Genetics and Precision Medicine,An issue of Medical Clinics of North America PDF Download

Author: Howard P. Levy
Publisher: Elsevier Health Sciences
ISBN: 0323696260
Category : Medical
Languages : en
Pages :

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Book Description
This issue of Medical Clinics of North America, guest edited by Dr. Howard P. Levy, is devoted to Genetics and Precision Medicine. Articles in this important issue include: Family History in Genetics and Precision Medicine; Genetic Testing: Who, What, When and Why; Test Result Disclosure and When to Consult a Geneticist or Genetic Counselor; Patient Engagement to Inform a Large-scale Population Sequencing Program; Pharmacogenetics: Prescribing Precisely; DNA Testing for Early Cancer Diagnosis; Breast Cancer: BRCA and Beyond; Colon Cancer and Other GI Cancers; Neurofibromatosis and Related Disorders; Marfan, Loeys Dietz, and Other Syndromes Causing Arterial Fragility; Ehlers Danlos Syndromes and Related Disorders of Connective Tissue; Parkinson, Alzheimer, and Other Neuropsychiatric Diseases; Genetic Neurologic and Neuromuscular Disorders; and Polycystic Kidney Disease and Other Genetic Kidney Disorders. A CME program is also available for this title.

Author: Geoffrey S. Ginsburg
Publisher: Academic Press
ISBN: 0128006544
Category : Science
Languages : en
Pages : 370

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Book Description
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309462630
Category : Medical
Languages : en
Pages : 145

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Book Description
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Author: Ryan J. Schmidt
Publisher: Elsevier Health Sciences
ISBN: 0323758460
Category : Medical
Languages : en
Pages : 129

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Book Description
This issue of Clinics in Laboratory Medicine will cover Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies. Curated by Dr. Ryan J. Schmidt, this issue is one of four selected each year by the series Consulting Editor, Milenko Tanasijevic. The volume will include articles on: Features of a Comprehensive Precision Medicine Program for Constitutional Genetic Disorders, Establishing a Precision Medicine Center of Excellence for Rare Disease, High-throughput DNA Sequencing for Rare Disease Diagnosis, Enhancing Diagnosis through RNA Sequencing, Interpretation of Rare Genetic Variants, Clinical Bioinformatics, Precision Therapies for Retinal Dystrophy, Precision Therapies for Muscular Dystrophy, Therapeutic Gene Editing, High Throughput Functional Studies of Genetic Variants, and Patient-specific Disease Models.

Author: Antonie D. Kline
Publisher: Academic Press
ISBN: 0128164794
Category : Medical
Languages : en
Pages : 622

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Book Description
Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling illustrates the current scope of the practice of genetics for healthcare professionals, so they can understand principles applicable to genetic testing and consultation. Written by an authoritative well-balanced team, including experienced clinical geneticists, genetic counselors, and medical subspecialists, this book adopts an accessible, easy-to-follow format. Sections are dedicated to basic genetic principles; clinical genetic and genomic testing; prenatal, clinical and cancer genetic diagnosis and counseling; and ethical and social implications in genomic medicine. Over 100 illustrative cases examine a range of prenatal, pediatric and adult genetic conditions and testing, putting these concepts and approaches into practice. Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling is important for primary care providers, as patient care evolves in the current genomic-influenced world of precision medicine. Clearly explains central concepts of genetic testing and genomic medicine for non-genetic physicians, healthcare providers, and trainees Offers clear steps for clinical integration of genetic concepts, genomic technology, and interpretation of genetic test results approachable and relevant to clinical practice Descriptive, applied case studies illustrate recommended genetic evaluation, counseling and management for a range of conditions throughout the lifetime

Author: Mariza de Andrade
Publisher: Frontiers Media SA
ISBN: 2889198723
Category : Electronic book
Languages : en
Pages : 196

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Book Description
This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.

Author: Stephen D. Krau
Publisher: Elsevier Health Sciences
ISBN: 0323261116
Category : Medical
Languages : en
Pages : 188

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Book Description
This issue of Nursing Clinics of North America is Guest Edited by Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University and will focus on genomics. Article topics will include Genetic and Genomic Testing, Integrating Genomics into Research, Genomic Assessments and Interventions in Psychiatric Nursing Practice, Genomics in Critical Care, Cardiomyopathy and Genetics, Genetics and Chronic Diseases, Genomics and Patients with Rare Chronic Diseases, Epigenetics and the implications for disease processes, Impact of Genetics on Oncology Nursing, and Pharmacogenetics.

Author: Ryan J. Schmidt
Publisher: Elsevier
ISBN: 9780323758451
Category : Medical
Languages : en
Pages : 240

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Book Description
This issue of Clinics in Laboratory Medicine will cover Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies. Curated by Dr. Ryan J. Schmidt, this issue is one of four selected each year by the series Consulting Editor, Milenko Tanasijevic. The volume will include articles on: Features of a Comprehensive Precision Medicine Program for Constitutional Genetic Disorders, Establishing a Precision Medicine Center of Excellence for Rare Disease, High-throughput DNA Sequencing for Rare Disease Diagnosis, Enhancing Diagnosis through RNA Sequencing, Interpretation of Rare Genetic Variants, Clinical Bioinformatics, Precision Therapies for Retinal Dystrophy, Precision Therapies for Muscular Dystrophy, Therapeutic Gene Editing, High Throughput Functional Studies of Genetic Variants, and Patient-specific Disease Models.

Author: Carrie Finno
Publisher: Elsevier Health Sciences
ISBN: 0323708609
Category : Medical
Languages : en
Pages : 273

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Book Description
This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Carrie Finno, focuses on Equine Genetic Diseases. Topics include: Genetics, Genomics, and Emergent Precision Medicine 12 years post Equine Reference Genome; Equine SNP Genotyping Arrays; Next-generation Sequencing; Genetic Testing in the Horse; Genetics of Cardiovascular Disease; Genetics of Respiratory Disease; Genetics of Neurological Disease; Genetics of Immune Disease; Genetics of Orthopedic Disease; Genetics of Ocular Disease; Genetics of Skin Disease; Genetics of Endocrine and Metabolic Disease; Genetics of Muscle Disease; Genetics of Laminitis; Genetics of Reproductive Diseases; and Genetics of Behavioral Traits.

Author: Judy S. Crabtree
Publisher: Academic Press
ISBN: 0128204028
Category : Medical
Languages : en
Pages : 114

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Book Description
Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource