OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment PDF Download

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078444
Category :
Languages : en
Pages : 115

Book Description
This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078444
Category :
Languages : en
Pages : 115

Book Description
This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.

OECD Guidelines for Testing of Chemicals

OECD Guidelines for Testing of Chemicals PDF Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :

Book Description

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078444
Category :
Languages : en
Pages : 116

Book Description
This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work as well as guidance to the interpretation of data for use in applying the classification criteria.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264070583
Category :
Languages : en
Pages : 7

Book Description
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 405: Acute Eye Irritation/Corrosion

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 405: Acute Eye Irritation/Corrosion PDF Author: OECD
Publisher: OECD Publishing
ISBN: 926418533X
Category :
Languages : en
Pages : 13

Book Description
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...

Mixture Toxicity

Mixture Toxicity PDF Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 9781439830093
Category : Medical
Languages : en
Pages : 320

Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address: Exposure — how to quantify the amounts of chemicals that may enter the living organism Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time Toxicity — what are the chemicals’ detrimental effects on the organism Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals Risk assessment — how to assess for risks in humans and the environment An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Report of the OECD/UNEP Workshop on the Use of Multimedia Models for Estimating Overall Environmental Persistence and Long Range Transport in the Context of PBTS/POPS Assessment

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Report of the OECD/UNEP Workshop on the Use of Multimedia Models for Estimating Overall Environmental Persistence and Long Range Transport in the Context of PBTS/POPS Assessment PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078509
Category :
Languages : en
Pages : 191

Book Description
This document contains the report from the OECD/UNEP Workshop on the Use of Multimedia Models for Estimating Overall Persistence and Long-range Transport in the Context of PBTs/POPs Assessment, held on 29-31 October 2001 in Ottawa, Canada, together ...

A Framework to Guide Selection of Chemical Alternatives

A Framework to Guide Selection of Chemical Alternatives PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309310164
Category : Science
Languages : en
Pages : 280

Book Description
Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078495
Category :
Languages : en
Pages : 112

Book Description
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078479
Category :
Languages : en
Pages : 249

Book Description
This document sets out the objectives, organisational context, and plan for a Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures.
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