Author: Ioannis D. Kostas Publisher: MDPI ISBN: 3038425567 Category : Electronic book Languages : en Pages : 273
Book Description
This book is a printed edition of the Special Issue "Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications" that was published in Catalysts
Author: David C. Blakemore Publisher: Royal Society of Chemistry ISBN: 1849738033 Category : Drug development Languages : en Pages : 474
Book Description
The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
Author: Anant R. Kapdi Publisher: Elsevier ISBN: 012811293X Category : Science Languages : en Pages : 358
Book Description
Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Author: Norio Miyaura Publisher: Springer ISBN: 354045313X Category : Science Languages : en Pages : 248
Book Description
In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).
Author: Publisher: Academic Press ISBN: 0128171820 Category : Science Languages : en Pages : 587
Book Description
Advances in Heterocyclic Chemistry, Volume 128, is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this updated volume includes sections on Recent Advances in 1,2,4-Triazolo-[1,5-a]pyrimidine Chemistry, Fluorescent Heterocycles: Recent Trends and New Developments, and Reactions of 3-Pyrrolin-2-ones. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews as written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance our understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds
Author: Yasushi Nishihara Publisher: Springer Science & Business Media ISBN: 3642323685 Category : Science Languages : en Pages : 245
Book Description
“Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Author: Takayuki Shioiri Publisher: John Wiley & Sons ISBN: 3527633693 Category : Technology & Engineering Languages : en Pages : 544
Book Description
Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients.
Author: Ivica Cepanec Publisher: Elsevier ISBN: 0080474535 Category : Science Languages : en Pages : 364
Book Description
Organic chemistry is one of the most rapidly growing sciences. There is a wide variety of applications of organic compounds, for instance, pharmaceutically active substances, agrochemicals, optoelectronics, etc. Within this group there are hundereds and thousands of new compounds synthesized or isolated from natural sources. Such important organic chemistry developments are accompanied by the profound break-through of new reactions, increasingly efficient methodologies, reagents and catalysts. The chemistry of biaryls is one of the most interesting fields in organic chemistry, this book looks at these reactions both new and old. Synthesis of Biaryls presents the description of a given method for the synthesis of biaryls: short introduction, reaction mechanism, application, representative synthetic procedures, conclusion and literature references. This book will be of interest to organic chemists in industry and academia. A topic of growing importance in organic synthesis The FIRST book to cover all reactions for the synthesis of biaryls, including the most recent The book provides detailed applications of each method described
Author: José Pérez Sestelo Publisher: MDPI ISBN: 3039435671 Category : Science Languages : en Pages : 234
Book Description
In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.
Author: Ioannis D. Kostas
Author: Ioannis D. Kostas (Ed.)
Author: David C. Blakemore
Author: Anant R. Kapdi
Author: Norio Miyaura
Author: 
Author: Yasushi Nishihara
Author: Takayuki Shioiri
Author: Ivica Cepanec
Author: José Pérez Sestelo