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Author: John Parrington Publisher: Oxford University Press ISBN: 0192552465 Category : Science Languages : en Pages : 368
Book Description
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.
Author: John Parrington Publisher: Oxford University Press ISBN: 0192552465 Category : Science Languages : en Pages : 368
Book Description
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.
Author: Spencer Wells Publisher: National Geographic Books ISBN: 9781426201189 Category : Science Languages : en Pages : 260
Book Description
A scientist and explorer describes his ambitious genetic research project to map the ancient roots and mystery of human origins, explaining how an individual's DNA can provide a key piece to the puzzle of human history.
Author: Moyra Smith Publisher: FT Press ISBN: 0132172844 Category : Medical Languages : en Pages : 243
Book Description
Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.
Author: Lone Frank Publisher: Simon and Schuster ISBN: 1851688641 Category : Biography & Autobiography Languages : en Pages : 320
Book Description
Internationally acclaimed science writer Lone Frank swabs up her DNA to provide the first truly intimate account of the new science of consumer-led genomics. She challenges the business mavericks intent on mapping every baby's genome, ponders the consequences of biological fortune-telling, and prods the psychologists who hope to uncover just how much or how little our environment will matter in the new genetic century - a quest made all the more gripping as Frank considers her family's and her own struggles with depression.
Author: John Parrington Publisher: Oxford University Press ISBN: 0198813090 Category : Medical Languages : en Pages : 369
Book Description
As the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way ... but the emerging picture is if anything far more exciting. Parrington gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species.
Author: Elise K. Burton Publisher: Stanford University Press ISBN: 1503614573 Category : History Languages : en Pages : 464
Book Description
The Middle East plays a major role in the history of genetic science. Early in the twentieth century, technological breakthroughs in human genetics coincided with the birth of modern Middle Eastern nation-states, who proclaimed that the region's ancient history—as a cradle of civilizations and crossroads of humankind—was preserved in the bones and blood of their citizens. Using letters and publications from the 1920s to the present, Elise K. Burton follows the field expeditions and hospital surveys that scrutinized the bodies of tribal nomads and religious minorities. These studies, geneticists claim, not only detect the living descendants of biblical civilizations but also reveal the deeper past of human evolution. Genetic Crossroads is an unprecedented history of human genetics in the Middle East, from its roots in colonial anthropology and medicine to recent genome sequencing projects. It illuminates how scientists from Turkey to Yemen, Egypt to Iran, transformed genetic data into territorial claims and national origin myths. Burton shows why such nationalist appropriations of genetics are not local or temporary aberrations, but rather the enduring foundations of international scientific interest in Middle Eastern populations to this day.
Author: Sergei Lukyanenko Publisher: Open Road Media ISBN: 1497643945 Category : Fiction Languages : en Pages : 470
Book Description
A science fiction thriller by the author of Night Watch, the hit novel that inspired two major motion pictures Five months after the horrific accident that left him near death and worried that he’d never fly again, master-pilot Alex Romanov lands a new job: captaining the sleek passenger vessel Mirror. Alex is a spesh—a human who has been genetically modified to perform particular tasks. As a captain and pilot, Alex has a genetic imperative to care for passengers and crew—no matter what the cost. His first mission aboard Mirror is to ferry two representatives of the alien race Zzygou on a tour of human worlds. His task will not be an easy one, for aboard the craft are several speshes who have reason to hate the Others. Dark pasts, deadly secrets, and a stolen gel-crystal worth more than Alex’s entire ship combine to challenge him at every turn. And as the tension escalates, it becomes apparent that greater forces are at work to bring the captain’s world crashing down.
Author: John Parrington
Author: John Parrington
Author: Spencer Wells
Author: Moyra Smith
Author: Eugene E. Harris (Professor)
Author: Lone Frank
Author: John Parrington
Author: Elise K. Burton
Author: Sergei Lukyanenko
Author: Susan Brooks Thistlethwaite
Author: David Scott Moore