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Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1119959667 Category : Medical Languages : en Pages : 238
Book Description
Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1119959667 Category : Medical Languages : en Pages : 238
Book Description
Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 0470654899 Category : Medical Languages : en Pages : 0
Book Description
One of the latest techniques in drug delivery, microneedles are used for administering a wide range of drug substances used to treat various medical conditions. Thorough background information is included providing a history of the field. Various methods used to produce micorneedles are described as well as a snapshot of the future directions within the industry. Written by highly qualified authors, this new text is the only title providing a comprehensive review of microneedle research in the fields of transdermal and intradermal drug delivery.
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1118734513 Category : Science Languages : en Pages : 290
Book Description
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1119305179 Category : Science Languages : en Pages : 352
Book Description
Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.
Author: Chenjie Xu Publisher: John Wiley & Sons ISBN: 3527344608 Category : Science Languages : en Pages : 498
Book Description
Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments. * Presents up-to-date knowledge of the skin biology and pathologies * Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts * Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research * Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1119305144 Category : Science Languages : en Pages : 349
Book Description
Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.
Author: Kevin Ita Publisher: Academic Press ISBN: 0323972349 Category : Medical Languages : en Pages : 266
Book Description
Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study. Provides information for the design and fabrication of microneedles Discusses choice of materials, fabrication protocol, sterilization protocol and characterization Supplies the most up-to-date research on all aspects of microneedles
Author: Ryan F. Donnelly Publisher: John Wiley & Sons ISBN: 1118734483 Category : Science Languages : en Pages : 296
Book Description
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.
Author: Hiep Xuan Nguyen Publisher: CRC Press ISBN: 100089780X Category : Technology & Engineering Languages : en Pages : 448
Book Description
The microneedle field has been expanding exponentially with innovative designs and various applications, thus capturing the interest of academic industry and regulatory sectors. Microneedles: The Future of Drug Delivery equips readers with a comprehensive understanding of microneedles: from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles. This book is written by a single author and thus provides complex information in a simple, elegant, and cohesive style. The book is intended for graduate students, researchers, scientists, and engineers working in the pharmaceutical, medical, cosmeceutical, and biotechnology industry.
Author: Kevin Ita Publisher: Academic Press ISBN: 0128225513 Category : Business & Economics Languages : en Pages : 324
Book Description
Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems
Author: Ryan F. Donnelly
Author: Ryan F. Donnelly
Author: Ryan F. Donnelly
Author: Ryan F. Donnelly
Author: Ryan F. Donnelly
Author: Chenjie Xu
Author: Ryan F. Donnelly
Author: Kevin Ita
Author: Ryan F. Donnelly
Author: Hiep Xuan Nguyen
Author: Kevin Ita