Stereology and Morphometry in Pathology PDF Download

Author: Yrjö Collan
Publisher:
ISBN:
Category : Biometry
Languages : en
Pages : 298

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Author: U. N. Riede
Publisher:
ISBN: 9783437106514
Category : Electron microscopy
Languages : en
Pages : 404

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Author: A Reith
Publisher: CRC Press
ISBN:
Category : Medical
Languages : en
Pages : 248

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Author: J.P. Baak
Publisher: Springer Science & Business Media
ISBN: 3642748236
Category : Medical
Languages : en
Pages : 208

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Book Description
J. Oort and J.P.A. Baak This manual is written by pathologists and is meant for pathologists. It deals with a subject that became especially popular in pathology at the end of the last decade: morphometry. Morphometry is defined as the quantitative description of a structure (Weibel, 1969). This structure may be both of macroscopic and micro scopic size. Strictly, the size of an organ is a morphometric feature. This type of morphometry has long been in use in pathology. Examples ofthis type in diagnostic pathology have been given by Roesle and Roulet (1932). In this manual, however, the term morphometry is used in its re stricted microscopic meaning, i.e., the quantitative description of micro scopic images and features. The quantitative analysis of microscopic pic tures has for a long time been subordinated to the qualitative description. This may partly have been caused by the preference of the human mirld for pattern recognition rather than quantitative appraisal, which leads to judgements based on impressions subconsciously tested against the ob server's (mental) image of the normal pattern. Another cause may have been the time-consuming difficulties of collecting and computing quanti tative information. During the past decades the usefulness of quantitative methods in histo- and cytopathology has been stressed for many different subjects. In addition, minicomputers have become widely available and are becoming increasingly inexpensive; the more so since the introduction of micro com puters.

Author: George A. Parker
Publisher: Springer
ISBN: 3319473778
Category : Medical
Languages : en
Pages : 670

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Book Description
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Author: Terry M. Mayhew
Publisher:
ISBN:
Category : Stereology
Languages : en
Pages : 215

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Book Description

Author: Vyvyan Howard
Publisher: Garland Science
ISBN: 0203006399
Category : Medical
Languages : en
Pages : 277

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Book Description
Unbiased Stereology, Second Edition is a practical guide to making unbiased 3-D measurements via the microscope. Only those stereological techniques which have been tried and tested by real application are included. Although this technology is essentially mathematical and statistical, the authors do not immerse the reader in complex analysis, but rather provide simple heuristic explanations and references to the original proof, and illustrate the theory by analogies drawn from everyday experience. To give practical experience in application of the techniques, exercises are provided at the end of each chapter, complete with detailed worked answers.

Author: Jan P. A. Baak
Publisher: Springer
ISBN: 9783540114314
Category : Anthropometry
Languages : en
Pages : 205

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Author: William A. Aherne
Publisher: Hodder Arnold
ISBN: 9780713145380
Category : Medical
Languages : en
Pages : 205

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Book Description

Author: Stephen M. Evans
Publisher:
ISBN: 9780198505280
Category : Medical
Languages : en
Pages : 362

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Book Description
Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlatingstructural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology isto be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitativemethods, such as those offered by stereology. Quantitative Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae.Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.