Phosphodiesterases: CNS Functions and Diseases PDF Download

Author: Han-Ting Zhang
Publisher: Springer
ISBN: 3319588117
Category : Medical
Languages : en
Pages : 471

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Book Description
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Author: Nicholas J. Brandon
Publisher: John Wiley & Sons
ISBN: 1118836308
Category : Medical
Languages : en
Pages : 400

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Book Description
This book reviews advances in understanding phosphodiesteraseswithin the central nervous system and their therapeuticapplications. A range of expert authors from both academia andindustry describe these, then focus on the areas of greatestscientific and medical interest to provide more detailed coverage.Therapeutic and drug discovery applications are covered fordiseases including Alzheimer's, Parkinson's, schizophrenia,erectile dysfunction, and spinal cord injuries. There is also achapter on drug discovery tools such as in vitro assays and X-raystructures for medicinal chemistry studies.

Author:
Publisher:
ISBN: 9783319588100
Category : Nervous system
Languages : en
Pages :

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Book Description
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Author: XiaoDong Cheng
Publisher: CRC Press
ISBN: 9780367658809
Category : Cellular signal transduction
Languages : en
Pages : 288

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Book Description
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

Author: Roberto Erro
Publisher: Cambridge University Press
ISBN: 1107472423
Category : Medical
Languages : en
Pages : 183

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Book Description
A thorough collection of movement disorders cases, each discussed by international experts and accompanied by illustrative video content.

Author: Mark Edwards
Publisher: Oxford University Press, USA
ISBN: 019856984X
Category : Medical
Languages : en
Pages : 336

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Book Description
A reference on the management of Parkinson's disease and other movement disorders, this book offers practical advice on the classification and diagnosis of patients, and available treatment options.

Author: Gonzalo Emiliano Aranda Abreu
Publisher: BoD – Books on Demand
ISBN: 9535134515
Category : Medical
Languages : en
Pages : 320

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Book Description
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Author: Joseph A. Beavo
Publisher: CRC Press
ISBN: 1420020846
Category : Medical
Languages : en
Pages : 728

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Book Description
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

Author: G. Michael Felker
Publisher: Elsevier Health Sciences
ISBN: 0323609880
Category : Medical
Languages : en
Pages : 784

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Book Description
Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Author: Ivan Donaldson
Publisher: Oxford University Press
ISBN: 0191502243
Category : Medical
Languages : en
Pages : 1512

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Book Description
This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.