Oral & Intravenous Bisphosphonate-induced Osteonecrosis of the Jaws PDF Download

Author: Robert E. Marx
Publisher: Quintessence Publishing (IL)
ISBN:
Category : Medical
Languages : en
Pages : 172

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Book Description
Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws deals with dentistry.

Author: Robert E. Marx
Publisher:
ISBN: 9780867159011
Category :
Languages : en
Pages : 164

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Book Description

Author: Francesco Saverio De Ponte
Publisher: Springer Science & Business Media
ISBN: 9788847020832
Category : Medical
Languages : en
Pages : 181

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Book Description
During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.

Author: Sven Otto
Publisher: Springer
ISBN: 3662437333
Category : Medical
Languages : en
Pages : 220

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Book Description
Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.

Author: Salvatore L. Ruggiero
Publisher: Elsevier Health Sciences
ISBN: 0323413471
Category : Medical
Languages : en
Pages :

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Book Description
Editor Salvatore Ruggiero, DMD, MD and authors review the Diagnosis, Management and Prevention of Medication-related Osteonecrosis of the Jaw. Articles will include: Osteoporosis and bone modulation therapies: indications and outcomes; Antiresorptive therapies for the treatment of malignant osteolytic bone disease; Clinical presentation and staging of antiresorptive agent-induced osteonecrosis of the jaw; Epidemiology and risk factors of antiresorptive agent-induced osteonecrosis of the jaw; Basic science research of antiresorptive agent-induced osteonecrosis of the jaw: an update; Pathophysiology of antiresorptive agent-induced osteonecrosis of the jaw: what we know and what we don’t know; The genetics of osteonecrosis of the jaw; Preventive strategies for patients at risk of antiresorptive agent-induced osteonecrosis of the jaw; Non-operative and operative therapies for treatment of antiresorptive agent-induced osteonecrosis of the jaw; The role of anti-angiogenic therapy in the development of osteonecrosis of the jaw; Antiresorptive therapies: what they are and how do they work, and more!

Author: Kenneth Fleisher
Publisher: Thieme
ISBN: 313258228X
Category : Medical
Languages : en
Pages : 125

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Book Description
A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.

Author: Mazen Ahmad Almasri
Publisher: BoD – Books on Demand
ISBN: 1789854113
Category : Medical
Languages : en
Pages : 180

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Book Description
The aim of the book “Maxillofacial Surgery and Craniofacial Deformity - Practices and Updates” was to collect various aspects of facial and cranial deformities in one single textbook in order to have a systematic way of thinking when approaching these interconnected manifestations. Furthermore, other associated social aspects of health care are integrated to give a wider view of the problem and some important considerations of care.

Author: Marc Baltensperger
Publisher: Springer Science & Business Media
ISBN: 3540287663
Category : Medical
Languages : en
Pages : 320

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Book Description
“Osteomyelitis of the Jaws” is the first textbook of its kind covering exclusively all aspects of this challenging disease. A clear classification of osteomyelitis of the jaws is provided. Clinical presentation and diagnosis are meticulously described and illustrated. Radiological imaging from conventional radiographs to CT, MRI and PET diagnosis are outlined for all types of osteomyelitis of the jaws. Pathology and Pathophysiology of this disease are described in a clear way. All therapeutic modalities from surgery to antibiotic and hyperbaric oxygen therapy are comprehensively outlined and discussed. Each type of Osteomyelitis of the jaws are additionally described and illustrated in case reports giving this book a very practical approach to the subject.

Author: Shahrokh C. Bagheri
Publisher: Elsevier Health Sciences
ISBN: 1455727571
Category : Medical
Languages : en
Pages : 1133

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Book Description
Written by expert surgeons and educators, Current Therapy in Oral and Maxillofacial Surgery covers the latest treatment strategies, surgical techniques, and potential complications in OMS. Emphasizing an evidence-based approach, it covers all 12 subspecialties of OMS, addressing topics from surgical principles to oral surgery, anesthesia, cranio-maxillofacial trauma surgery, head and neck surgery, maxillofacial reconstructive surgery, orthognathic surgery, pediatric craniofacial surgery including cleft lip and palate, temporomandibular joint disorders, facial plastic surgery including rhinoplasty and facelifts, obstructive sleep apnea, and oral and maxillofacial infections. At the end of each chapter, Pearls and Pitfalls summarize the authors' insight, recommendations, and experience on that topic. Editor Dr. Shahrokh Bagheri is a noted professor, researcher, and speaker on OMS, and he leads an expert author team including Dr. R. Bryan Bell and Dr. Husain Ali Khan to help you master and apply the latest advances in OMS. More than 1,200 full-color photos and 200 color line drawings illustrate concepts and provide visual guidance in clinical areas. Comprehensive sections and chapters represent essential topics, the newest advances, and controversial topics. Clinical coverage brings together the latest knowledge in OMS in a concise, easy-to-apply way. Resident-specific coverage describes the wide array of subspecialties and treatments available in the armamentarium of the modern OMS. A focus on complications ensures that you are knowledgeable in this important part of any therapy or surgical discipline. Expert contributors include the "best of the best," featuring leading, well-established, and respected surgeons and educators writing on their areas of specialty and providing current treatment strategies.

Author: Friedhelm Raue
Publisher: Springer Science & Business Media
ISBN: 3642850731
Category : Medical
Languages : en
Pages : 211

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Book Description
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.