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Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan

Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan PDF Author: Annibale Puca
Publisher: MDPI
ISBN: 3036509801
Category : Science
Languages : en
Pages : 204

Book Description
People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.

Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan

Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan PDF Author: Annibale Puca
Publisher: MDPI
ISBN: 3036509801
Category : Science
Languages : en
Pages : 204

Book Description
People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.

Centenarians--A Model to Study the Molecular Basis of Lifespan and Healthspan

Centenarians--A Model to Study the Molecular Basis of Lifespan and Healthspan PDF Author: Annibale Puca
Publisher:
ISBN: 9783036509815
Category :
Languages : en
Pages : 204

Book Description
People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.

Handbook of Anti-Aging Medicine

Handbook of Anti-Aging Medicine PDF Author: Prof Dr Mike KS Chan
Publisher: EUROPEAN WELLNESS ACADEMY
ISBN: 1662930216
Category : Medical
Languages : en
Pages : 607

Book Description
This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.

Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals

Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals PDF Author: Deep Pooja
Publisher: Springer Nature
ISBN: 9819953146
Category : Medical
Languages : en
Pages : 353

Book Description
This book explores the role of nanotechnology in the delivery of natural phytoconstituents and cosmeceuticals. It presents polymeric nanocarriers, lipid-based nanocarriers, metal/metal oxide nanocarriers, protein nanocarriers, and dendrimers for the delivery of phytoconstituents. Further, it focuses on the usage of phytocompounds in various cosmeceutical products and nano delivery technologies used in the delivery of various cosmeceuticals. Finally, the book reviews the toxicity issues of nanoparticles in the delivery of phytoconstituents and cosmeceuticals and regulatory aspects for clinical applications of nano phytomedicines. This book is helpful for academicians and researchers working in pharmaceutical sciences, nano science, material science, plant science, and cosmetic science.

Exceptional Longevity

Exceptional Longevity PDF Author: Bernard Jeune
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 180

Book Description
States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.

Current Perspectives on Centenarians

Current Perspectives on Centenarians PDF Author: Raya Elfadel Kheirbek
Publisher: Springer Nature
ISBN: 3031309154
Category : Social Science
Languages : en
Pages : 273

Book Description
This book explores various aspects related to human longevity and aging beyond 100 years old. It examines all domains of health and well-being of this elite group including the current demographics, genetics and epigenetics of exceptional longevity, cardiovascular risk factors, dementia, nutrition, physical activity, African American and Hispanic centenarians, financial planning, religion, spirituality, whole health, wellness, oral health, and nature. The book also delves into the lives of supercentenarians, defined as expert survivors who have lived beyond 110 years old. The implications of the Age-Friendly Healthcare Systems (AFHS) Movement on the care of centenarians are also discussed. This book is a valuable resource for healthcare professionals, epidemiologists, public health professionals, policy makers, and anyone interested in the study of aging and longevity.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity PDF Author: Alexey Moskalev
Publisher: Academic Press
ISBN: 012811083X
Category : Medical
Languages : en
Pages : 544

Book Description
Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Aging

Aging PDF Author: Stuart Jay Olshansky
Publisher:
ISBN: 9781621820802
Category : MEDICAL
Languages : en
Pages : 0

Book Description
"Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Molecular Basis and Emerging Strategies for Anti-aging Interventions PDF Author: Syed Ibrahim Rizvi
Publisher: Springer
ISBN: 9811316996
Category : Medical
Languages : en
Pages : 386

Book Description
This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging PDF Author: Marco Malavolta
Publisher: Academic Press
ISBN: 0128018275
Category : Science
Languages : en
Pages : 784

Book Description
Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition