Author: Alan M. GoldbergPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 788
Book Description
World Congress on Alternatives and Animal Use in the Life Sciences
Author: Alan M. GoldbergPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 788
Book Description
World Congress on Alternatives and Animal Use in the Life Sciences
Author: Animal Alternatives, Welfare, and Ethics
Author: L. F. M. (szerk.) ZuthpenPublisher: Elsevier Science & Technology
ISBN:
Category : Alternative toxicity testing
Languages : en
Pages : 1290
Book Description
Hardbound. The objective of this conference was to: - provide a global overview of the present status of replacement alternatives, reduction alternatives and refinement alternatives; - review the progress that has been made with respect to their implementation within the fields of biomedical research, testing and education; - promote the exchange of information on recent developments in animal alternatives; and - contribute to an ongoing dialogue between the animal protection movement, the scientific community, the regulatory authorities and industry. These objectives were fully achieved, and the results have been published in this volume.The contents of this book provide an up-to-date overview of the various aspects dealing with the development, validation and use of animal alternatives. In addition, current topics on animal welfare and ethical aspects of animal experiments are covered
Alternatives to Animal Testing
Author: Hajime KojimaPublisher: Springer
ISBN: 9811324476
Category : Medical
Languages : en
Pages : 130
Book Description
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
World Congress on Alternatives and Animal Use in the Life Sciences
Author: Animal Alternatives, Welfare and Ethics
Author: L. F. M. ZutphenProgress in the Reduction, Refinement, and Replacement of Animal Experimentation
Author: Michael BallsPublisher: Elsevier Science & Technology
ISBN:
Category : Medical
Languages : en
Pages : 948
Book Description
Hardbound. New legislation enacted in many countries and regions of the world during the 1980s requires that laboratory animal use be reduced, refined and replaced wherever possible, for ethical and scientific reasons, in line with the Three Rs concept put forward by W.M.S. Russell and R.L. Bnurch in 1958, in The Principles of Humane Experimental Technique. This Congress provided an opportunity for a celebration of the 40th anniversary of the publication of this book, and for a coming together of many of those who are actively pursuing the implementation of the Three Rs in the interests of good science and humane science.Current uses and future prospects for the use of laboratory animal procedures and non-animal methods in the biomedical sciences are considered in five themes: the development of replacement alternative methods; the validation and regulatory acceptance of alternative test methods; reduction alternatives and the testi
Hearing on the Nominations of Ann Dunkin to be Assistant Administrator, EPA Office of Environmental Information; Thomas Burke to be Assistant Administrator, EPA Office of Research and Development; and Jane Nishida to be Assistant Administrator, EPA Office of International and Tribal Affairs
Author: United States. Congress. Senate. Committee on Environment and Public WorksPublisher:
ISBN:
Category :
Languages : en
Pages : 108
Book Description
Alternatives to Animal Testing
Author: Hajime KojimaPublisher:
ISBN: 9789811324482
Category : Alternative toxicity testing
Languages : en
Pages : 130
Book Description
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments - replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R & D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
The History of Alternative Test Methods in Toxicology
Author: Publisher: Academic Press
ISBN: 0128136987
Category : Medical
Languages : en
Pages : 352
Book Description
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.