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Author: Richard K. Burt Publisher: Springer ISBN: 1461549876 Category : Medical Languages : en Pages : 419
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).
Author: Richard K. Burt Publisher: Springer ISBN: 1461549876 Category : Medical Languages : en Pages : 419
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).
Author: Gerard Socie Publisher: Academic Press ISBN: 0128134399 Category : Science Languages : en Pages : 430
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Author: Karl B. Neumann Publisher: Nova Publishers ISBN: 9781604560428 Category : Hematopoietic stem cells Languages : en Pages : 262
Book Description
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of haematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognised with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anaesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field.
Author: Emmanuel Katsanis Publisher: Frontiers Media SA ISBN: 2889745317 Category : Medical Languages : en Pages : 112
Book Description
Dr Patrick Hanley, a Topic Editor for this collection, is a co-founder and serves on the board of directors of Mana Therapeutics, a private biotech company focused on cellular therapy for AML. All other Topic Editors declare no competing interests with regards to the Research Topic.
Author: Taner Demirer Publisher: BoD – Books on Demand ISBN: 9535100130 Category : Science Languages : en Pages : 598
Book Description
This book documents the increased number of stem cell-related research, clinical applications, and views for the future. The book covers a wide range of issues in cell-based therapy and regenerative medicine, and includes clinical and preclinical chapters from the respected authors involved with stem cell studies and research from around the world. It complements and extends the basics of stem cell physiology, hematopoietic stem cells, issues related to clinical problems, tissue typing, cryopreservation, dendritic cells, mesenchymal cells, neuroscience, endovascular cells and other tissues. In addition, tissue engineering that employs novel methods with stem cells is explored. Clearly, the continued use of biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.
Author: Rosana Pelayo Publisher: BoD – Books on Demand ISBN: 9533079304 Category : Science Languages : en Pages : 480
Book Description
This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.
Author: Mary J. Laughlin Publisher: Springer Science & Business Media ISBN: 159259333X Category : Medical Languages : en Pages : 454
Book Description
Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
Author: Taner Demirer Publisher: BoD – Books on Demand ISBN: 9535109804 Category : Science Languages : en Pages : 382
Book Description
This book documents the increased number of stem cell related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world. It thereby complements and extends the basic coverage of stem cells such as immunogenetics, neuron replacement therapy, cover hematopoietic stem cells, issues related to clinical problems, advanced HLA typing, alternative donor sources as well as gene therapy that employs novel methods in this field. Clearly, the treatment of various malignancies and biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.
Author: Richard K. Burt
Author: Richard K. Burt
Author: Michele Malagola
Author: Gerard Socie
Author: Karl B. Neumann
Author: Emmanuel Katsanis
Author: Taner Demirer
Author: Rosana Pelayo
Author: Mary J. Laughlin
Author: Taner Demirer
Author: Ying-Jun Chang