Molecular Genetics of Endometrial Carcinoma PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Molecular Genetics of Endometrial Carcinoma PDF full book. Access full book title Molecular Genetics of Endometrial Carcinoma by Lora Hedrick Ellenson. Download full books in PDF and EPUB format.
Author: Lora Hedrick Ellenson Publisher: Springer ISBN: 3319431390 Category : Medical Languages : en Pages : 281
Book Description
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author: Lora Hedrick Ellenson Publisher: Springer ISBN: 3319431390 Category : Medical Languages : en Pages : 281
Book Description
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author: Michael T. Deavers Publisher: Springer ISBN: 3319579851 Category : Medical Languages : en Pages : 286
Book Description
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Author: Mansoor R. Mirza Publisher: Springer ISBN: 3319645137 Category : Medical Languages : en Pages : 324
Book Description
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
Author: Garden Grove Garden Grove Press Publisher: ISBN: 9781544932149 Category : Languages : en Pages : 168
Book Description
This article collection reviews the medical genetics of endometrial cancer and includes 20 papers by various authors. Topics include: Genetic variants in MUTYH are not associated with endometrial cancer risk; Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium; Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families; Genetic testing in a gynaecological oncology care in developing countries - knowledge, attitudes and perception of Nepalese clinicians; New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care; PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study; Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk; Genetic variations of MUC17 are associated with endometriosis development and related infertility; Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma; Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer; Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach; Potential contribution of the uterine microbiome in the development of endometrial cancer; The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor; Common mitochondrial polymorphisms as risk factor for endometrial cancer; Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma; Immunotherapy in endometrial cancer - an evolving therapeutic paradigm; HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study; Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome; Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report; The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author: Franco Muggia Publisher: Springer Science & Business Media ISBN: 1603270442 Category : Medical Languages : en Pages : 302
Book Description
For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.
Author: S.J. Kitson Publisher: Karger Medical and Scientific Publishers ISBN: 3318072427 Category : Medical Languages : en Pages : 118
Book Description
Endometrial cancer (EC) is the most common cancer of the uterus and the only gynecologic malignancy that is increasing in incidence and mortality. Early-stage EC generally has a good prognosis but 5-year survival is poor for those with advanced-stage disease or recurrent disease. This resource provides the latest information on epidemiology, risk factors and diagnosis, including the implications of Lynch syndrome in younger women, and the latest thinking on classification, grading, staging and prognostic risk groups, made possible by major advances in the molecular characterization of EC. The therapeutic implications of these advances are still being discovered and here we outline the latest evidence-based therapies and management of the disease. Table of Contents: • Epidemiology and risk factors • Diagnosis • Grading, staging and prognosis • Molecular characterization • Treatment of early-stage disease • Management of advanced and recurrent disease • Research directions
Author: Robert F. Ozols Publisher: Taylor & Francis ISBN: 9780792380702 Category : Medical Languages : en Pages : 408
Book Description
Text focusing primarily on ovarian cancer. Explores advances in cytoreductive surgery, problems in screening, new drugs, chemotherapy, hereditary basis for gynecologic malignancies, molecular genetics, molecular biology, and new biologic therapies. For researchers and pathologists, surgeons, chemotherapists, and practitioners.
Author: Ulrich Pfeffer Publisher: Springer Science & Business Media ISBN: 9400758421 Category : Medical Languages : en Pages : 591
Book Description
The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
Author: Fiona Macdonald Publisher: Taylor & Francis ISBN: 1135321590 Category : Science Languages : en Pages : 333
Book Description
Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.
Author: Lora Hedrick Ellenson
Author: Lora Hedrick Ellenson
Author: Michael T. Deavers
Author: Mansoor R. Mirza
Author: Ahmad Hamta
Author: Garden Grove Garden Grove Press
Author: Franco Muggia
Author: S.J. Kitson
Author: Robert F. Ozols
Author: Ulrich Pfeffer
Author: Fiona Macdonald