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Author: John E.G. McCarthy Publisher: Springer Science & Business Media ISBN: 3642751393 Category : Science Languages : en Pages : 650
Book Description
The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques that began in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all levels. The resulting investigations revealed a diversity of post-transcriptional mechanisms in both prokaryotes and eukaryotes. Scientists working on translation, mRNA stability, transcriptional (anti)termination or other aspects of gene expression will often have met at specialist meetings for their own research area. However, only rarely do workers in different areas of post-transcriptional control/ regulation have the opportunity to meet under one roof. We therefore thought it was time to bring together leading representatives of most of the relevant areas in a small workshop intended to encourage interaction across the usual borders of research, both in terms of the processes studied, and with respect to the evolutionary division prokaryotes/eukaryotes. Given the breadth of topics covered and the restrictions in size imposed by the NATO workshop format, it was an extraordinarily difficult task to choose the participants. However, we regarded this first attempt as an experiment on a small scale, intended to explore the possibilities of a meeting of this kind. Judging by the response of the participants during and after the workshop, the effort had been worthwhile.
Author: John E.G. McCarthy Publisher: Springer Science & Business Media ISBN: 3642751393 Category : Science Languages : en Pages : 650
Book Description
The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques that began in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all levels. The resulting investigations revealed a diversity of post-transcriptional mechanisms in both prokaryotes and eukaryotes. Scientists working on translation, mRNA stability, transcriptional (anti)termination or other aspects of gene expression will often have met at specialist meetings for their own research area. However, only rarely do workers in different areas of post-transcriptional control/ regulation have the opportunity to meet under one roof. We therefore thought it was time to bring together leading representatives of most of the relevant areas in a small workshop intended to encourage interaction across the usual borders of research, both in terms of the processes studied, and with respect to the evolutionary division prokaryotes/eukaryotes. Given the breadth of topics covered and the restrictions in size imposed by the NATO workshop format, it was an extraordinarily difficult task to choose the participants. However, we regarded this first attempt as an experiment on a small scale, intended to explore the possibilities of a meeting of this kind. Judging by the response of the participants during and after the workshop, the effort had been worthwhile.
Author: Erik Dassi Publisher: Humana ISBN: 9781071618530 Category : Science Languages : en Pages : 0
Book Description
This volume presents the most recent advances in techniques for studying the post-transcriptional regulation of gene expression (PTR). With sections on bioinformatics approaches, expression profiling, the protein and RNA interactome, the mRNA lifecycle, and RNA modifications, the book guides molecular biologists toward harnessing the power of this new generation of techniques, while also introducing the data analysis skills that these high-throughput techniques require. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Post-Transcriptional Gene Regulation, Third Edition serves as a versatile resource for researchers studying post-transcriptional regulation by both introducing the most recent techniques and providing a comprehensive guide to their implementation. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Orna Resnekov Publisher: Springer Science & Business Media ISBN: 3642609295 Category : Science Languages : en Pages : 276
Book Description
Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Author: Jane Wu Publisher: ISBN: 9783527665433 Category : Science Languages : en Pages : 0
Book Description
2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations.
Author: Witold Filipowicz Publisher: Springer Science & Business Media ISBN: 9400903537 Category : Science Languages : en Pages : 419
Book Description
A recent volume of this series (Signals and Signal Transduction Pathways in Plants (K. Palme, ed.) Plant Molecular Biology 26, 1237-1679) described the relay races by which signals are transported in plants from the sites of stimuli to the gene expression machinery of the cell. Part of this machinery, the transcription apparatus, has been well studied in the last two decades, and many important mechanisms controlling gene expression at the transcriptional level have been elucidated. However, control of gene expression is by no means complete once the RNA has been produced. Important regulatory devices determine the maturation and usage of mRNA and the fate of its translation product. Post-transcriptional regulation is especially important for generating a fast response to environmental and intracellular signals. This book summarizes recent progress in the area of post-transcriptional regulation of gene expression in plants. 18 chapters of the book address problems of RNA processing and stability, regulation of translation, protein folding and degradation, as well as intracellular and cell-to-cell transport of proteins and nucleic acids. Several chapters are devoted to the processes taking place in plant organelles.
Author: Paolo Sassone-Corsi Publisher: Springer ISBN: 3319270699 Category : Medical Languages : en Pages : 132
Book Description
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Author: Ghedira Kais Publisher: BoD – Books on Demand ISBN: 1789237912 Category : Medical Languages : en Pages : 136
Book Description
This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
Author: John E.G. McCarthy
Author: John E.G. McCarthy
Author: Erik Dassi
Author: Bruce Alberts
Author: Orna Resnekov
Author: Jane Wu
Author: Witold Filipowicz
Author: Paolo Sassone-Corsi
Author: 
Author: Ghedira Kais
Author: Jeffrey Wilusz