Author: Publisher: DIANE Publishing
ISBN: 1428904646
Category :
Languages : en
Pages : 52
Book Description
Program review report of the Board of Scientific Counselors endocrine disrupting chemicals (EDC) research program
Author: Publisher: DIANE Publishing
ISBN: 1428904646
Category :
Languages : en
Pages : 52
Book Description
Program Review Report of the Board of Scientific Counselors Endocrine Disrupting Chemicals (EDC) Research Program
Author: Publisher:
ISBN:
Category : Endocrine disrupting chemicals
Languages : en
Pages : 52
Book Description
Environmental Health Perspectives
Author: Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 676
Book Description
Program Review Report of the Board of Scientific Counselors Human Health Research Program
Author: Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 56
Book Description
Interior, Environment, and Related Agencies Appropriations for 2011, Part 3, 111-2 Hearings
Author: Review of the Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response Relationships as they Apply to Endocrine Disruptors
Author: National Research CouncilPublisher: National Academies Press
ISBN: 0309297575
Category : Nature
Languages : en
Pages : 64
Book Description
Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.
Endocrine-disrupting Chemicals in Drinking Water
Author: United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Energy and EnvironmentPublisher:
ISBN:
Category : Endocrine disrupting chemicals in water
Languages : en
Pages : 192
Book Description
Environment Reporter
Author: NTP, Current Directions and Evolving Strategies
Author: National Toxicology Program (U.S.)Publisher:
ISBN:
Category : Toxicology
Languages : en
Pages : 36
Book Description
Integrity in Scientific Research
Author: National Research CouncilPublisher: National Academies Press
ISBN: 0309169283
Category : Science
Languages : en
Pages : 216
Book Description
"Many people say that it is the intellect which makes a great scientist. They are wrong: it is character."-Albert Einstein Integrity in Scientific Research attempts to define and describe those elements that encourage individuals involved with scientific research to act with integrity. Recognizing the inconsistency of human behavior, it stresses the important role that research institutions play in providing an integrity-rich environment, citing the need for institutions to provide staff with training and education, policies and procedures, and tools and support systems. It identifies practices that characterize integrity in such areas as peer review and research on human subjects and weighs the strengths and limitations of self-evaluation efforts by these institutions. In addition, it details an approach to promoting integrity during the education of researchers, including how to develop an effective curriculum. Providing a framework for research and educational institutions, this important book will be essential for anyone concerned about ethics in the scientific community.