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Author: Bradley Layton Publisher: CRC Press ISBN: 9814613444 Category : Medical Languages : en Pages : 232
Book Description
This book bridges the gap between life sciences and physical sciences by providing several perspectives on cellular and molecular mechanics on a fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics and then moves from the molecular scale to the tissue scale. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics. "Big picture" items, such as the number of atoms in cells and the number of cells in an organism, are discussed, followed by several of the physical laws that play a central role in nanoscale biomechanics, including the mechanics of the nucleus and its associated molecules. The book provides several case studies in atomic force microscopy and examines the physical relationship between living cells and laboratory substrata. It delves deeply into the molecular mechanisms of axonal growth, transport, and repair and provides a mechanistic framework for understanding the underlying molecular conditions that contribute to heart disease. While the quantitative and straightforward language of the book will help the engineering community grasp the concepts better and utilize them effectively, the questions given in each chapter will encourage upper-level undergraduate students, graduate students, or those generally interested in understanding cellular and molecular mechanics to dig deeper into the material. The complimentary solutions manual is available for qualified instructors upon request.
Author: Bradley Layton Publisher: CRC Press ISBN: 9814613444 Category : Medical Languages : en Pages : 232
Book Description
This book bridges the gap between life sciences and physical sciences by providing several perspectives on cellular and molecular mechanics on a fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics and then moves from the molecular scale to the tissue scale. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics. "Big picture" items, such as the number of atoms in cells and the number of cells in an organism, are discussed, followed by several of the physical laws that play a central role in nanoscale biomechanics, including the mechanics of the nucleus and its associated molecules. The book provides several case studies in atomic force microscopy and examines the physical relationship between living cells and laboratory substrata. It delves deeply into the molecular mechanisms of axonal growth, transport, and repair and provides a mechanistic framework for understanding the underlying molecular conditions that contribute to heart disease. While the quantitative and straightforward language of the book will help the engineering community grasp the concepts better and utilize them effectively, the questions given in each chapter will encourage upper-level undergraduate students, graduate students, or those generally interested in understanding cellular and molecular mechanics to dig deeper into the material. The complimentary solutions manual is available for qualified instructors upon request.
Author: K. Dane Wittrup Publisher: MIT Press ISBN: 0262042657 Category : Science Languages : en Pages : 593
Book Description
A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
Author: C. Ross Ethier Publisher: Cambridge University Press ISBN: 1139461826 Category : Technology & Engineering Languages : en Pages : 10
Book Description
Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.
Author: Atsushi Ikai Publisher: Elsevier ISBN: 9780444636867 Category : Science Languages : en Pages : 412
Book Description
"The World of Nano-Biomechanics, Second Edition, "focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, sub-cellular organelles, and live cells are discussed. New to this second edition are recent developments in two important applications, i.e., high-resolution mechanical biosensors and the use of cell mechanics for medical diagnosis. Fully revised and expanded new edition based on the latest research and developments in the fieldExplains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work Presents recent developments of force-based biosensorsIncludes novel applications of nano-biomechanics to the medical field
Author: Krishna Garikipati Publisher: Springer Science & Business Media ISBN: 9048133483 Category : Technology & Engineering Languages : en Pages : 273
Book Description
The invited papers in this book reflect the current understanding of the role mechanics play in the biological system at the molecular, cellular and tissue levels. Topics range from tissue engineering and mechanics to mechanics of cells and biomolecules.
Author: Paola Lecca Publisher: Springer Science & Business Media ISBN: 9400758901 Category : Technology & Engineering Languages : en Pages : 168
Book Description
The application of methodological approaches and mathematical formalisms proper to Physics and Engineering to investigate and describe biological processes and design biological structures has led to the development of many disciplines in the context of computational biology and biotechnology. The best known applicative domain is tissue engineering and its branches. Recent domains of interest are in the field of biophysics, e.g.: multiscale mechanics of biological membranes and films and filaments; multiscale mechanics of adhesion; biomolecular motors and force generation. Modern hypotheses, models, and tools are currently emerging and resulting from the convergence of the methods and phylosophycal apporaches of the different research areas and disciplines. All these emerging approaches share the purpose of disentangling the complexity of organisms, tissues, and cells and mimiking the function of living systems. The contributions presented in this book are current research highlights of six challenging and representative applicative domains of phyisical, engineering, and computational approaches in medicine and biology, i.e tissue engineering, modelling of molecular structures, cell mechanics and cell adhesión processes, cancer physics, and physico-chemical processes of metabolic interactions. Each chapter presents a compendium or a review of the original results achieved by authors in the last years. Furthermore, the book also wants to pinpoint the questions that are still open and that could propel the future research.
Author: Shu Chien Publisher: ISBN: 9781734020601 Category : Languages : en Pages :
Book Description
Professor Fung has rightfully earned a place in history, as the father of modern biomechanics. It is our great fortune to be associated with him. It is also a great fortune for the Journal, MCB: Molecular & Cellular Biomechanics to have Professor Fung as its Honorary Editor. We are heartened that many of the world-leaders in science and engineering have contributed to this volume, and to MCB, to pay their tributes to Professor Fung on his 100th birthday.
Author: Krishna Garikipati Publisher: ISBN: 9789048133680 Category : Biomechanics Languages : en Pages :
Book Description
These are the proceedings of an IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, held in the summer of 2008 at Woods Hole, Mass, USA. This groundbreaking meeting brought together mechanicians having an interest in biological systems, with biophysicists and biologists in order to address the mechanical basis of biology at the molecular, cellular and tissue scales. The meeting explored a wealth of phenomena in cell and molecular biology all of which display a breadth of mechanical influences that may seem surprising at first glance to the traditional mechanician. This arena for the application of methods developed in mechanics has not drawn as much attention as more traditional tissue biomechanics. However, biophysicists, and even biologists apply ideas of elasticity and structural mechanics quite widely in studying molecules and cells. Many critical functions of biomolecules and cells are fundamentally mechanical in origin, and the mechanics of many biomolecules demonstrate scaling laws that are non-classical to traditional structural mechanics and elasticity. This compilation of the scientific papers presented at the meeting will prove invaluable to researchers in the mechanics of biology as this field develops in the decades to come and takes its place as an acknowledged and central area in biology.
Author: David H. Boal Publisher: Cambridge University Press ISBN: 0521113768 Category : Science Languages : en Pages : 623
Book Description
New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.
Author: Mohammad R. K. Mofrad Publisher: Cambridge University Press ISBN: 1139458108 Category : Science Languages : en Pages : 231
Book Description
This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.
Author: Bradley Layton
Author: Bradley Layton
Author: K. Dane Wittrup
Author: C. Ross Ethier
Author: Atsushi Ikai
Author: Krishna Garikipati
Author: Paola Lecca
Author: Shu Chien
Author: Krishna Garikipati
Author: David H. Boal
Author: Mohammad R. K. Mofrad