The Dependent Gene PDF Download

Author: David S. Moore
Publisher: Macmillan
ISBN: 9780805072808
Category : Science
Languages : en
Pages : 324

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Book Description
This book provides an analysis of the nature vs. nuture debate, arguing for an end to the 'either/or' nature of the discussions in favor of a recognition that environmental and genetic factors interact throughout life to form human traits.

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1476733538
Category : Medical
Languages : en
Pages : 624

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Book Description
The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Author: David Latchman
Publisher: Garland Science
ISBN: 1136844201
Category : Science
Languages : en
Pages : 960

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Book Description
Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchman’s Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control. Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309069882
Category : Social Science
Languages : en
Pages : 610

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Book Description
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author: Stanley Fields
Publisher: MIT Press
ISBN: 0262518643
Category : Science
Languages : en
Pages : 236

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Book Description
How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.

Author: Susumu Ohno
Publisher: Springer Science & Business Media
ISBN: 364286659X
Category : Medical
Languages : en
Pages : 171

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Book Description
It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309120926
Category : Science
Languages : en
Pages : 90

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Book Description
Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

Author: Barbara Landau
Publisher: Oxford University Press
ISBN: 0199921377
Category : Psychology
Languages : en
Pages :

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Book Description
Our experience of the spatial world is a unitary one; we perceive objects and layouts, we remember them and act on them, and we can even talk about them with ease. Despite this impression of seamlessness, spatial representations in human adults appear to be specialized in domain-dependent manner, engaging different properties and computational mechanisms for different functions. In this book, the authors present evidence that this domain-specific specialization in cognitive function emerges early in development and is reflected in patterns of breakdown that occur under genetic defect. The authors focus on spatial representation in children and adults with Williams syndrome, a relatively rare genetic syndrome that gives rise to an unusual profile of severely impaired spatial representation together with spared language. Results from a variety of spatial domains -- including object representation, motion perception, action, navigation, and spatial language -- appear to display a strikingly uneven profile of sparing and deficit within spatial representations, consistent with the idea that specialization of function drives development and breakdown. These findings raise a crucial question: Can specific genes target specific aspects of cognitive structure? Looking deeper into the patterns of performance across spatial domains, the book explores the notion that understanding patterns of normal development across domains is crucial to understanding unusual development. Using insights from normal development, the authors propose a speculative hypothesis that explains the emergence of the William syndrome profile, and how complex cognitive outcomes can arise from the deletion of a small set of genes.

Author: Richard Dawkins
Publisher: Oxford University Press, USA
ISBN: 9780192860927
Category : Medical
Languages : en
Pages : 372

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Book Description
Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

Author: James Tabery
Publisher: MIT Press
ISBN: 0262549603
Category : Science
Languages : en
Pages : 295

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Book Description
Why the “nature versus nurture” debate persists despite widespread recognition that human traits arise from the interaction of nature and nurture. If everyone now agrees that human traits arise not from nature or nurture but from the interaction of nature and nurture, why does the “nature versus nurture” debate persist? In Beyond Versus, James Tabery argues that the persistence stems from a century-long struggle to understand the interaction of nature and nurture—a struggle to define what the interaction of nature and nurture is, how it should be investigated, and what counts as evidence for it. Tabery examines past episodes in the nature versus nurture debates, offers a contemporary philosophical perspective on them, and considers the future of research on the interaction of nature and nurture. From the eugenics controversy of the 1930s and the race and IQ controversy of the 1970s to the twenty-first-century debate over the causes of depression, Tabery argues, the polarization in these discussions can be attributed to what he calls an “explanatory divide”—a disagreement over how explanation works in science, which in turn has created two very different concepts of interaction. Drawing on recent developments in the philosophy of science, Tabery offers a way to bridge this explanatory divide and these different concepts integratively. Looking to the future, Tabery evaluates the ethical issues that surround genetic testing for genes implicated in interactions of nature and nurture, pointing to what the future does (and does not) hold for a science that continues to make headlines and raise controversy.