a forum to integrate pre-clinical and clinical investigations regarding the long-term consequences of adolescent exposure to drugs of abuse. Adolescence is characterized by numerous behavioral and biological changes, including substantial neurodevelopment. Behaviorally, adolescents are more likely to engage in risky activities and make impulsive decisions. As such, the majority of substance use begins in adolescence, and an earlier age of onset of use (

Adolescent Brain Development

Adolescent Brain Development PDF Author: Ronald E. Dahl
Publisher:
ISBN:
Category : Adolescent psychology
Languages : en
Pages : 496

Book Description
The papers in these proceedings of the September 2003 conference examine this key period in life and its associated behavioral and emotional problems. General paper topics include risk taking and novelty seeking, brain and cognitive development, the interrelationships between hormones and behavior, nicotine and alcohol use, sleep and arousal, and the regulation of behavior and emotion. The volume includes short papers on human and animal studies. Papers include their own references. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com).

The Oxford Handbook of Adolescent Substance Abuse

The Oxford Handbook of Adolescent Substance Abuse PDF Author: Robert A. Zucker
Publisher: Oxford University Press, USA
ISBN: 0199735662
Category : Psychology
Languages : en
Pages : 857

Book Description
Adolescent substance abuse is the nation's #1 public health problem. It originates out of a developmental era where experimentation with the world is increasingly taking place, and where major changes in physical self and social relationships are taking place. These changes cannot be understood by any one discipline nor can they be described by focusing only on the behavioral and social problems of this age period, the characteristics of normal development, or the pharmacology and addictive potential of specific drugs. They require knowledge of the brain's systems of reward and control, genetics, psychopharmacology, personality, child development, psychopathology, family dynamics, peer group relationships, culture, social policy, and more. Drawing on the expertise of the leading researchers in this field, this Handbook provides the most comprehensive summarization of current knowledge about adolescent substance abuse. The Handbook is organized into eight sections covering the literature on the developmental context of this life period, the epidemiology of adolescent use and abuse, similarities and differences in use, addictive potential, and consequences of use for different drugs; etiology and course as characterized at different levels of mechanistic analysis ranging from the genetic and neural to the behavioural and social. Two sections cover the clinical ramifications of abuse, and prevention and intervention strategies to most effectively deal with these problems. The Handbook's last section addresses the role of social policy in framing the problem, in addressing it, and explores its potential role in alleviating it.

Substance Misuse Prevention for Young Adults (Evidence-based Resource Guide Series)

Substance Misuse Prevention for Young Adults (Evidence-based Resource Guide Series) PDF Author: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Publisher:
ISBN: 9781678198107
Category : Reference
Languages : en
Pages : 0

Book Description
For those who show heavier patterns of drinking, frequent binge drinking, regular nicotine intake, or early onset of substance use, interventions are required to prevent serious consequences of problem use and alter the path toward substance use disorder (SUD).2 Such interventions include practices shown to delay substance use initiation in adolescents and reduce substance misuse and its associated consequences in young adulthood. Effective prevention practices address factors that place young adults at increased risk for substance misuse-or protect them from substance misuse-and often focus on youth who may be more vulnerable due to their life circumstances, sexual orientation, and preexisting health conditions.

Handbook of Developmental Psychopathology

Handbook of Developmental Psychopathology PDF Author: Michael Lewis
Publisher: Springer
ISBN: 9781489976727
Category : Psychology
Languages : en
Pages : 0

Book Description
When developmental psychologists set forth the theory that the roots of adult psychopathology could be traced to childhood experience and behavior, the idea quickly took hold. Subsequently, as significant research in this area advanced during the past decade, more sophisticated theory, more accurate research methodologies, and improved replication of empirical findings have been the result. The Third Edition of the Handbook of Developmental Psychopathology incorporates these research advances throughout its comprehensive, up-to-date examination of this diverse and maturing field. Integrative state-of-the-art models document the complex interplay of risk and protective factors and other variables contributing to normal and pathological development. New and updated chapters describe current refinements in assessment methods and offer the latest research findings from neuroscience. In addition, the Third Edition provides readers with a detailed review across the spectrum of salient topics, from the effects of early deprivation to the impact of puberty. As the field continues to shift from traditional symptom-based concepts of pathology to a contemporary, dynamic paradigm, the Third Edition addresses such key topics as: Early Childhood disorders, including failure to thrive and attachment disorders. Aggression, ADHD, and other disruptive conditions. Developmental models of depression, anxiety, self-injury/suicide, and OCD. The autism spectrum and other chronic developmental disorders. Child maltreatment and trauma disorders. The Third Edition of the Handbook of Developmental Psychopathology is a discipline-defining, forward-looking resource for researchers, clinicians, scientist-practitioners, and graduate students in such fields as developmental psychology, psychiatry, social work, child and school psychology, educational psychology, and pediatrics.“p>

Theories on Drug Abuse

Theories on Drug Abuse PDF Author: National Institute on Drug Abuse. Division of Research
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 534

Book Description


Adolescent Substance Abuse

Adolescent Substance Abuse PDF Author: Carl G. Leukefeld
Publisher: Springer
ISBN: 3319906119
Category : Psychology
Languages : en
Pages : 397

Book Description
The second edition of this book incorporates the latest theory, research, and best practices for understanding, treating, and preventing substance abuse among adolescents. It updates the progress made in treatments for and prevention of the misuse of substances and adds new specific chapters on prescriptions, opiates, and methamphetamine abuse. The book discusses the effects of commonly abused substances, from tobacco and alcohol to stimulants and opioids, on the human brain and the various psychosocial routes to their misuse by adolescents. Chapters provide evidence-based guidelines for assessing adolescent treatment needs and review psychological, pharmacological, family, and self-help interventions. The book offers new paths in diverse directions, analyzes the core components of substance use prevention, critiques emerging school-based interventions, and introduces a nuanced reconceptualization of recovery. Topics featured in the book include: The effect of family and caregiver situations on adolescent substance abuse. A biological/genetic perspective on adolescent substance abuse. School-based preventions and the evolution of evidence-based strategies. The role of adolescent self-help in substance abuse interventions. Community-based interventions to reduce alcohol use and misuse. Adolescent Substance Abuse, Second Edition, is a must-have reference for researchers, clinicians/practitioners, and graduate students in the fields of child and school psychology, social work, public health, developmental psychology, child and adolescent psychiatry, and various interrelated mental health and social policy arenas.

Adolescent Substance Abuse

Adolescent Substance Abuse PDF Author: Howard A. Liddle
Publisher: Cambridge University Press
ISBN: 1139449907
Category : Medical
Languages : en
Pages : 489

Book Description
This book was first published in 2006. Adolescent drug abuse is one of the most challenging disorders to treat. It impacts on schools, community-based programs, mental health and medical facilities, and juvenile justice settings. This book provides practitioners, program developers and policy makers with practical information for improving outcomes in adolescent substance abuse. The authors cover a range of issues, including empirically based treatment development protocols, how to incorporate innovative treatment models into diverse clinical settings; research advances; interventions with special populations, culturally based intervention guidelines, and recommendations for practice and policy.

Drugs, Brains, and Behavior

Drugs, Brains, and Behavior PDF Author:
Publisher:
ISBN:
Category : Brain
Languages : en
Pages : 76

Book Description