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Author: James C. Wang Publisher: ISBN: Category : DNA topoisomerases Languages : en Pages : 252
Book Description
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
Author: James C. Wang Publisher: ISBN: Category : DNA topoisomerases Languages : en Pages : 252
Book Description
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
Author: Luca Mora Publisher: Elsevier ISBN: 0128154780 Category : Computers Languages : en Pages : 414
Book Description
Untangling Smart Cities: From Utopian Dreams to Innovation Systems for a Technology-Enabled Urban Sustainability helps all key stakeholders understand the complex and often conflicting nature of smart city research, offering valuable insights for designing and implementing strategies to improve the smart city decision-making processes. The book drives the reader to a better theoretical and practical comprehension of smart city development, beginning with a thorough and systematic analysis of the research literature published to date. It addition, it provides an in-depth understanding of the entire smart city knowledge domain, revealing a deeply rooted division in its cognitive-epistemological structure as identified by bibliometric insights. Users will find a book that fills the knowledge gap between theory and practice using case study research and empirical evidence drawn from cities considered leaders in innovative smart city practices. Provides clarity on smart city concepts and strategies Presents a systematic literature analysis on the state-of-the-art of smart cities' research using bibliometrics combined with practical applications Offers a comprehensive and systematic analysis of smart cities research produced during its first three decades Generates a strong connection between theory and practice by providing the scientific knowledge necessary to approach the complex nature of smart cities Documents five main development pathways for smart cities development, serving the needs of city managers and policymakers with concrete advice and guidance
Author: Pier Luigi Gentili Publisher: CRC Press ISBN: 0429847556 Category : Mathematics Languages : en Pages : 568
Book Description
Complex Systems are natural systems that science is unable to describe exhaustively. Examples of Complex Systems are both unicellular and multicellular living beings; human brains; human immune systems; ecosystems; human societies; the global economy; the climate and geology of our planet. This book is an account of a marvelous interdisciplinary journey the author made to understand properties of the Complex Systems. He has undertaken his trip, equipped with the fundamental principles of physical chemistry, in particular, the Second Law of Thermodynamics that describes the spontaneous evolution of our universe, and the tools of Non-linear dynamics. By dealing with many disciplines, in particular, chemistry, biology, physics, economy, and philosophy, the author demonstrates that Complex Systems are intertwined networks, working in out-of-equilibrium conditions, which exhibit emergent properties, such as self-organization phenomena and chaotic behaviors in time and space.
Author: Jordanka Zlatanova Publisher: Taylor & Francis ISBN: 1000822923 Category : Science Languages : en Pages : 732
Book Description
Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features · Highlights the experimental basis of important discoveries in molecular biology. · Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense. · Provides learning objectives for each chapter. · Includes a list of relevant videos from the Internet about the topics covered in the chapter.
Author: Ahamed Kutty Publisher: Page Publishing Inc ISBN: 1645448444 Category : Religion Languages : en Pages : 123
Book Description
Human beings generally attribute any physical, mental, or financial catastrophe to the random punitive decree of God, including death. All religions speak about destiny. In this book, I have demonstrated that whatever happens to us are determined by our genetic makeup and the DNA. Of course, the genes and DNA are created by God Himself who is the cause of all causations. In different religions, there is mention of an angel of death, whether this angels causes death or just receives the soul at the time of death is not clear. I have pointed out that natural cause of death is a function of the deteriorating telomere at the end of the chromosome. The other deaths due to accidents, epidemics, famine, and natural disasters are due to natural causes and is self-explanatory. I have mentioned the influence of epigenetics in our gene expression. The influence of epigenetics was recently confirmed in space travel as reported by NASA. This book also alludes to the fact that God does not interfere in our day-to-day activities and that is left for our free will.
Author: Alexander Vologodskii Publisher: Cambridge University Press ISBN: 1107034930 Category : Science Languages : en Pages : 279
Book Description
This book surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.
Author: Mark Deakin Publisher: Elsevier ISBN: 0128154772 Category : Computers Languages : en Pages : 416
Book Description
Untangling Smart Cities: From Theory to Practice helps all key stakeholders understand the complex and often conflicting nature of smart city research, offering valuable insights for designing and implementing strategies to improve the smart city decision-making processes. The book drives the reader to a better theoretical and practical comprehension of smart city development, beginning with a thorough and systematic analysis of the research literature published to date. The book provides an in-depth understanding of the entire smart city knowledge domain, revealing a deeply rooted division in its cognitive-epistemological structure as identified by bibliometric insights. Untangling Smart Cities fills the knowledge gap between theory and practice using case study research, with empirical evidence drawn from cities considered leaders in innovative smart city practices. An invaluable contribution to the growing scientific literature, Untangling Smart Cities provides an accurate and deep understanding of the strategic principles driving smart city development. Provides clarity on the smart city concepts and strategies Provides a systematic literature analysis on the state-of-the-art of Smart Cities research using bibliometrics combined with practical application to guide smart systems implementation Offers a comprehensive and systematic analysis of Smart Cities research produced during its first three decades, driven by statistical analysis techniques Generates a strong connection between theory and practice by providing the scientific knowledge necessary to approach the complex nature of Smart Cities sourced from the analysis of actual best practices Documents five main development pathways for smart cities development, serving the needs of city managers and policy makers with concrete advice and guidance
Author: Gail Letzter Publisher: Springer ISBN: 3319341391 Category : Mathematics Languages : en Pages : 436
Book Description
Presenting the latest findings in topics from across the mathematical spectrum, this volume includes results in pure mathematics along with a range of new advances and novel applications to other fields such as probability, statistics, biology, and computer science. All contributions feature authors who attended the Association for Women in Mathematics Research Symposium in 2015: this conference, the third in a series of biennial conferences organized by the Association, attracted over 330 participants and showcased the research of women mathematicians from academia, industry, and government.
Author: Quan Li Publisher: John Wiley & Sons ISBN: 3527344829 Category : Technology & Engineering Languages : en Pages : 496
Book Description
This book covers the design, synthesis, properties, and applications of functional photoactive soft materials, including aspects of polymers, block copolymers, elastomers, biomaterials, liquid crystals, chemical and physical gels, colloids, and host-guest systems. It combines, in a unified manner, authoritative accounts describing various structural and functional aspects of photoactive soft materials. Photoactive Functional Soft Materials: Preparation, Properties, and Applications: * Brings together the state-of-the-art knowledge on photoactive functional soft materials in a unified manner * Covers a vibrant research field with tremendous application potential in areas such as optoelectronics, photonics, and energy generation * Appeals to a large interdisciplinary audience because it is highly useful for researchers and engineers working on photonics, optoelectronics, imaging and sensing, nanotechnology, and energy materials Photoactive Functional Soft Materials: Preparation, Properties and Applications focuses on the design and fabrication of photoactive functional soft materials for materials science, nanophotonics, nanotechnology, and biomedical applications.
Author: James C. Wang
Author: James C. Wang
Author: Luca Mora
Author: Pier Luigi Gentili
Author: Bruce Alberts
Author: Jordanka Zlatanova
Author: Ahamed Kutty
Author: Alexander Vologodskii
Author: Mark Deakin
Author: Gail Letzter
Author: Quan Li