Magnetic Resonance Spectroscopy and Imaging in Neurochemistry PDF Download

Author: Herman Bachelard
Publisher: Springer Science & Business Media
ISBN: 1461558638
Category : Medical
Languages : en
Pages : 427

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Book Description
The Advances in Neurochemistry series was initiated for a readership of neuroscientists with a background in biochemistry. True to this concept, the present volume brings together various applications of magnetic resonance technology to advance our knowledge of how the nervous system functions. Whether at the cellular, tissue slice, or intact organism level. magnetic resonance techniques are by their nature noninvasive, and thus provide a window through which biochemical reactions can be viewed without grinding, binding, or other wise perturbing ongoing physiological processes. As technological improve ments in methodology, such as higher and more uniform magnetic fields, novel paradigms for data analysis, etc. , are made, we find increased sensitivity and improved temporal and spatial resolution for functional imaging techniques on the one hand, and better separation of signals that identify chemical properties in spectral shift studies, on the other. It is upon knowledge such as is described in the twelve chapters that follow, that further advances in scientific discovery and the biomedical applications of tomorrow will be based. We are grateful to Dr. Bachelard, the Volume Editor, and to the authors of the individual chapters for their efforts. We also note that with this volume Dr. Morris Aprison, a co-founder of the Advances in Neurochemistry series has stepped down and acknowledge with thanks his major role in its inception. In addition, we thank our past and present Advisory Editors. Bernard W. Agranoff Kunihiko Suzuki Series Editors ix CONTENTS LIST OF SYMBOLS AND GLOSSARY . . . . . . . . . . . . . . . . . . . . . . . . . . . XXI INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Author: Charlotte Stagg
Publisher: Academic Press
ISBN: 0124016979
Category : Medical
Languages : en
Pages : 398

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Book Description
Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective. Chapters written by world-leading experts in the field Fully illustrated Covers both proton and non-proton MRS Includes the background to novel MRS imaging approaches

Author: Bernard W. Agranoff
Publisher:
ISBN:
Category : Neurochemistry
Languages : en
Pages :

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Author: Lara Alexandre Brandão
Publisher: Lippincott Williams & Wilkins
ISBN: 0781746167
Category : Medical
Languages : en
Pages : 426

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Book Description
This volume is a practical guide to the technique and most frequent clinical applications of magnetic resonance spectroscopy (MRS) of the brain. Using more than 500 images, the authors present the fundamentals of MRS in a straightforward fashion and show radiologists and neurologists how to recognize normal and disease processes on scans. The book presents the spectra of the most common neurological disease entities, along with the conventional images and perfusion and diffusion where appropriate. The authors thoroughly describe the pathology and key MRS features of each disease process. Each chapter ends with a quick-reference summary of the main findings.

Author: M. Filippi
Publisher: Springer Science & Business Media
ISBN: 884702109X
Category : Medical
Languages : en
Pages : 153

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Book Description
Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

Author: Peter B. Barker
Publisher: Cambridge University Press
ISBN: 052186898X
Category : Medical
Languages : en
Pages : 275

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Book Description
Covers all MR spectroscopy techniques and their clinical applications in neurological disorders, malignancies and musculoskeletal diseases.

Author: Suresh K. Mukherji
Publisher: Wiley-Liss
ISBN: 9780471161783
Category : Medical
Languages : en
Pages : 0

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Book Description
Clinical Applications of MR Spectroscopy Edited by Suresh K. Mukherji, M.D. Magnetic resonance spectroscopy (MRS) is a powerful diagnostic tool for a variety of brain disorders—from epilepsy and tumors to age-related degeneration and strokes. Unlike magnetic resonance imaging (MRI), which gives us a picture of anatomical and physiological conditions, MRS generates a frequency domain spectrum that provides information about biochemical and metabolic processes occurring within tissues. Clinical Applications of MR Spectroscopy presents a short, practical treatment of MRS today. Comprising contributions by leading authorities in the field, the book discusses MRS techniques used for diagnostic purposes and research, terminologies and examples drawn from clinical experience, and ways to correlate MRS results with other modalities to enhance our understanding of disease processes and the outcomes of particular treatments. Topics include: Basic principles of clinical proton magnetic resonance spectroscopy MRS in the evaluation of epilepsy Proton MRS of brain tumors Proton MRS in selected childhood disorders MRS and spectroscopic imaging for cerebrovascular disease MRS of degenerative brain disease in the elderly MRS of the head and neck Potential clinical applications of new techniques in MRS Correlation of functional brain imaging with MRS Clinical Applications of MR Spectroscopy provides 150 photographs and figures to illustrate the interpretation of MRS signals, as well as fully referenced chapters for those wishing to expand their knowledge of the underlying science. It is an essential guide to the state of the art for radiologists and neurologists using this technology to improve patient care.

Author: Semyon M. Slobounov
Publisher: Springer Science & Business Media
ISBN: 0387325654
Category : Medical
Languages : en
Pages : 482

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Book Description
In summarizing current insights and controversies over concussions in athletics, this book makes the vital point that symptom resolution does not necessarily mean injury resolution. Research shows that dysfunctional pathways continue for extended periods even after a minor concussion. Until the consequences of short-term perturbations and long-term residual brain dysfunctions are better understood, concussions must be treated with respect and given a higher priority for continued research activity.

Author: Robin A. de Graaf
Publisher: John Wiley & Sons
ISBN: 1119382548
Category : Science
Languages : en
Pages : 584

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Book Description
Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

Author: H. S. Bachelard
Publisher: Springer
ISBN: 1489933921
Category : Medical
Languages : en
Pages : 72

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Book Description
The brain is the most complex and highly of semi-permeable excitable membranes which specialised of all mammalian organs. Under can be caused, rapidly and transiently, to under standing the complexity of its function remains go changes in permeability to small chemical man's greatest challenge. The functional unit is molecules and to cations. The highly specialised the neurone, or excitable nerve cell, making ana nature of the constituent cells, with their unique tomical and chemical connections with other function and specificity, is c10sely related to units in the system. Many of the essential bio the structure of the whole tissue. The underlying chemical connections of the nerve cell are de chemical processes cannot be discussed or seen pendent upon special morphological features: in perspective without constant awareness of synaptic contact is mediated by chemical mol related aspects of physiology and morphology. ecules, 'neuro-transmitters' which ensure the The hrain is structurally extraordinarily com continued propagation of electrical impulses plex in its distinct anatomical regions, each of through sequential units of the system. Also which is heterogeneous in the types and struc c10sely related to the morphology of the ner tures of the constituent cells. vous system is the chemical energy expended in One aspect of the biochemical function of maintaining distribution gradients of cations the brain can be seen in its efficient production across cellular membranes. Chemical neuro of the energy required to support the unique pro transmission results in an alteration in cation cesses referred to above.