Author: Pınar Atukeren Publisher: BoD – Books on Demand ISBN: 1839688254 Category : Science Languages : en Pages : 160
Book Description
Lipid peroxidation can occur via either enzymatic or nonenzymatic reactions due to excess production of free radical molecules. This process culminates in cellular damage causing various diseases. This book examines lipid peroxidation as a current and future biomarker of oxidative stress.
Author: Angel Catalá Publisher: Nova Science Publishers ISBN: 9781536105308 Category : Science Languages : en Pages : 376
Book Description
This book presents an overview of lipid peroxidation: inhibition, effects and mechanisms. The topics analyzed, cover a broad spectrum of functions played by lipid peroxidation and presents new information in this area of research. The topics analyzed include: progress in the knowledge of lipid peroxidation, from the first evidences issued by Nicolas Theodore de Saussure in Paris 1804; fighting against lipid peroxidation: the unique story of docosahexaenoic acid in the brain; protective effects of melatonin and structurally-related molecules in reducing membrane rigidity due to lipid peroxidation; synergistic effects of antioxidant compositions during inhibited lipid autoxidation; lipid peroxidation and animal longevity; free radicals in health and disease; lipid peroxidation in autoimmune diseases; aldehydes derived from lipid peroxidation in cancer and autoimmunity; the role of reactive oxygen species and lipid peroxidation in the neurodegenerative process after spinal cord injury; kinetics and mechanisms of inhibited lipid autoxidation in presence of 4-substituted-coumarins; hypoxia and oxidative stress: cell signaling mechanisms and protective role of vitamin C and cilnidipine; characterization of oxidative stress and antioxidant potency; paying attention to time and location; lipid peroxidation in aquatic organisms: ontogenetic, phylogenetic and ecological aspects; chemistry of lipid oxidation in edible oils; and menopause progression and oxidative stress: associated mechanisms and the importance of physical exercise.
Author: Angel Catalá Publisher: Nova Science Publishers ISBN: 9781633218864 Category : Active oxygen Languages : en Pages : 0
Book Description
Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of generating pro-oxidative-free radical species. There are two broad outcomes to lipid peroxidation: structural damage to membranes and generation of secondary products. Membrane damage derives from the generation of fragmented fatty acyl chains, lipidlipid cross-links, lipidprotein cross-links and endocyclisation to produce isoprostanes and neuroprostanes. These processes combine to produce changes in the biophysical properties of membranes that can have profound effects on the activity of membrane-bound proteins. The consequence of peroxidation of unsaturated fatty acids is severe: damage of membranes function, enzymatic inactivation, toxic effects on the cellular division, etc. This new book presents and discusses current research on oxidative stress, and lipid oxidation non-inhibited and inhibited; assessment of oxidative balance in the lipo- and hydro-philic cellular environment in biological systems; mass spectrometry detection of protein modification by cross-reaction with lipid peroxidation products; diagonal gel electrophoretic analysis of protein disulfides: principles and applications. Other chapters describe: heavy metals exposure and cells oxidative damage; biodegradation of metallic biomaterials: its relation with the generation of reactive oxygen species; Oxidative modifications of proteins in the aging heart; role of reactive oxygen species as signalling molecules involved in the regulation of physiological processes of the nervous system; oxidative stress in diabetes and hypertension treated with alternative therapy of medicinal plants; impairment of redox homeostasis of tissue damage in inborn errors of metabolism with intoxication: insights from human and animal studies and finally lipid peroxidation of phospholipids in the vertebrate retina or in liposomes made of retinal lipids: similarities and differences are described.
Author: Carmen Vigo-Pelfrey Publisher: CRC-Press ISBN: 9780849340710 Category : Science Languages : en Pages : 232
Book Description
This two-volume text compiles the efforts of distinguished scientists nd focuses on the formation of free radicals, toxic effects of lipoperoxides, biological antioxidant protection against lipid peroxidation damage, and pathological implications of lipid peroxidation. This review also addresses vitamin E deficiency, carbon tetrachloride and ethanol poisoning, radiation damage, hyperbaric effects, tumors, aging, diabetes, liver degeneration, DNA damage, lipoprotein modification and artherosclerosis, multiple sclerosis, angiopathy, Parkinson's disease, lupus, and many other degenerative diseases. It is an excellent resource for biological chemist, cell biologists, and all who are interested in the pharmaceutical sciences.
Author: Kunio Yagi Publisher: Elsevier ISBN: 0323153453 Category : Medical Languages : en Pages : 376
Book Description
Lipid Peroxides in Biology and Medicine emphasizes the importance of the control of lipid peroxides in the body for the prevention and treatment of degenerative diseases. This book discusses the production of free radicals in vivo from the action of xenobiotics, and comparative aspects of several model lipid peroxidation systems. The lipid peroxidation and membrane alterations in erythrocyte survival, and lipid peroxidations of cholesterol are also deliberated. This text likewise covers the mechanism of protection against membrane peroxidation, lipid peroxides as a cause of vascular diseases, and peroxide-mediated metabolic activation of carcinogens. Other topics include lipid peroxide in aging process and production of ethane and pentane during lipid peroxidation. This publication is valuable to biologists, medical practitioners, and clinicians researching on lipid peroxides.
Author: Werner Siems Publisher: IOS Press ISBN: 9781586035860 Category : Medical Languages : en Pages : 338
Book Description
Focuses on products of lipid peroxidation used as biomarkers of oxidative stress. This book covers the entire field of HNE research, including subjects as Cell Cycle and Proteolysis, LPO Products, Antioxidants and Detoxification, Neurodegeneration and Aging, Lipid Peroxidation, HNE and Gene Regulation, Clinical Applications and HNE, and more.
Author: Valerian E. Kagan Publisher: CRC Press ISBN: 1351090984 Category : Medical Languages : en Pages : 189
Book Description
This book will explain the colossal potential of life to cope with different living environments is possible owing to the exceptionally well developed mechanisms of adaptation to environmental conditions. There is an innumerable variety of concrete mechanisms which make it possible for living creatures to adapt to different and changing environmental conditions. Nevertheless, all this variety is the manifestation of the three strategic line of the adaptation process: 1. Evolutional or genotypic adaptation. 2. Phenotypic adaptation. 3. Rapid adaptation.
Author: A. Crastes de Paulet Publisher: Springer Science & Business Media ISBN: 1468474278 Category : Medical Languages : en Pages : 405
Book Description
This book contains the proceedings of the ARW NATO Conference on "Action of Free Radicals and Active Forms of Oxygen on Lipoproteins and Membrane Lipids: Cellular Interactions and Atherogenesis", held in Bendor, France, October 5-8,1988. Since the pioneer work of Mc Cord and Fridovitch, growing interest has been focused on the study of the role of oxyradicals role in pathology. This interest is reflected in the exponential increase in the number of papers on free radicals, the success of specialized journals and books on this theme, and the organization of national and international meetings. These meetings have discussed, from.a broad point of view, the problems concerning the mechanisms of production of free radicals, their effects on cell CO!1$tituants (lipids, proteins, nucleic acids) and cell function, the methods of analysis of these phenomena, the pathological states in which free radicals may be involved, natural biological defense systems, and the design of "antiradical" therapies. But it is now well established that the most common target of oxy free radicals are membrane lipids because of their chemical nature (cholesterol in saturation, malonic linkage of polyunsaturated fatty acids (PUFA» and of their regular structural arrangement (monolayers in lipoproteins, bilayers in cell membranes). Thus the analysis of the products resulting from the action of oxy free radicals on PUFA is considered the best tool to indirectly evaluate the effects of tissue peroxidations, although the analytical basis for doing so is very questionable.
Author: Mahmoud Ahmed Mansour Publisher: BoD – Books on Demand ISBN: 1839685476 Category : Science Languages : en Pages : 130
Book Description
Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases.
Author: Pınar Atukeren
Author: Alex Sevanian
Author: Angel Catalá
Author: Angel Catalá
Author: Carmen Vigo-Pelfrey
Author: Kunio Yagi
Author: Werner Siems
Author: Valerian E. Kagan
Author: A. Crastes de Paulet
Author: Mahmoud Ahmed Mansour