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Of Mice, Models, and Men

Of Mice, Models, and Men PDF Author: Andrew N. Rowan
Publisher: State University of New York Press
ISBN: 1438418116
Category : Social Science
Languages : en
Pages : 344

Book Description
Too much emotion and insufficient fact. This paradox has long characterized the controversy surrounding animal research. Of Mice, Models, and Men is the first exhaustive treatment of all areas—empirical and conceptual—relevant to the use of animals in research. It is also the first study to combine regard for the welfare of laboratory animals with a knowledgeable acceptance of the continuing need for research involving animals. The book has another rare quality. It is virtually devoid of any of the emotional and exaggerated attacks that have characterized many of the other publications in this area. Instead, it presents, in a manner accessible to both sides, all the relevant historical, social, and scientific information required to form an opinion on the subject. The book thus achieves a most difficult goal—that of bridging the gap between researchers using animals and animal welfare advocates, while pointing out the need for a more active program to promote laboratory animal welfare.

Of Mice, Models, and Men

Of Mice, Models, and Men PDF Author: Andrew N. Rowan
Publisher: State University of New York Press
ISBN: 1438418116
Category : Social Science
Languages : en
Pages : 344

Book Description
Too much emotion and insufficient fact. This paradox has long characterized the controversy surrounding animal research. Of Mice, Models, and Men is the first exhaustive treatment of all areas—empirical and conceptual—relevant to the use of animals in research. It is also the first study to combine regard for the welfare of laboratory animals with a knowledgeable acceptance of the continuing need for research involving animals. The book has another rare quality. It is virtually devoid of any of the emotional and exaggerated attacks that have characterized many of the other publications in this area. Instead, it presents, in a manner accessible to both sides, all the relevant historical, social, and scientific information required to form an opinion on the subject. The book thus achieves a most difficult goal—that of bridging the gap between researchers using animals and animal welfare advocates, while pointing out the need for a more active program to promote laboratory animal welfare.

Of Flies, Mice, and Men

Of Flies, Mice, and Men PDF Author: François Jacob
Publisher: Harvard University Press
ISBN: 9780674631113
Category : Science
Languages : en
Pages : 178

Book Description
"Tells the story of how the marvelous discoveries of molecular and developmental biology are transforming our understanding of who we are and where we came from. Jacob scrutinizes the place of the scientist in society". -- Jacket.

Genetics of Human Infertility

Genetics of Human Infertility PDF Author: P.H. Vogt
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060984
Category : Medical
Languages : en
Pages : 178

Book Description
Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Of Mice and Men

Of Mice and Men PDF Author: John Steinbeck
Publisher: Penguin
ISBN: 9780140186420
Category : Fiction
Languages : en
Pages : 148

Book Description
A controversial tale of friendship and tragedy during the Great Depression A Penguin Classic Over seventy-five years since its first publication, Steinbeck’s tale of commitment, loneliness, hope, and loss remains one of America’s most widely read and taught novels. An unlikely pair, George and Lennie, two migrant workers in California during the Great Depression, grasp for their American Dream. They hustle work when they can, living a hand-to-mouth existence. For George and Lennie have a plan: to own an acre of land and a shack they can call their own. When they land jobs on a ranch in the Salinas Valley, the fulfillment of their dream seems to be within their grasp. But even George cannot guard Lennie from the provocations, nor predict the consequences of Lennie's unswerving obedience to the things George taught him. Of Mice and Men represents an experiment in form, which Steinbeck described as “a kind of playable novel, written in a novel form but so scened and set that it can be played as it stands.” A rarity in American letters, it achieved remarkable success as a novel, a Broadway play, and three acclaimed films. This edition features an introduction by Susan Shillinglaw, one of today’s leading Steinbeck scholars. For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.

Guide for the Care and Use of Laboratory Animals

Guide for the Care and Use of Laboratory Animals PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309154006
Category : Science
Languages : en
Pages : 246

Book Description
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038391
Category : Science
Languages : en
Pages : 113

Book Description
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

World as Laboratory

World as Laboratory PDF Author: Rebecca Lemov
Publisher: Hill and Wang
ISBN: 0374707294
Category : Science
Languages : en
Pages : 376

Book Description
Deeply researched, World as Laboratory tells a secret history that's not really a secret. The fruits of human engineering are all around us: advertising, polls, focus groups, the ubiquitous habit of "spin" practiced by marketers and politicians. What Rebecca Lemov cleverly traces for the first time is how the absurd, the practical, and the dangerous experiments of the human engineers of the first half of the twentieth century left their laboratories to become our day-to-day reality.

Issues in Men's Health and Medicine: 2012 Edition

Issues in Men's Health and Medicine: 2012 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1481649833
Category : Medical
Languages : en
Pages : 28

Book Description
Issues in Men's Health and Medicine: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Men's Health in a compact format. The editors have built Issues in Men's Health and Medicine: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Men's Health in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Men's Health and Medicine: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Recognition and Alleviation of Distress in Laboratory Animals

Recognition and Alleviation of Distress in Laboratory Animals PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309108179
Category : Science
Languages : en
Pages : 137

Book Description
Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.

Making Mice

Making Mice PDF Author: Karen Rader
Publisher: Princeton University Press
ISBN: 0691187584
Category : Science
Languages : en
Pages :

Book Description
Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.