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Author: Christophe Chipot Publisher: Springer Science & Business Media ISBN: 3540384472 Category : Language Arts & Disciplines Languages : en Pages : 528
Book Description
Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.
Author: Christophe Chipot Publisher: Springer Science & Business Media ISBN: 3540384472 Category : Language Arts & Disciplines Languages : en Pages : 528
Book Description
Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.
Author: C.Reyes Mateo Publisher: Springer Science & Business Media ISBN: 9783540852827 Category : Science Languages : en Pages : 260
Book Description
Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.
Author: Pier Luigi Luisi Publisher: John Wiley & Sons ISBN: 0470511524 Category : Science Languages : en Pages : 426
Book Description
Perspectives in Supramolecular Chemistry Founded by J.-M. Lehn Perspectives in Supramolecular Chemistry reflects research which develops supramolecular structures with specific new properties, such as recognition, transport and simulation of biosystems or new materials. The series covers all areas from theoretical and modelling aspects through organic and inorganic chemistry and biochemistry to materials, solid-state and polymer sciences reflecting the many and varied applications of supramolecular structures in modern chemistry. Giant Vesicles Edited by Pier Luigi Luisi and Peter Walde Institute für Polymere, ETH-Zürich, Switzerland Giant vesicles or giant liposomes are supramolecular assembles of amphiphiles, surface active substances which normally contain one or two hydrophobic chains and one hydrophilic head. Due to their relatively large size, giant vesicles are easily observed by light microscopy. This volume provides an overview of ideas and results obtained from experimental studies as well as theoretical approaches. A wide variety of aspects ranging from pure mathematics and physical considerations to biochemical and biological applications are covered. Historical and fundamental aspects are discussed as well as a range of experimental approaches including the micromanipulation and micro-puncturing of single giant vesicles. 87 international contributors comment on a wide range of issues contained under the five main part headings: Introduction Preparation Methods Basic Theoretical Aspects Physical Properties Chemical and Biological Aspects. Giant Vesicles has been written for researchers in the fields of chemistry, biochemistry and biophysics, working in supra-molecular chemistry, surfactant science, liposome and pharmaceutical sciences.
Author: A.N. Martonosi Publisher: Springer Science & Business Media ISBN: 1468445987 Category : Science Languages : en Pages : 467
Book Description
In the first edition of The Enzymes of Biological Membranes, published in four volumes in 1976, we collected the mass of widely scattered information on membrane-linked enzymes and metabolic processes up to about 1975. This was a period of transition from the romantic phase of membrane biochemistry, preoccupied with conceptual developments and the general properties of membranes, to an era of mounting interest in the specific properties of membrane-linked enzymes analyzed from the viewpoints of modem enzymology. The level of sophistication in various areas of membrane research varied widely; the structures of cytochrome c and cytochrome b5 were known to atomic detail, while the majority of membrane-linked enzymes had not even been isolated. In the intervening eight years our knowledge of membrane-linked enzymes ex panded beyond the wildest expectations. The purpose of the second edition of The Enzymes of Biological Membranes is to record these developments. The first volume describes the physical and chemical techniques used in the analysis of the structure and dynamics of biological membranes. In the second volume the enzymes and met abolic systems that participate in the biosynthesis of cell and membrane components are discussed. The third and fourth volumes review recent developments in active transport, oxidative phosphorylation and photosynthesis.
Author: Anthony Watts Publisher: Elsevier ISBN: 9780080860855 Category : Science Languages : en Pages : 378
Book Description
Protein-lipid interactions as a field of study is now a mature area, and this volume of New Comprehensive Biochemistry has been published with two objectives in mind. Firstly, to look to the future, and try to envisage how the subject may develop in the near to medium future. Secondly, to present contrasting or complementary views on the same system. For example, the acetylcholine receptor is discussed from a predominantly structural aspect by Barrantes, and from the kinetic standpoint by Rankin, et al. The volume not only gives an update on specific aspects of the field, but also shows the way in which the phenomenon of protein-lipid interactions is now seemingly infiltrating many areas of biomembrane research, from recombinant DNA studies, protein insertion and assembly and reconstitution considerations to structural studies of membrane proteins.
Author: Jorg H. Kleinschmidt Publisher: Humana Press ISBN: 9781493962631 Category : Science Languages : en Pages : 476
Book Description
This book provides a selection of protocols to examine protein-lipid interactions, membrane and membrane protein structure, how membrane proteins affect lipids and how they are in turn affected by the lipid bilayer and lipid properties.
Author: Jordi H. Borrell Publisher: Springer ISBN: 3319302779 Category : Science Languages : en Pages : 116
Book Description
This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions. A general introduction is presented in Chapters 1 and 2. The following Chapters, 3 and 4, describe the most accepted theories on lipid-membrane protein interactions as well as the new experimental approaches, in particular, these arose from nano sciences as atomic for microscopy and single molecule force spectroscopy. The book emphasizes the relevance of physical parameters as the lateral surface pressure and the lipid curvature as actors for understanding the physicochemical properties of the biomembranes.
Author: Lukas K. Tamm Publisher: John Wiley & Sons ISBN: 3527606998 Category : Science Languages : en Pages : 470
Book Description
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
Author: Sidney A. Simon Publisher: Academic Press ISBN: 0080925855 Category : Science Languages : en Pages : 606
Book Description
This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction
Author: Christophe Chipot
Author: Christophe Chipot
Author: C.Reyes Mateo
Author: Bruce Alberts
Author: Pier Luigi Luisi
Author: A.N. Martonosi
Author: Anthony Watts
Author: Jorg H. Kleinschmidt
Author: Jordi H. Borrell
Author: Lukas K. Tamm
Author: Sidney A. Simon