Mathematical Biology: Modeling and Analysis PDF Download

Author: Avner Friedman
Publisher: American Mathematical Soc.
ISBN: 1470447150
Category : Biology
Languages : en
Pages : 100

View

Book Description
The fast growing field of mathematical biology addresses biological questions using mathematical models from areas such as dynamical systems, probability, statistics, and discrete mathematics. This book considers models that are described by systems of partial differential equations, and it focuses on modeling, rather than on numerical methods and simulations. The models studied are concerned with population dynamics, cancer, risk of plaque growth associated with high cholesterol, and wound healing. A rich variety of open problems demonstrates the exciting challenges and opportunities for research at the interface of mathematics and biology. This book primarily addresses students and researchers in mathematics who do not necessarily have any background in biology and who may have had little exposure to PDEs.

Author: Ching Shan Chou
Publisher: Springer
ISBN: 3319296388
Category : Mathematics
Languages : en
Pages : 172

View

Book Description
This book is based on a one semester course that the authors have been teaching for several years, and includes two sets of case studies. The first includes chemostat models, predator-prey interaction, competition among species, the spread of infectious diseases, and oscillations arising from bifurcations. In developing these topics, readers will also be introduced to the basic theory of ordinary differential equations, and how to work with MATLAB without having any prior programming experience. The second set of case studies were adapted from recent and current research papers to the level of the students. Topics have been selected based on public health interest. This includes the risk of atherosclerosis associated with high cholesterol levels, cancer and immune interactions, cancer therapy, and tuberculosis. Readers will experience how mathematical models and their numerical simulations can provide explanations that guide biological and biomedical research. Considered to be the undergraduate companion to the more advanced book "Mathematical Modeling of Biological Processes" (A. Friedman, C.-Y. Kao, Springer – 2014), this book is geared towards undergraduate students with little background in mathematics and no biological background.

Author: Fiona Palmer
Publisher:
ISBN: 9781639873548
Category :
Languages : en
Pages : 0

View

Book Description
Mathematical biology also known as biomathematics is the sub-field of biology which uses analysis, abstractions and mathematical models to study the principles that influence structure, development and behavior of living organisms. It uses techniques and tools of mathematics to understand complex, non-linear mechanisms in biology. It aims to create models and representations of biological processes which can be used in practical as well as theoretical research. Tools and techniques of applied mathematics are commonly used for creating such models. Some of the areas of research in this field are algebraic biology, complex systems biology, computational neuroscience, abstract relational biology and evolutionary biology. This book explores all the important aspects of this field in the present day scenario. It also strives to provide a fair idea about mathematical biology and to help develop a better understanding of the latest developments within the field. In this book, using case studies and examples, constant effort has been made to make the understanding of the difficult concepts of this discipline as easy and informative as possible, for the readers.

Author: Brian P. Ingalls
Publisher: MIT Press
ISBN: 0262545829
Category : Science
Languages : en
Pages : 423

View

Book Description
An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Author: Andreas Kremling
Publisher: CRC Press
ISBN: 1466567899
Category : Mathematics
Languages : en
Pages : 382

View

Book Description
Drawing on the latest research in the field, Systems Biology: Mathematical Modeling and Model Analysis presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are systematically applied in biotechnology. The first part of the book introduces biological basics, such as metabolism, signaling, gene expression, and control as well as mathematical modeling fundamentals, including deterministic models and thermodynamics. The text also discusses linear regression methods, explains the differences between linear and nonlinear regression, and illustrates how to determine input variables to improve estimation accuracy during experimental design. The second part covers intracellular processes, including enzymatic reactions, polymerization processes, and signal transduction. The author highlights the process–function–behavior sequence in cells and shows how modeling and analysis of signal transduction units play a mediating role between process and function. The third part presents theoretical methods that address the dynamics of subsystems and the behavior near a steady state. It covers techniques for determining different time scales, sensitivity analysis, structural kinetic modeling, and theoretical control engineering aspects, including a method for robust control. It also explores frequent patterns (motifs) in biochemical networks, such as the feed-forward loop in the transcriptional network of E. coli. Moving on to models that describe a large number of individual reactions, the last part looks at how these cellular models are used in biotechnology. The book also explains how graphs can illustrate the link between two components in large networks with several interactions.

Author: Sarah P. Otto
Publisher: Princeton University Press
ISBN: 1400840910
Category : Science
Languages : en
Pages : 745

View

Book Description
Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available

Author: Gerda de Vries
Publisher: SIAM
ISBN: 0898718252
Category : Mathematics
Languages : en
Pages : 307

View

Book Description
This is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology. Included is an integrated package of theoretical modeling and analysis tools, computational modeling techniques, and parameter estimation and model validation methods, with a focus on integrating analytical and computational tools in the modeling of biological processes. Divided into three parts, it covers basic analytical modeling techniques; introduces computational tools used in the modeling of biological problems; and includes various problems from epidemiology, ecology, and physiology. All chapters include realistic biological examples, including many exercises related to biological questions. In addition, 25 open-ended research projects are provided, suitable for students. An accompanying Web site contains solutions and a tutorial for the implementation of the computational modeling techniques. Calculations can be done in modern computing languages such as Maple, Mathematica, and MATLAB?.

Author: Valeria Zazzu
Publisher: Springer
ISBN: 3319234978
Category : Mathematics
Languages : en
Pages : 199

View

Book Description
This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy. The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content useful as it addresses existing challenges in identifying the gaps between mathematical modeling and biological research. The shared solutions will aid and promote further collaboration between life sciences and mathematics.

Author: Leah Edelstein-Keshet
Publisher: SIAM
ISBN: 9780898719147
Category : Mathematics
Languages : en
Pages : 629

View

Book Description
Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in this book are still important and informative. Audience: the book does not assume too much background knowledge--essentially some calculus and high-school algebra. It was originally written with third- and fourth-year undergraduate mathematical-biology majors in mind; however, it was picked up by beginning graduate students as well as researchers in math (and some in biology) who wanted to learn about this field.

Author: Sandip Banerjee
Publisher: CRC Press
ISBN: 1351022938
Category : Mathematics
Languages : en
Pages : 419

View

Book Description
Mathematical Modeling: Models, Analysis and Applications, Second Edition introduces models of both discrete and continuous systems. This book is aimed at newcomers who desires to learn mathematical modeling, especially students taking a first course in the subject. Beginning with the step-by-step guidance of model formulation, this book equips the reader about modeling with difference equations (discrete models), ODE’s, PDE’s, delay and stochastic differential equations (continuous models). This book provides interdisciplinary and integrative overview of mathematical modeling, making it a complete textbook for a wide audience. A unique feature of the book is the breadth of coverage of different examples on mathematical modelling, which include population models, economic models, arms race models, combat models, learning model, alcohol dynamics model, carbon dating, drug distribution models, mechanical oscillation models, epidemic models, tumor models, traffic flow models, crime flow models, spatial models, football team performance model, breathing model, two neuron system model, zombie model and model on love affairs. Common themes such as equilibrium points, stability, phase plane analysis, bifurcations, limit cycles, period doubling and chaos run through several chapters and their interpretations in the context of the model have been highlighted. In chapter 3, a section on estimation of system parameters with real life data for model validation has also been discussed. Features Covers discrete, continuous, spatial, delayed and stochastic models. Over 250 illustrations, 300 examples and exercises with complete solutions. Incorporates MATHEMATICA® and MATLAB®, each chapter contains Mathematica and Matlab codes used to display numerical results (available at CRC website). Separate sections for Projects. Several exercise problems can also be used for projects. Presents real life examples of discrete and continuous scenarios. The book is ideal for an introductory course for undergraduate and graduate students, engineers, applied mathematicians and researchers working in various areas of natural and applied sciences.