Author: Tiago Antao
Publisher: Packt Publishing Ltd
ISBN: 1789349982
Category : Computers
Languages : en
Pages : 352

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Book Description
Discover modern, next-generation sequencing libraries from Python ecosystem to analyze large amounts of biological data Key Features Perform complex bioinformatics analysis using the most important Python libraries and applications Implement next-generation sequencing, metagenomics, automating analysis, population genetics, and more Explore various statistical and machine learning techniques for bioinformatics data analysis Book Description Bioinformatics is an active research field that uses a range of simple-to-advanced computations to extract valuable information from biological data. This book covers next-generation sequencing, genomics, metagenomics, population genetics, phylogenetics, and proteomics. You'll learn modern programming techniques to analyze large amounts of biological data. With the help of real-world examples, you'll convert, analyze, and visualize datasets using various Python tools and libraries. This book will help you get a better understanding of working with a Galaxy server, which is the most widely used bioinformatics web-based pipeline system. This updated edition also includes advanced next-generation sequencing filtering techniques. You'll also explore topics such as SNP discovery using statistical approaches under high-performance computing frameworks such as Dask and Spark. By the end of this book, you'll be able to use and implement modern programming techniques and frameworks to deal with the ever-increasing deluge of bioinformatics data. What you will learn Learn how to process large next-generation sequencing (NGS) datasets Work with genomic dataset using the FASTQ, BAM, and VCF formats Learn to perform sequence comparison and phylogenetic reconstruction Perform complex analysis with protemics data Use Python to interact with Galaxy servers Use High-performance computing techniques with Dask and Spark Visualize protein dataset interactions using Cytoscape Use PCA and Decision Trees, two machine learning techniques, with biological datasets Who this book is for This book is for Data data Scientistsscientists, Bioinformatics bioinformatics analysts, researchers, and Python developers who want to address intermediate-to-advanced biological and bioinformatics problems using a recipe-based approach. Working knowledge of the Python programming language is expected.

Author: Tiago Antao
Publisher: Packt Publishing Ltd
ISBN: 180324772X
Category : Computers
Languages : en
Pages : 360

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Book Description
Discover modern, next-generation sequencing libraries from the powerful Python ecosystem to perform cutting-edge research and analyze large amounts of biological data Key Features Perform complex bioinformatics analysis using the most essential Python libraries and applications Implement next-generation sequencing, metagenomics, automating analysis, population genetics, and much more Explore various statistical and machine learning techniques for bioinformatics data analysis Book Description Bioinformatics is an active research field that uses a range of simple-to-advanced computations to extract valuable information from biological data, and this book will show you how to manage these tasks using Python. This updated third edition of the Bioinformatics with Python Cookbook begins with a quick overview of the various tools and libraries in the Python ecosystem that will help you convert, analyze, and visualize biological datasets. Next, you'll cover key techniques for next-generation sequencing, single-cell analysis, genomics, metagenomics, population genetics, phylogenetics, and proteomics with the help of real-world examples. You'll learn how to work with important pipeline systems, such as Galaxy servers and Snakemake, and understand the various modules in Python for functional and asynchronous programming. This book will also help you explore topics such as SNP discovery using statistical approaches under high-performance computing frameworks, including Dask and Spark. In addition to this, you'll explore the application of machine learning algorithms in bioinformatics. By the end of this bioinformatics Python book, you'll be equipped with the knowledge you need to implement the latest programming techniques and frameworks, empowering you to deal with bioinformatics data on every scale. What you will learn Become well-versed with data processing libraries such as NumPy, pandas, arrow, and zarr in the context of bioinformatic analysis Interact with genomic databases Solve real-world problems in the fields of population genetics, phylogenetics, and proteomics Build bioinformatics pipelines using a Galaxy server and Snakemake Work with functools and itertools for functional programming Perform parallel processing with Dask on biological data Explore principal component analysis (PCA) techniques with scikit-learn Who this book is for This book is for bioinformatics analysts, data scientists, computational biologists, researchers, and Python developers who want to address intermediate-to-advanced biological and bioinformatics problems. Working knowledge of the Python programming language is expected. Basic knowledge of biology will also be helpful.

Author: Tiago Antao
Publisher: Packt Publishing Ltd
ISBN: 1783558652
Category : Computers
Languages : en
Pages : 306

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Book Description
If you are either a computational biologist or a Python programmer, you will probably relate to the expression "explosive growth, exciting times". Python is arguably the main programming language for big data, and the deluge of data in biology, mostly from genomics and proteomics, makes bioinformatics one of the most exciting fields in data science. Using the hands-on recipes in this book, you'll be able to do practical research and analysis in computational biology with Python. We cover modern, next-generation sequencing libraries and explore real-world examples on how to handle real data. The main focus of the book is the practical application of bioinformatics, but we also cover modern programming techniques and frameworks to deal with the ever increasing deluge of bioinformatics data.

Author: Dan MacLean
Publisher: Packt Publishing Ltd
ISBN: 1789955599
Category : Science
Languages : en
Pages : 307

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Book Description
Over 60 recipes to model and handle real-life biological data using modern libraries from the R ecosystem Key FeaturesApply modern R packages to handle biological data using real-world examplesRepresent biological data with advanced visualizations suitable for research and publicationsHandle real-world problems in bioinformatics such as next-generation sequencing, metagenomics, and automating analysesBook Description Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples. This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse. By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data. What you will learnEmploy Bioconductor to determine differential expressions in RNAseq dataRun SAMtools and develop pipelines to find single nucleotide polymorphisms (SNPs) and IndelsUse ggplot to create and annotate a range of visualizationsQuery external databases with Ensembl to find functional genomics informationExecute large-scale multiple sequence alignment with DECIPHER to perform comparative genomicsUse d3.js and Plotly to create dynamic and interactive web graphicsUse k-nearest neighbors, support vector machines and random forests to find groups and classify dataWho this book is for This book is for bioinformaticians, data analysts, researchers, and R developers who want to address intermediate-to-advanced biological and bioinformatics problems by learning through a recipe-based approach. Working knowledge of R programming language and basic knowledge of bioinformatics are prerequisites.

Author: Dan MacLean
Publisher: Packt Publishing Ltd
ISBN: 1837633827
Category : Computers
Languages : en
Pages : 396

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Book Description
Discover over 80 recipes for modeling and handling real-life biological data using modern libraries from the R ecosystem Key Features Apply modern R packages to process biological data using real-world examples Represent biological data with advanced visualizations and workflows suitable for research and publications Solve real-world bioinformatics problems such as transcriptomics, genomics, and phylogenetics Purchase of the print or Kindle book includes a free PDF eBook Book DescriptionThe updated second edition of R Bioinformatics Cookbook takes a recipe-based approach to show you how to conduct practical research and analysis in computational biology with R. You’ll learn how to create a useful and modular R working environment, along with loading, cleaning, and analyzing data using the most up-to-date Bioconductor, ggplot2, and tidyverse tools. This book will walk you through the Bioconductor tools necessary for you to understand and carry out protocols in RNA-seq and ChIP-seq, phylogenetics, genomics, gene search, gene annotation, statistical analysis, and sequence analysis. As you advance, you'll find out how to use Quarto to create data-rich reports, presentations, and websites, as well as get a clear understanding of how machine learning techniques can be applied in the bioinformatics domain. The concluding chapters will help you develop proficiency in key skills, such as gene annotation analysis and functional programming in purrr and base R. Finally, you'll discover how to use the latest AI tools, including ChatGPT, to generate, edit, and understand R code and draft workflows for complex analyses. By the end of this book, you'll have gained a solid understanding of the skills and techniques needed to become a bioinformatics specialist and efficiently work with large and complex bioinformatics datasets.What you will learn Set up a working environment for bioinformatics analysis with R Import, clean, and organize bioinformatics data using tidyr Create publication-quality plots, reports, and presentations using ggplot2 and Quarto Analyze RNA-seq, ChIP-seq, genomics, and next-generation genetics with Bioconductor Search for genes and proteins by performing phylogenetics and gene annotation Apply ML techniques to bioinformatics data using mlr3 Streamline programmatic work using iterators and functional tools in the base R and purrr packages Use ChatGPT to create, annotate, and debug code and workflows Who this book is for This book is for bioinformaticians, data analysts, researchers, and R developers who want to address intermediate-to-advanced biological and bioinformatics problems by learning via a recipe-based approach. Working knowledge of the R programming language and basic knowledge of bioinformatics are prerequisites.

Author: Paurush Praveen
Publisher:
ISBN: 9781783283132
Category : Bioinformatics
Languages : en
Pages : 0

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Book Description
This book is an easy-to-follow, stepwise guide to handle real life Bioinformatics problems. Each recipe comes with a detailed explanation to the solution steps. A systematic approach, coupled with lots of illustrations, tips, and tricks will help you as a reader grasp even the trickiest of concepts without difficulty. This book is ideal for computational biologists and bioinformaticians with basic knowledge of R programming, bioinformatics and statistics. If you want to understand various critical concepts needed to develop your computational models in Bioinformatics, then this book is for you.

Author: Sebastian Bassi
Publisher: CRC Press
ISBN: 1351976958
Category : Mathematics
Languages : en
Pages : 510

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Book Description
In today's data driven biology, programming knowledge is essential in turning ideas into testable hypothesis. Based on the author’s extensive experience, Python for Bioinformatics, Second Edition helps biologists get to grips with the basics of software development. Requiring no prior knowledge of programming-related concepts, the book focuses on the easy-to-use, yet powerful, Python computer language. This new edition is updated throughout to Python 3 and is designed not just to help scientists master the basics, but to do more in less time and in a reproducible way. New developments added in this edition include NoSQL databases, the Anaconda Python distribution, graphical libraries like Bokeh, and the use of Github for collaborative development.

Author: Ken Youens-Clark
Publisher: "O'Reilly Media, Inc."
ISBN: 1098100859
Category : Computers
Languages : en
Pages : 457

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Book Description
Life scientists today urgently need training in bioinformatics skills. Too many bioinformatics programs are poorly written and barely maintained--usually by students and researchers who've never learned basic programming skills. This practical guide shows postdoc bioinformatics professionals and students how to exploit the best parts of Python to solve problems in biology while creating documented, tested, reproducible software. Ken Youens-Clark, author of Tiny Python Projects (Manning), demonstrates not only how to write effective Python code but also how to use tests to write and refactor scientific programs. You'll learn the latest Python features and toolsâ??including linters, formatters, type checkers, and testsâ??to create documented and tested programs. You'll also tackle 14 challenges in Rosalind, a problem-solving platform for learning bioinformatics and programming. Create command-line Python programs to document and validate parameters Write tests to verify refactor programs and confirm they're correct Address bioinformatics ideas using Python data structures and modules such as Biopython Create reproducible shortcuts and workflows using makefiles Parse essential bioinformatics file formats such as FASTA and FASTQ Find patterns of text using regular expressions Use higher-order functions in Python like filter(), map(), and reduce()

Author: Steven F. Lott
Publisher: Packt Publishing Ltd
ISBN: 1803236566
Category : Computers
Languages : en
Pages : 577

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Book Description
Python isn't all about object-oriented programming. Discover a valuable way of thinking about code design through a function-first approach – and learn when you need to use it. Now with detailed exercises at the end of every chapter! Purchase of the print or Kindle book includes a free eBook in PDF format. Key FeaturesLearn how, when, and why to adopt functional elements in your projectsExplore the Python modules essential to functional programming, like itertools and functoolsRevised to cover new features of Python 3.10, exercises at the end of every chapter, and moreBook Description Not enough developers understand the benefits of functional programming, or even what it is. Author Steven Lott demystifies the approach, teaching you how to improve the way you code in Python and make gains in memory use and performance. Starting from the fundamentals, this book shows you how to apply functional thinking and techniques in a range of scenarios, with examples centered around data cleaning and exploratory data analysis. You'll learn how to use generator expressions, list comprehensions, and decorators to your advantage. You don't have to abandon object-oriented design completely, though – you'll also see how Python's native object-orientation is used in conjunction with functional programming techniques. By the end of this book, you'll be well versed in the essential functional programming features of Python, and understand why and when functional thinking helps. You'll also have all the tools you need to pursue any additional functional topics that are not part of the Python language. What you will learnUse Python's libraries to avoid the complexities of state-changing classesLeverage built-in higher-order functions to avoid rewriting common algorithmsWrite generator functions to create lazy processingDesign and implement decorators for functional compositionMake use of Python type annotations to describe parameters and results of functionsApply functional programming to concurrency and web servicesExplore the PyMonad library for stateful simulationsWho this book is for The functional paradigm is very useful for programmers working in data science, but any Python developer who wants to create more reliable, succinct, and expressive code will have much to learn from this book. No prior knowledge of functional programming is required to get started, though Python programming knowledge is assumed. A running Python environment is essential.

Author: Tiago Antao
Publisher: Simon and Schuster
ISBN: 1638356866
Category : Computers
Languages : en
Pages : 302

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Book Description
Master Python techniques and libraries to reduce run times, efficiently handle huge datasets, and optimize execution for complex machine learning applications. Fast Python is a toolbox of techniques for high performance Python including: Writing efficient pure-Python code Optimizing the NumPy and pandas libraries Rewriting critical code in Cython Designing persistent data structures Tailoring code for different architectures Implementing Python GPU computing Fast Python is your guide to optimizing every part of your Python-based data analysis process, from the pure Python code you write to managing the resources of modern hardware and GPUs. You'll learn to rewrite inefficient data structures, improve underperforming code with multithreading, and simplify your datasets without sacrificing accuracy. Written for experienced practitioners, this book dives right into practical solutions for improving computation and storage efficiency. You'll experiment with fun and interesting examples such as rewriting games in Cython and implementing a MapReduce framework from scratch. Finally, you'll go deep into Python GPU computing and learn how modern hardware has rehabilitated some former antipatterns and made counterintuitive ideas the most efficient way of working. About the Technology Face it. Slow code will kill a big data project. Fast pure-Python code, optimized libraries, and fully utilized multiprocessor hardware are the price of entry for machine learning and large-scale data analysis. What you need are reliable solutions that respond faster to computing requirements while using less resources, and saving money. About the Book Fast Python is a toolbox of techniques for speeding up Python, with an emphasis on big data applications. Following the clear examples and precisely articulated details, you’ll learn how to use common libraries like NumPy and pandas in more performant ways and transform data for efficient storage and I/O. More importantly, Fast Python takes a holistic approach to performance, so you’ll see how to optimize the whole system, from code to architecture. What’s Inside Rewriting critical code in Cython Designing persistent data structures Tailoring code for different architectures Implementing Python GPU computing About the Reader For intermediate Python programmers familiar with the basics of concurrency. About the Author Tiago Antão is one of the co-authors of Biopython, a major bioinformatics package written in Python. Table of Contents: PART 1 - FOUNDATIONAL APPROACHES 1 An urgent need for efficiency in data processing 2 Extracting maximum performance from built-in features 3 Concurrency, parallelism, and asynchronous processing 4 High-performance NumPy PART 2 - HARDWARE 5 Re-implementing critical code with Cython 6 Memory hierarchy, storage, and networking PART 3 - APPLICATIONS AND LIBRARIES FOR MODERN DATA PROCESSING 7 High-performance pandas and Apache Arrow 8 Storing big data PART 4 - ADVANCED TOPICS 9 Data analysis using GPU computing 10 Analyzing big data with Dask