Brain Control of Wakefulness and Sleep PDF Download

Author: Mircea M. Steriade
Publisher: Springer Science & Business Media
ISBN: 0387262709
Category : Medical
Languages : en
Pages : 748

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Book Description
Brain Control of Wakefulness and Sleeping explores the history of efforts to understand the nature of waking and sleeping states from a biological point of view. This research represents the synthesis of the work of two individuals who have devoted their careers to investigating the mysterious states of the mind. This landmark book will interest the beginner scientist/researcher as well as the sleep clinician, with chapters on subjects including Neuronal Control of REM Sleep, Motor Systems and the Role of Active Forebrain, and Humoral Systems in Sleep Control. The authors explore the behavioral and physiological events of waking and sleep, analyzing the current realities and the future possibilities of unifying basic studies on anatomy and cellular psychology.

Author: Mircea M. Steriade
Publisher: Springer Science & Business Media
ISBN: 1475746695
Category : Medical
Languages : en
Pages : 504

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Book Description
This book is part of an ongoing history of efforts to understand the nature of waking and sleeping states from a biological point of view. We believe the recent technological revolutions in anatomy and physiology make the present moment especially propitious for this effort. In planning this book we had the choices of producing an edited volume with invited chapter authors or of writing the book ourselves. Edited volumes offer the opportunity for expression of expertise in each chapter but, we felt, would not allow the development of our ideas on the potential and actual unity of the field and would not allow the expression of coherence that can be obtained only with one or two voices, but which may be quite difficult with a chorus assembled and performing together for the first time. (Unlike musical works, there is very little precedent for rehearsals and repeated performances for authors of edited volumes or even for the existence of conductors able to induce a single rhythm and vision of the composition. ) We thus decided on a monograph. The primary goal was to communicate the current realities and the future possibilities of unifying basic studies on anatomy and cellular physiology with investigations of the behavioral and physi ological events of waking and sleep. In keeping with this goal we cross-reference the basic cellular physiology in the latter chapters, and, in the last chapter, we take up possible links to relevant clinical phenomenology.

Author: John W. Winkelman
Publisher: Cambridge University Press
ISBN: 1139494341
Category : Medical
Languages : en
Pages : 435

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Book Description
Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Author: Thien Thanh Dang-Vu
Publisher: Springer
ISBN: 9781071606582
Category : Medical
Languages : en
Pages : 277

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Book Description
The purpose of this work is to review recent findings highlighting the mechanisms and functions of the neuronal oscillations that structure brain activity across the sleep-wake cycle. An increasing number of studies conducted in humans and animals, and using a variety of techniques ranging from intracellular recording to functional neuroimaging, has provided important insight into the mechanisms and functional properties of these brain rhythms. Studies of these rhythms are fundamental not only for basic neuroscience, but also for clinical neuroscience. At the basic science level, neuronal oscillations shape the interactions between different areas of the brain and profoundly impact neural responses to the environment, thereby mediating the processing of information in the brain. At the clinical level, brain oscillations are affected in numerous neurological conditions and might provide useful biomarkers that inform about patients’ evolution and vulnerability. During sleep, these brain rhythms could provide functional support to internal states that govern the basic maintenance of local circuit and systemic interactions. During wake, the rhythmicity of cortical and subcortical circuits have been linked with sensory processing, cognitive operations, and preparation for action. This book will attempt to link together these sleep and wake functional roles at the level of neuroimaging and electroencephalographic measures, local field potentials, and even at the cellular level. ​

Author: Eric Nofzinger
Publisher: Cambridge University Press
ISBN: 1107018633
Category : Medical
Languages : en
Pages : 445

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Book Description
An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Author: M.A. Steiner
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318068446
Category : Health & Fitness
Languages : en
Pages : 165

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Book Description
The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Author: Yoshiaki Toyama
Publisher: Springer Nature
ISBN: 9811379084
Category : Medical
Languages : en
Pages : 292

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Book Description
This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Author: J. T. Enright
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 288

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Book Description
The brain functions like a computer composed of subsystems which in teract in a hierarchical manner. But it is not a single hierarchy, but a com plex system of hierarchies each of which has its very own and unique fea ture. One of these concerns the cyclic or rhythmic control of neuronal ac tivities which, among others, give rise to alternating states of wakefulness and sleep. The phenomenon of sleep still remains a mystery. The present monograph does not give us any new insights into its meaning and significance. Yet sleep research may not be the same after the appearance of this book be cause it gives us a comprehensive mathematical theory which opens our eyes to new insights into the mechanism of the rhythm generation that under lies the "wake-sleep" cycle. No one who has worked his way through this book can again look at ex perimental data without recognizing features which the "models" developed in its various chapters so strikingly reveal.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309101115
Category : Medical
Languages : en
Pages : 425

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Book Description
Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Author: Jerome Siegel
Publisher: Springer Science & Business Media
ISBN: 0387217266
Category : Medical
Languages : en
Pages : 212

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Book Description
My first contact with “the other” Jerome Siegel came in 1973, when I moved to Los Angeles to do postdoctoral work at UCLA. My thesis work had been listed in a nationally available posting without any address. The Brain Inf- mation Service, thinking they knew where I was, listed “the other” Jerome Siegel’s Delaware address for reprint requests. I soon received a letter from Jerry along with the requests he had received and we have remained in c- tact ever since. I am occasionally reminded of my namesake when I meet a new colleague who is impressed that someone “so young” published a paper in Science in 1965 (one year out of high school, if it had been me). I entered the field in the early 1970s just as he left. My interests in REM sleep and brainstem mechanisms have been eerily similar to his (and he also did po- doctoral work at UCLA), so our research contributions can be distinguished easily only by my use of my middle initial (which has occasionally been om- ted from my publications). So, my namesake and I both have an interest in seeing to it that no one “brings shame to the name. ” The current work certainly fulfills that dictum. This is a very unusual book, both in its scope and in its approach to the - terial.