The Male and Female Brain: Molecular Mechanisms of Sex Differences PDF Download

Author: Laura Musazzi
Publisher: Frontiers Media SA
ISBN: 2889718875
Category : Science
Languages : en
Pages : 218

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Author: Rebecca M. Shansky
Publisher: Academic Press
ISBN: 0128021985
Category : Science
Languages : en
Pages : 428

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Book Description
Sex Differences in the Central Nervous System offers a comprehensive examination of the current state of sex differences research, from both the basic science and clinical research perspectives. Given the current NIH directive that funded preclinical research must consider both females and males, this topic is of interest to an increasing percentage of the neuroscience research population. The volume serves as an invaluable resource, offering coverage of a wide range of topics: sex differences in cognition, learning, and memory, sex hormone signaling mechanisms, neuroimmune interactions, epigenetics, social behavior, neurologic disease, psychological disorders, and stress. Discussions of research in both animal models and human patient populations are included. Details how sex hormones have widespread effects on the nervous system and influence the way males and females function Assists readers in determining how sex impacts their research and practice, and assists in determining how to adjust research programs to incorporate sex influences Includes discussions of research in both animal models and human patient populations, and at various developmental stages Features revised and updated chapters by leaders in the field around the globe—the broadest, most expert coverage available

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 9780309132978
Category : Medical
Languages : en
Pages : 288

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Book Description
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Author: Maria Teresa Ferretti
Publisher: Academic Press
ISBN: 012819345X
Category : Medical
Languages : en
Pages : 514

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Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer’s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel

Author: Jill B. Becker
Publisher: Oxford University Press
ISBN: 0198042558
Category : Medical
Languages : en
Pages : 506

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Book Description
Within the basic and clinical biomedical research community, there is increasing recognition that differences between males and females across the lifespan affect an individual's health, his/her development of disease, signs and symptoms of pathophysiology, and response to therapy. This book is intended as a resource for scientists, clinicians, and students of the nervous system and behavior- a trove of practical information about how to study sex differences in the brain as well as a discussion of what is already known on the topic.

Author: Margaret McCarthy
Publisher: Biota Publishing
ISBN: 1615040617
Category : Medical
Languages : en
Pages : 110

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Book Description
The brains of males and females, men and women, are different—that is a fact. What is debated is how different and how important those differences are. Sex differences in the brain are determined by genetics, hormones, and experience, which in humans includes culture, society, and parental and peer expectations. The importance of nonbiological variables to sex differences in humans is paramount, making it difficult if not impossible to parse out those contributions that are truly biological. The study of animals provides us the opportunity to understand the magnitude and scope of biologically based sex differences in the brain and understanding the cellular mechanisms provides us insight into novel sources of brain plasticity. Many sex differences are established during a developmental sensitive window by differences in the hormonal milieu of males versus females. The neonatal testis produces large amounts of testosterone, which gains access to the brain and is further metabolized into active androgens and estrogens, which modify brain development. Major parameters that are influenced by hormones include neurogenesis, cell death, neurochemical phenotype, axonal and dendritic growth, and synaptogenesis. Variance in these parameters results in sex differences in the size of particular brain regions, the projections between brain regions, and the number and type of synapses within particular brain regions. The cellular mechanisms are both region and endpoint specific and invoke many surprising systems such as prostaglandins, endocannabinoids, and cell death proteins. By understanding when, why, and how sex differences in the brain are established, we may also learn the source of strong gender biases in the relative risk and severity of numerous neurological diseases and disorders of mental health, including but not limited to autism, dyslexia, attention deficit disorder, schizophrenia, Alzheimer’s, multiple sclerosis, Parkinson’s, and major depressive disorder. Table of Contents: Introduction / Sex Determination versus Sex Differentiation / Masculinization, Feminization, and Defeminization / Steroid Hormones Are Potent Modulators of Brain Development / Sex Differences in the Brain Are Established During a Developmental Sensitive Window / Sex Differences in Physiology and Behavior Are Coordinated / Knockouts of the Rule: Mice with Null Mutations of Steroid Receptors, Steroidogenic Enzymes, and Binding Proteins / Steroids Influence Multiple Endpoints to Organize the Brain / Cellular Mechanisms of Steroid-Mediated Organization of the Brain / Winged Messengers: Lessons from Birds and Flies / Sexual Differentiation of the Primate Brain / Sexual Differentiation of the Human Brain / Overcoming the Hegemony of Hormones: Genes Matter Too / The Value of Understanding the Effect of Sex on the Developing Brain / References

Author:
Publisher: Elsevier
ISBN: 9780444536310
Category : Science
Languages : en
Pages : 216

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This volume of Progress in Brain Research documents recent developments and research findings in relation to sex and how the brain’s function and behavior differs from men to women. Specific areas include cerebral function, morphology and organization, sexual dimorphism, neural origins,and genetics and epigenetics, as well as potential causes/affects of stress, pain, sexual orientation and identity and other social issues such as distribution of disorders across the sexes and autism. * Informs and updates on all the latest developments in the field * Highlights areas for future research * Contributions from leading authorities and industry experts

Author: Donald W. Pfaff
Publisher: Springer
ISBN: 9781493934737
Category : Medical
Languages : en
Pages : 0

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Book Description
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

Author: Robert W. Goy
Publisher: MIT Press (MA)
ISBN: 9780262572071
Category : Medical
Languages : en
Pages : 223

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Book Description
Investigating the relative importance of genes, hormones, and environment in the formation of sexual behavior.

Author: Fanny M. Cheung
Publisher: Cambridge University Press
ISBN: 1108602185
Category : Social Science
Languages : en
Pages : 1524

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Book Description
There is a growing knowledge base in understanding the differences and similarities between women and men, as well as the diversities among women and sexualities. Although genetic and biological characteristics define human beings conventionally as women and men, their experiences are contextualized in multiple dimensions in terms of gender, sexuality, class, age, ethnicity, and other social dimensions. Beyond the biological and genetic basis of gender differences, gender intersects with culture and other social locations which affect the socialization and development of women across their life span. This handbook provides a comprehensive and up-to-date resource to understand the intersectionality of gender differences, to dispel myths, and to examine gender-relevant as well as culturally relevant implications and appropriate interventions. Featuring a truly international mix of contributors, and incorporating cross-cultural research and comparative perspectives, this handbook will inform mainstream psychology of the international literature on the psychology of women and gender.