Molecular and Cellular Therapies for Motor Neuron Diseases PDF Download

Author: Nicholas M Boulis
Publisher: Academic Press
ISBN: 0128025247
Category : Psychology
Languages : en
Pages : 336

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Book Description
Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Author: P.N. Leigh
Publisher: Springer Science & Business Media
ISBN: 1447118715
Category : Medical
Languages : en
Pages : 477

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Book Description
Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.

Author: Kevin Talbot
Publisher: Oxford University Press
ISBN: 019954736X
Category : Medical
Languages : en
Pages : 228

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Book Description
Written and designed to provide comprehensive, easily accessible advice for all healthcare professionals involved in the care of patients with this challenging condition, this book addresses the entire care pathway from presentation to diagnosis to symptom management and end of life issues.

Author: Mark B. Bromberg
Publisher: Contemporary Neurology
ISBN: 019978311X
Category : Medical
Languages : en
Pages : 369

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Book Description
'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.

Author: David Oliver
Publisher: Oxford University Press, USA
ISBN: 0199686025
Category : Medical
Languages : en
Pages : 337

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Book Description
This volume provides an evidence-based guide to the care of people with ALS/MND, including the control of symptoms, the psychosocial care of patients and their families, and care in bereavement.

Author: Oscar Alzate
Publisher: CRC Press
ISBN: 9781420076264
Category : Science
Languages : en
Pages : 354

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Book Description
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable. Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive. Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s. Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises. New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance our understanding of the brain and show us ways to abate the suffering caused by neurological and mental diseases.

Author: Arash Salardini
Publisher: McGraw Hill Professional
ISBN: 0071845828
Category : Medical
Languages : en
Pages : 982

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Book Description
A practical, protocol-oriented guide to the practice of neurology in the hospital setting A Doody's Core Title for 2019! Hospital neurology is one of the fastest growing subspecialties within neurology. Running an efficient and effective neurohospitalist line is important to the financial success of hospitals and the physicians employed there. Many neurology patients also have internal medicine problems, and often it is a general hospitalist without neurology training who treat these patients. These physicians sorely need more information on neurology. Conversely, neurologists caring for these patients have only had one year of internal medicine training and require more guidance on medical problems. Given these realities, there is a need for a resource on hospital neurology. With The Hospital Neurology Book, Drs. Salardini and Biller have created a practical, concise, and useful work that guides both neurologists and internists in the areas in which their training is currently not sufficient for hospital practice. The Hospital Neurology Book features a highly readable format, providing information physicians can act upon, including recipes and protocols for patient care and question-based chapter headings that lead physicians to the exact issue they are dealing with in the moment. Each chapter (or chapter section as appropriate) opens with a case study, setting the stage in a highly practical manner, and ends with high yield summary points useful for consolidating learning.

Author: Eva L. Feldman
Publisher: Springer
ISBN: 3709116058
Category : Medical
Languages : en
Pages : 320

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Book Description
This atlas presents a comprehensive outline of neuromuscular diseases, written by respected American and European authors. It discusses all aspects of neuromuscular disorders including cranial and spinal nerves, motor neuron diseases, nerve plexus, peripheral nerves, mono- and polyneuropathies, entrapment syndromes, neuromuscular junctions, and muscle disease. Each chapter is structured into the following sections: anatomy, symptoms, signs, pathogenesis, diagnosis and differential diagnosis, therapy and prognosis. The diagnostic tools in neuromuscular disease are explained and practical guidelines are offered on how to advance from symptoms to syndromes. The therapeutic options for each disease are also described. In this new edition, the structure of the chapters has been reorganized and chapters on principles of peripheral nerves, nerve pain, nerve surgery and rehabilitation have been added. The current trend of increased use of imaging techniques such as US and MRI in the diagnosis and follow-up of neuromuscular disorders is also reflected.

Author: Thomas T. Warner
Publisher: Elsevier Health Sciences
ISBN: 0702038458
Category : Medical
Languages : en
Pages : 343

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Book Description
This simple guide to neurogenetics demystifies the overwhelming amount of information on the subject so you can identify key clinical features and understand your management options. Reach relevant differential diagnoses and provide appropriate counseling to your patients using the symptom-based approach. By integrating genetic and neurological approaches to diagnoses, this book ensures that the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis are clear and explicit. Concise and portable, this book is ideal for easy reference in clinical use. Details the underlying basic science and clinical features of genetic disorders by taking a symptom-based approach to provide you with a comprehensive understanding of the field. Focuses on the clinical application of neurogenetics to be of practical use to you in the clinic. Clarifies the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis by integrating genetic and neurological approaches to diagnoses. Discusses and evaluates necessary investigations so you know when to use them and when to refer. Highlights diagnostic and therapeutic tips so you can learn new concepts or refine your skills in practice. Refers to online sources, such as Online Mendelian Inheritance in Man (OMIM) and others, to help you supplement your knowledge.

Author: Peter Scott-Morgan
Publisher: Penguin UK
ISBN: 0241447119
Category : Biography & Autobiography
Languages : en
Pages : 320

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Book Description
The incredible book behind the primetime Channel 4 documentary, Peter: The Human Cyborg 'A remarkable account of what it means to be human and what technology can really achieve' Sunday Telegraph 'Peter's story is one of the most extraordinary you will ever hear. I urge people to read it' Stephen Fry 'A remarkable story . . . you're left desperate to take nothing for granted' Radio Times __________ Peter, a brilliant scientist, is told that he will lose everything he loves. His husband. His family. His friends. His ability to travel the world. All will be gone. But Peter will not give up. He vows that this will not be the end and instead seeks a completely new beginning . . . Peter has Motor Neurone Disease, a condition universally considered by doctors to be terminal. He is told it will destroy his nerve cells and that within about two years, it will take his life too. But, face-to-face with death, he decides there is another way. Using his background in science and technology, he navigates a new path, one that will enable him not just to survive, but to thrive. This is the astonishing true story about Peter Scott-Morgan: the first person to combine his very humanity with artificial intelligence and robotics to become a full Cyborg. His discovery means that his terminal diagnosis is negotiable, something that will rewrite the future. And change the world. By embracing love, life and hope rather than fear, tragedy and despair, he will become Peter 2.0. __________ 'Compelling . . . Scott-Morgan is a true one-off. It is in the telling of the love story, rather than the technical details of becoming a cyborg, that this book succeeds' The Times 'What's striking is Peter's constant optimism, bravery and his ability to find radical answers to problems that have confounded Britain's brightest minds' Daily Telegraph 'A soaring love story' Financial Times 'Fascinating and extremely moving' Sun