Targeting Cardiac Proteotoxicity PDF Download

Author: Xuejun Wang
Publisher: Frontiers Media SA
ISBN: 2889668061
Category : Science
Languages : en
Pages : 175

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Author: Jun Ren
Publisher: Frontiers Media SA
ISBN: 2889715833
Category : Science
Languages : en
Pages : 310

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Author: H. Böhles
Publisher: CRC Press
ISBN: 9783887631048
Category : Cardiomyopathy
Languages : en
Pages : 188

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Book Description
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Author: Steven Grant
Publisher: Academic Press
ISBN: 0123943876
Category : Business & Economics
Languages : en
Pages : 290

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Book Description
Provides information on the exciting and fast-moving field of cancer research.

Author: Lorrie A. Kirshenbaum
Publisher: Springer Nature
ISBN: 3030787990
Category : Science
Languages : en
Pages : 293

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Book Description
One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.

Author: Huabo Su
Publisher: Frontiers Media SA
ISBN: 2889715000
Category : Science
Languages : en
Pages : 150

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Author: L. Maximilian Buja
Publisher: Academic Press
ISBN: 0323912583
Category : Science
Languages : en
Pages : 996

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Book Description
Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field. Includes expanded coverage of diagnostic guidelines, standards and normal values Provides a summary of cardiac catheterization laboratory and diagnostic imaging tests to guide pathologists in clinicopathological correlation Presents a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows in pathology, cardiology, cardiac surgery, and internal medicine Provides comprehensive coverage, including, when appropriate, Central Concept Figure, Definition, Epidemiology, Clinical Presentation, Pathogenesis, Molecular Genetics, Light and Electron Microscopy, Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications, and a Bulleted Summary

Author: John Lynn Jefferies
Publisher: Academic Press
ISBN: 0128005807
Category : Medical
Languages : en
Pages : 418

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Book Description
Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40’s-50’s and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health. Reveals the link between cardiac muscle disease and skeletal muscle disease Explains how genetics and environmental factors effect muscle function of diverse origins Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems

Author: Benzhi Cai
Publisher: Frontiers Media SA
ISBN: 2889740900
Category : Science
Languages : en
Pages : 727

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Author: VijayaKumar Sukumaran
Publisher: Frontiers Media SA
ISBN: 2889764974
Category : Medical
Languages : en
Pages : 185

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