Memory Development for Individuals with Down Syndrome PDF Download

Author: Sue Buckley
Publisher: DSE Enterprises
ISBN: 1903806089
Category : Children with disabilities
Languages : en
Pages : 46

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Author: Marie-Claude Potier
Publisher: Frontiers Media SA
ISBN: 2889450457
Category : Electronic book
Languages : en
Pages : 183

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Book Description
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Author: Susan E. Gathercole
Publisher: Psychology Press
ISBN: 1317775279
Category : Psychology
Languages : en
Pages : 284

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This book evaluates the involvement of working memory in five central aspects of language processing: vocabulary acquisition, speech production, reading development, skilled reading, and comprehension. The authors draw upon experimental, neuropsychological and developmental evidence in a wide-ranging evaluation of the contribution of two components of working memory to each aspect of language. The two components are the phonological loop, which is specialised for the processing and maintenance of verbal material, and the general-purpose processing system of the central executive. A full introduction to the application of the working memory model to normal adults, neuropsychological patients and children is provided in the two opening chapters. Non-experts within this area will find these chapters particularly useful in providing a clear statement of the current theoretical and empirical status of the working memory model. Each of the following chapters examines the involvement of working memory in one specialised aspect of language processing, in each case integrating the available experimental, neuropsychological and developmental evidence. The book will therefore be of direct relevance to researchers interested in both language processing and memory. Working Memory and Language is unique in that it draws together findings from normal adults, brain-damaged patients, and children. For each of these populations, working memory involvement in language processing ranging from the speech production to comprehension are evaluated. Working Memory and Language provides a comprehensive analysis of just what roles working memory does play in the processing of language.

Author: William I. Cohen
Publisher: John Wiley & Sons
ISBN: 0471461229
Category : Health & Fitness
Languages : en
Pages : 493

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Der Band bietet einen aktuellen Überblick über klinische, entwicklungsbezogene, psychosoziale, erziehungs- und berufsbezogene Fragen bei Patienten mit Down Syndrom. Er diskutiert auch die Konsequenzen des Human-Genom-Projektes und die Sequenzierung des Chromosom 21. Erörtert aktuellste Entwicklungen, u.a. zum Thema Sexualität, Einbeziehung, Übergang ins Erwachsenenalter und Rechtsprechung. Behandelt die aktuellsten Neuerungen der "Health Care Guidelines for Individuals with Down Syndrome". Enthält auch Material zu mitunter kontrovers diskutierten alternativen und unkonventionellen Therapieansätzen.

Author: Jacob A. Burack
Publisher: Oxford University Press
ISBN: 019064544X
Category : Education
Languages : en
Pages : 681

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Book Description
"The chapter traces some key historical developments in the field of Down syndrome. After describing general issues of classification in intellectual disabilities, we describe Langdon Down's identification of the syndrome in the 1860s; the movement to name the syndrome after Down; the identification of trisomy 21 as the syndrome's cause; and the beginnings of sustained research attention to the syndrome. We end with a glimpse into the future, discussing issues of longer life spans, more integrated lives, and the roles of families, organizations, and self-advocates. Working together, researchers, practitioners, and individuals and their families can all continue to advance the lives of persons with Down syndrome"--

Author: Dante Cicchetti
Publisher: Cambridge University Press
ISBN: 9780521386678
Category : Medical
Languages : en
Pages : 492

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Book Description
This volume offers a state-of-art review of what is known about young children with Down syndrome from a developmental perspective. The underlying theme of the book is that children with Down syndrome, despite their constitutional anomalies and their additional medical and biological problems, can be understood from a normative developmental framework. Interventions guided by developmental principles in the biological, educational and psychological realms are more likely to result in informed knowledge about how best to help children with Down syndrome and their families. Children with Down Syndrome will appeal to researchers, theoreticians, educators, and clinicians in a range of disciplines, as well as to parents, social policymakers, and other advocates for the best interests of children with Down syndrome.

Author:
Publisher: Elsevier
ISBN: 0444543007
Category : Medical
Languages : en
Pages : 273

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Book Description
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author: Charles Hulme
Publisher: Psychology Press
ISBN: 1317748425
Category : Psychology
Languages : en
Pages : 148

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"Working memory" is a term used to refer to the systems responsible for the temporary storage of information during the performance of cognitive tasks. The efficiency of working memory skills in children may place limitations on the learning and performance of educationally important skills such as reading, language comprehension and arithmetic. Originally published in 1992, this monograph considers the development of working memory skills in children with severe learning difficulties. These children have marked difficulties with a wide range of cognitive tasks. The studies reported show that they also experience profound difficulties in verbal working memory tasks. These memory problems are associated with a failure to rehearse information within an articulatory loop. Training the children to rehearse material is shown to help alleviate these problems. The implications of these studies for understanding normal memory development, and for models of the structure of working memory and its development are discussed. It is argued that the working memory deficits seen in people with severe learning difficulties may contribute to their difficulties on other cognitive tasks.

Author: Sue Buckley
Publisher: DSE Enterprises
ISBN: 1903806038
Category : Children with disabilities
Languages : en
Pages : 46

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Book Description
This book offers an introduction to the development of infants with Down syndrome. Drawing on the latest research and extensive practical experience, it examines many aspects of development during the early years. Presented in an accessible format, it is a useful reference for families and professionals caring for young children with Down syndrome. This introductory book provides an overview of development from birth. It provides information about the development of social, motor, language, cognitive, play, attention, behaviour and self-help skills. It also details typical milestones for children with Down syndrome in these areas. The book highlights the influence of the family and the social interactive nature of development. Individual differences are discussed, as are key health and family issues. Principles for early intervention, therapy and education services are identified, based on the specific needs of children with Down syndrome and research on effectiveness. Down Syndrome Issues and Information is a major series of practical and informative books covering the full range of developmental, health and social issues relating to individuals with Down syndrome. based on years of research and hands-on experience.

Author: Vee Prasher
Publisher: CRC Press
ISBN: 1315345382
Category : Medical
Languages : en
Pages : 249

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Book Description
This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.