Author: Xian-Jun FuPublisher: Frontiers Media SA
ISBN: 2832525113
Category : Science
Languages : en
Pages : 220
Book Description
A new frontier for traditional medicine research - multi-omics approaches
Author: Xian-Jun FuPublisher: Frontiers Media SA
ISBN: 2832525113
Category : Science
Languages : en
Pages : 220
Book Description
Artificial Intelligence and Bioinformatics Applications for Omics and Multi-Omics Studies
Author: Angelo FacchianoPublisher: Frontiers Media SA
ISBN: 2832544452
Category : Science
Languages : en
Pages : 160
Book Description
Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: Current perspectives and new challenges.
Author: Basel A. Abdel-WahabPublisher: Frontiers Media SA
ISBN: 2832528619
Category : Science
Languages : en
Pages : 185
Book Description
Inflammatory immune disease: Molecular mechanisms, translational approaches and therapeutics volume II
Author: Tao XuPublisher: Frontiers Media SA
ISBN: 2832517161
Category : Science
Languages : en
Pages : 656
Book Description
The Characteristics of Pediatric Soft Tissue Sarcomas: Recent Advances in Management and Treatment
Author: Jilong YangPublisher: Frontiers Media SA
ISBN: 2832532829
Category : Medical
Languages : en
Pages : 138
Book Description
Sarcomas are forms of cancer that comprise tumors of the connective and structural tissue of the body and mainly affect children and young adults. Pediatric soft tissue sarcomas (STS) are a heterogeneous group of malignant tumors constituting about 7% of all cancer cases. Rhabdomyosarcomas (RMS) constitute about half of all soft tissue sarcomas in children, the rest being constituted by non- rhabdomyosarcoma soft tissue sarcomas (NRSTS). The estimated 5-year survival rate is around 65.6% in children and young adults, Rhabdomyosarcoma being as low as 59.2% in some cases.
Revolutions in Human Biospecimen Study: Leveraging new technologies to explore the pathology, therapeutics and biomarkers for atherosclerotic disease
Author: Ying WangPublisher: Frontiers Media SA
ISBN: 2832539351
Category : Medical
Languages : en
Pages : 141
Book Description
Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.
The New Frontier of Network Physiology: From Temporal Dynamics to the Synchronization and Principles of Integration in Networks of Physiological Systems
Author: Plamen Ch. IvanovPublisher: Frontiers Media SA
ISBN: 2889714357
Category : Science
Languages : en
Pages : 842
Book Description
IT Revolution
Author: Mihaela UlieruPublisher: Springer Science & Business Media
ISBN: 3642039782
Category : Computers
Languages : en
Pages : 270
Book Description
“Mitigating Paradox at the eSociety Tipping Point” In the first two decades of the past Century, having as driving factor the automobile and its mass production, the command economy has radically changed our lifestyles, enabling the creation of offices, suburbs, fast food restaurants and unified school d- tricts. With the Internet as driving factor, socio-technical and industrial eNetworked ecosystems are about to change our lives again in these two decades of the twenty-first century, and we are just approaching the tipping point. As we have just reached the point where the tremendous changes fueled by concerted efforts in information communication technologies (ICT) research are unraveling the old society this is creating a lot of d- comfort, confusion and sometimes opposition from the traditional mainstream. This disconnect is being deepened even more by the rocketing speed of technological ICT advances. As technology is getting ahead of society, the old ways, although still do- nant, become more and more dysfunctional and we are experiencing an "age of pa- dox" as the new ways disrupt the way we used to do things and even the way we used to think about the world. Just like the major inventions that shaped the last century were made by 1920, it is expected that the major inventions that will shape the twen- first century are going to be made by 2020.
Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases
Author: Min TangPublisher: Frontiers Media SA
ISBN: 2832506674
Category : Science
Languages : en
Pages : 224
Book Description
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
The Development and Application of Multi-Omics Integration Approaches to Dissecting Complex Traits in Plants
Author: Shang-Qian XiePublisher: Frontiers Media SA
ISBN: 2889761355
Category : Science
Languages : en
Pages : 342
Book Description