Acute Lung Injury: Understanding the Mechanisms of Injury and Repair PDF Download

Author: Margaux Conference on Critical Illness. 4, 2002, Sintra
Publisher:
ISBN:
Category :
Languages : en
Pages : 160

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Author: Lynn M. Schnapp
Publisher: Humana Press
ISBN: 3319465279
Category : Medical
Languages : en
Pages : 185

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Book Description
Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ​

Author: Didier Dreyfuss
Publisher: CRC Press
ISBN: 1420019260
Category : Medical
Languages : en
Pages : 776

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Book Description
This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at risk for VILI.

Author: Geoffrey J. Bellingan
Publisher: John Wiley & Sons
ISBN: 9789051995039
Category : Animal welfare
Languages : en
Pages : 154

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Book Description
This book provides a comprehensive and up to date picture of the molecular mechanisms underlying acute lung injury, focusing both on the mechanisms of injury and of repair. Topics covered include the cells involved, their injurious products including pro-inflammatory cytokines, proteases and free radical species as well as the fibrotic response and its molecular regulation, the role of the immune system, airway repair and remodelling and transcription factors regulating inflammation. All the chapters are written by experts in their field and reflect the lecture given by these authors at a recent international meeting also entitled " Acute lung injury: from inflammation to repair", held as part of the ongoing Molecular Pathology Annual symposia at University College London. The meeting gathered together a wide range of scientists and clinicians all of whom are at the cutting edge of inflammation and repair as it relates to acute lung injury. It is the breadth of approach that makes the volume so useful.

Author: Sadis Matalon
Publisher: IOS Press
ISBN: 9781586031831
Category : Lungs
Languages : en
Pages : 320

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Book Description
This book contains contributions of internationally known basic scientists and clinicians with expertise in various aspects of lung injury and repair. This monogram on the pathophysiology and treatment of Acute Lung Injury contains five different sections, each one with contributions from both basic and clinical scientists, outlining existing controversies, an how they can be resolved by future multidisciplinary studies. The various sections discuss: sodium transport and fluid clearance across the normal and injured lungs, the role of the pulmonary surfactant in the pathogenesis and treatment of ARDS, mechanisms and modification of acute and chronic lung injury, ventilatory strategies for the management of acute respiratory distress syndrome and nitric oxide: friend or foe.

Author: Robert H. Notter
Publisher: CRC Press
ISBN: 9780824757939
Category : Medical
Languages : en
Pages : 888

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Book Description
Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Author: Hector R. Wong
Publisher: Springer Science & Business Media
ISBN: 1461514274
Category : Medical
Languages : en
Pages : 329

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Book Description
Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.

Author: Michael Kasper
Publisher:
ISBN: 9783039431663
Category :
Languages : en
Pages : 222

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Book Description
Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology.

Author: Webb
Publisher: Oxford University Press
ISBN: 0198855435
Category : Medical
Languages : en
Pages : 1961

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Book Description
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Author: Ian McConachie
Publisher: Cambridge University Press
ISBN: 0521678579
Category : Medical
Languages : en
Pages : 453

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Book Description
Handbook of ICU Therapy provides rapid access to important information on the treatment of the critically ill patient. It comprises a series of 'cutting edge' reviews of the most advanced treatment concepts available in the modern ICU. Whilst assuming a basic knowledge of underlying conditions, it nonetheless outlines key physiological principles where necessary, and critically reviews current literature and best practice. The heart of the book is aimed at providing key practical information on treatment techniques to the busy clinician in an easily accessible style. In addition to conventional drug therapy, ventilator, fluid and physical therapies are also discussed in detail. All of the authors are directly involved in ICU research and practice and are familiar with all of the latest developments in this fast-moving field of medicine.