Author: E. Debus
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 156
Book Description
Malaria is a disease of long duration and chronicity. Typical infections with Plas modium vivax or P. ovale last 2 to 3 years, with periodic remissions and relapses. P. malariae may persist as a latent inapparent infection up to 50 years. Even with P. Jalciparum, the most highly pathogenic species of human malaria, immunity de velops only slowly l). Under natural conditions in a holoendemic region where expo sure to reinfection is frequent and sustained, children that survive their initial infec tions show an enlarged spleen and are likely to continue to show parasites until puber ty, or even beyond. In such a region adults do not have a markedly enlarged spleen, rarely show parasites and are rarely ill with malaria. This acquired immunity is effec tive mainly against the local strains of falciparum malaria and fades rapidly if the individual lives for some months in a non-malarious region. Nevertheless, if such an immunity could be induced earlier by vaccination, and especially if it could be induced in young children, many lives would be saved and much illness prevented. An effective vaccine would also serve as an additional tool which, combined with mosquito control measures and appropriate chemotherapy, might greatly reduce the incidence of malaria. Clearly a vaccine could also be useful for the protection of short term visitors to malarious regions. Such protection is becoming increasingly difficult to provide as drugresistant strains of P. Jalciparum continue to spread 2).
Control of Immune Response by Endocrine Factors ; Malaria Vaccine ; Controlled Drug Delivery ; Enzyme-immunoassay
Author: E. Debus
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 156
Book Description
Malaria is a disease of long duration and chronicity. Typical infections with Plas modium vivax or P. ovale last 2 to 3 years, with periodic remissions and relapses. P. malariae may persist as a latent inapparent infection up to 50 years. Even with P. Jalciparum, the most highly pathogenic species of human malaria, immunity de velops only slowly l). Under natural conditions in a holoendemic region where expo sure to reinfection is frequent and sustained, children that survive their initial infec tions show an enlarged spleen and are likely to continue to show parasites until puber ty, or even beyond. In such a region adults do not have a markedly enlarged spleen, rarely show parasites and are rarely ill with malaria. This acquired immunity is effec tive mainly against the local strains of falciparum malaria and fades rapidly if the individual lives for some months in a non-malarious region. Nevertheless, if such an immunity could be induced earlier by vaccination, and especially if it could be induced in young children, many lives would be saved and much illness prevented. An effective vaccine would also serve as an additional tool which, combined with mosquito control measures and appropriate chemotherapy, might greatly reduce the incidence of malaria. Clearly a vaccine could also be useful for the protection of short term visitors to malarious regions. Such protection is becoming increasingly difficult to provide as drugresistant strains of P. Jalciparum continue to spread 2).
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 156
Book Description
Malaria is a disease of long duration and chronicity. Typical infections with Plas modium vivax or P. ovale last 2 to 3 years, with periodic remissions and relapses. P. malariae may persist as a latent inapparent infection up to 50 years. Even with P. Jalciparum, the most highly pathogenic species of human malaria, immunity de velops only slowly l). Under natural conditions in a holoendemic region where expo sure to reinfection is frequent and sustained, children that survive their initial infec tions show an enlarged spleen and are likely to continue to show parasites until puber ty, or even beyond. In such a region adults do not have a markedly enlarged spleen, rarely show parasites and are rarely ill with malaria. This acquired immunity is effec tive mainly against the local strains of falciparum malaria and fades rapidly if the individual lives for some months in a non-malarious region. Nevertheless, if such an immunity could be induced earlier by vaccination, and especially if it could be induced in young children, many lives would be saved and much illness prevented. An effective vaccine would also serve as an additional tool which, combined with mosquito control measures and appropriate chemotherapy, might greatly reduce the incidence of malaria. Clearly a vaccine could also be useful for the protection of short term visitors to malarious regions. Such protection is becoming increasingly difficult to provide as drugresistant strains of P. Jalciparum continue to spread 2).
Control of Immune Response by Endocrine Factors Malaria Vaccine Controlled Drug Delivery Enzyme-Immunoassay
Author: E Debus
Publisher:
ISBN: 9783642715037
Category :
Languages : en
Pages : 154
Book Description
Publisher:
ISBN: 9783642715037
Category :
Languages : en
Pages : 154
Book Description
Control of immune response by endocrine factors ; Malaria vaccine ; controlled drug delivery ; enzyme-immunoassay
Author: E. Debus
Publisher:
ISBN: 9783055003790
Category :
Languages : en
Pages : 146
Book Description
Publisher:
ISBN: 9783055003790
Category :
Languages : en
Pages : 146
Book Description
The Emergence of Drugs which Block Calcium Entry
Author: Ronald D. Smith
Publisher: Springer Science & Business Media
ISBN: 3642732283
Category : Medical
Languages : en
Pages : 163
Book Description
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
Publisher: Springer Science & Business Media
ISBN: 3642732283
Category : Medical
Languages : en
Pages : 163
Book Description
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
Steroids and their Medicinal Potential
Author: Abid Hussain Banday
Publisher: Bentham Science Publishers
ISBN: 9815049348
Category : Science
Languages : en
Pages : 330
Book Description
Steroids are an important class of biomolecules with diverse roles and functions. Besides being important as structural and signaling molecules, these molecules hold promise against numerous disorders, including cardiovascular conditions, cancer, inflammation, and autoimmune disorders. Many investigations have demonstrated that steroidal frameworks may provide lipid solubility, receptor selectivity, or membrane binding properties to non-steroidal pharmacophores. However, the therapeutic use of steroids can be dangerous when they're used incorrectly. Additionally, misconceptions about steroids among athletes or recreational users can lead to steroid abuse and poor health outcomes. Steroids and their MedicinalPotential discusses the classification, distribution, biosynthesis, chemical synthesis, and semi-synthesis of different steroids. The medicinal potential of each class is exhaustively discussed in different chapters. The latest advances and developments in steroid-based drug discovery are also discussed thoroughly. The book aims to address general questions and concerns about steroids, providing readers with a useful resource on the subject. Key Features -Provides comprehensive coverage on all aspects of steroids including steroid chemistry, biochemistry, medicinal potential, drug discovery, and advances in target-binding interactions of steroid-based drugs -Includes chapters dedicated to anabolic steroids and their abuse -Designed as an accessible source of information for understanding steroidal drugs with structured chapters-Includes references for advanced readers.
Publisher: Bentham Science Publishers
ISBN: 9815049348
Category : Science
Languages : en
Pages : 330
Book Description
Steroids are an important class of biomolecules with diverse roles and functions. Besides being important as structural and signaling molecules, these molecules hold promise against numerous disorders, including cardiovascular conditions, cancer, inflammation, and autoimmune disorders. Many investigations have demonstrated that steroidal frameworks may provide lipid solubility, receptor selectivity, or membrane binding properties to non-steroidal pharmacophores. However, the therapeutic use of steroids can be dangerous when they're used incorrectly. Additionally, misconceptions about steroids among athletes or recreational users can lead to steroid abuse and poor health outcomes. Steroids and their MedicinalPotential discusses the classification, distribution, biosynthesis, chemical synthesis, and semi-synthesis of different steroids. The medicinal potential of each class is exhaustively discussed in different chapters. The latest advances and developments in steroid-based drug discovery are also discussed thoroughly. The book aims to address general questions and concerns about steroids, providing readers with a useful resource on the subject. Key Features -Provides comprehensive coverage on all aspects of steroids including steroid chemistry, biochemistry, medicinal potential, drug discovery, and advances in target-binding interactions of steroid-based drugs -Includes chapters dedicated to anabolic steroids and their abuse -Designed as an accessible source of information for understanding steroidal drugs with structured chapters-Includes references for advanced readers.
Current Catalog
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712
Book Description
First multi-year cumulation covers six years: 1965-70.
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712
Book Description
First multi-year cumulation covers six years: 1965-70.
National Library of Medicine Current Catalog
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 420
Book Description
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 420
Book Description
Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators
Author:
Publisher: Springer Science & Business Media
ISBN: 3642734618
Category : Medical
Languages : en
Pages : 153
Book Description
Das Buch enthlt Kapitel ber: M.B. Bottorff, W.E. Evans, Memphis, TN, USA: berwachung der Medikament-KonzentrationE. Truscheit, I. Hillebrand, B. Junge, L. Mller, W. Puls, D.D. Schmidt, Wuppertal, FRG: Inhibitoren der mikrobiellen alpha-Glucosidase: Chemie, Biochemie und potentielle therapeutische AnwendungenH. Will, Berlin-Buch, GDR: Plasminogen-Aktivatoren: Molekleigenschaften, biologische Zellfunktion und klinische Anwendung.
Publisher: Springer Science & Business Media
ISBN: 3642734618
Category : Medical
Languages : en
Pages : 153
Book Description
Das Buch enthlt Kapitel ber: M.B. Bottorff, W.E. Evans, Memphis, TN, USA: berwachung der Medikament-KonzentrationE. Truscheit, I. Hillebrand, B. Junge, L. Mller, W. Puls, D.D. Schmidt, Wuppertal, FRG: Inhibitoren der mikrobiellen alpha-Glucosidase: Chemie, Biochemie und potentielle therapeutische AnwendungenH. Will, Berlin-Buch, GDR: Plasminogen-Aktivatoren: Molekleigenschaften, biologische Zellfunktion und klinische Anwendung.
International Books in Print
Vaccines
Author: Ciro A. de Quadros
Publisher: Pan American Health Org
ISBN: 9275115966
Category : Medical
Languages : en
Pages : 410
Book Description
This publication contains a number of papers which consider the public health role of vaccines in improving the health of the world's populations, and looks at the challenges of using immunisation to combat emerging and re-emerging diseases. Issues discussed include the innovative use of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis, efforts to develop a new generation of vaccines against cholera and typhoid, shigella and Helicobacter pylori, as well as developments in the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. It also deals with the use of vaccines to fight bioterrorism attacks; regulatory and safety issues; financing issues, impact of health sector reform and the sustainability of immunisation programmes.
Publisher: Pan American Health Org
ISBN: 9275115966
Category : Medical
Languages : en
Pages : 410
Book Description
This publication contains a number of papers which consider the public health role of vaccines in improving the health of the world's populations, and looks at the challenges of using immunisation to combat emerging and re-emerging diseases. Issues discussed include the innovative use of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis, efforts to develop a new generation of vaccines against cholera and typhoid, shigella and Helicobacter pylori, as well as developments in the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. It also deals with the use of vaccines to fight bioterrorism attacks; regulatory and safety issues; financing issues, impact of health sector reform and the sustainability of immunisation programmes.