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Author: Kazuwa Nakao Publisher: Springer ISBN: 4431556516 Category : Science Languages : en Pages : 330
Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author: Kazuwa Nakao Publisher: Springer ISBN: 4431556516 Category : Science Languages : en Pages : 330
Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author: Richard P. Shefferson Publisher: Cambridge University Press ISBN: 1108138608 Category : Science Languages : en Pages : 445
Book Description
The existing theories on the evolution of senescence assume that senescence is inevitable in all organisms. However, recent studies have shown that this is not necessarily true. A better understanding of senescence and its underlying mechanisms could have far-reaching consequences for conservation and eco-evolutionary research. This book is the first to offer interdisciplinary perspectives on the evolution of senescence in many species, setting the stage for further developments. It brings together new insights from a wide range of scientific fields and cutting-edge research done on a multitude of different animals (including humans), plants and microbes, giving the reader a complete overview of recent developments and of the controversies currently surrounding the topic. Written by specialists from a variety of disciplines, this book is a valuable source of information for students and researchers interested in ageing and life history traits and populations.
Author: Bernard Swynghedauw Publisher: Springer ISBN: 3030151115 Category : Medical Languages : en Pages : 121
Book Description
This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
Author: Maryam Sarwat Publisher: Academic Press ISBN: 0128131888 Category : Science Languages : en Pages : 322
Book Description
Senescence Signalling and Control in Plants discusses the studies showing the importance of hormone action on developmental senescence. It shows the involvement of various signaling components (such as EIN2, LOX2) and transcription factors (such as oresara1 or ORE1) in controlling hormonal activity during senescence. Further, the involvement of various micro RNAs (miR164, miR319) in regulating leaf senescence are discussed. Through this book, the authors throw light on all the reverse and forward genetic approaches to reveal the role of various other phytohormones regulating plant senescence and the molecular mechanisms involved. Chapters on relevant topics are contributed by experts working in the area, making this a comprehensive treatise designed to provide an in-depth analysis on the subject matter. Throws light on the involvement of hormones (other than the well- known hormones cytokine and ethylene) in plant senescence Shows the underlying mechanisms on the hormonal actions during senescence Exhibits the involvement of microRNAs during this important plant developmental process
Author: Andrea Charise Publisher: SUNY Press ISBN: 1438477457 Category : Literary Criticism Languages : en Pages : 242
Book Description
Investigates how nineteenth-century British literature grappled with a new understanding of aging as both an individual and collective experience. The Aesthetics of Senescence investigates how chronological age has come to possess far-reaching ideological, ethical, and aesthetic implications, both in the past and present. Andrea Charise argues that authors of the nineteenth century used the imaginative resources of literature to engage with an unprecedented climate of crisis associated with growing old. Marshalling a great variety of canonical authors including William Godwin, Mary Shelley, George Eliot, Anthony Trollope, and George Gissing, as well as less familiar writings by George Henry Lewes, Christoph Wilhelm Hufeland, Agnes Strickland, and Max Nordau, Charise demonstrates why the imaginative capacity of writing became an interdisciplinary crucible for testing what it meant to grow old at a time of profound cultural upheaval. Charise’s grounding in medicine, political history, literature, and genre offers a fresh, original, thoroughly interdisciplinary analysis of nineteenth-century aging and age theory, as well as new insights into the rise of the novel—a genre usually thought of as affiliated almost entirely with the young or middle-aged. “Charise’s brilliantly argued, clearly written book is an important intervention in nineteenth-century British literature, age studies, and medical humanities. It brings these areas of inquiry together in what seems a seamless way—as if they have always traveled together or ought to have. Through an investigation of what she calls the ‘aesthetics of embodiment that shaped nineteenth-century visions of aging,’ Charise has given us an original and groundbreaking study of literary, historical, anthropological, and philosophical texts.” — Devoney Looser, author of The Making of Jane Austen
Author: Marco Demaria Publisher: Humana Press ISBN: 9781493989300 Category : Science Languages : en Pages : 253
Book Description
This book describes current methods for the identification and characterization of the major hallmarks of senescent cells. Chapters focus on the high heterogeneity of the senescence phenotypes, and techniques to induce and identify specific senescence programs. Additional chapters describe cellular and mouse models in which is possible to study the complex cell and non-cell autonomous functions of senescent cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cellular Senescence: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Caleb E. Finch Publisher: University of Chicago Press ISBN: 9780226248899 Category : Health & Fitness Languages : en Pages : 948
Book Description
Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
Author: L.D. Nooden Publisher: Elsevier ISBN: 0323145957 Category : Science Languages : en Pages : 564
Book Description
Senescence and Aging in Plants reviews the state of knowledge in the processes involved in plant senescence and aging. The book begins by discussing the emergence of senescence as a concept; experimental analysis of senescence; and patterns of senescence. It then examines membrane deterioration during senescence; photosynthesis in relation to leaf senescence; senescence of detached plant organs; changing patterns of nucleic acid and protein synthesis during senescence; and degradative and associated assimilatory aspects of nitrogen removal. This is followed by chapters on aspects of ethylene that may impinge upon its role in promoting senescence of higher plants; the role of cytokinins in plant senescence; the promoters and retardants of senescence; and the role of calcium in plant senescence. The concept of whole plant senescence is discussed, which can be subdivided into patterns, correlative controls, cessation of vegetative growth, declining assimilatory processes, assimilate partitioning, and hormonal controls. The final chapters cover the deterioration of cellular membranes during the plant aging process and seed aging.
Author: Suresh I.S. Rattan Publisher: Springer ISBN: 3319262394 Category : Medical Languages : en Pages : 364
Book Description
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.
Author: Kazuwa Nakao
Author: Kazuwa Nakao
Author: Richard P. Shefferson
Author: Bernard Swynghedauw
Author: Maryam Sarwat
Author: Andrea Charise
Author: Marco Demaria
Author: Caleb E. Finch
Author: L.D. Nooden
Author: Suresh I.S. Rattan
Author: Granville Stanley Hall