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Author: Fouad R. Kandeel Publisher: CRC Press ISBN: 1420015087 Category : Medical Languages : en Pages : 560
Book Description
Although impotence may be the most widely recognized manifestation of male sexual dysfunction, many other forms of sexual disorders do not involve the erectile mechanism, from deficiencies of desire to disturbances in ejaculatory function to the failure of detumescence. With such a myriad-and often co-existing-number of disorders, the successful tr
Author: Fouad R. Kandeel Publisher: CRC Press ISBN: 1420015087 Category : Medical Languages : en Pages : 560
Book Description
Although impotence may be the most widely recognized manifestation of male sexual dysfunction, many other forms of sexual disorders do not involve the erectile mechanism, from deficiencies of desire to disturbances in ejaculatory function to the failure of detumescence. With such a myriad-and often co-existing-number of disorders, the successful tr
Author: Daniel Scherman Publisher: World Scientific ISBN: 1786346893 Category : Science Languages : en Pages : 634
Book Description
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Author: Olivier Rabin Publisher: Springer Nature ISBN: 3030792935 Category : Medical Languages : en Pages : 270
Book Description
Athletes are always aiming to be faster, better, stronger. New techniques to enhance their sporting performance have increasingly been linked to use of novel psychoactive substances (NPS) and other hard-to-detect substances like performance-enhancing drugs. This book offers a timely analysis of the new challenges posed by this phenomenon in the anti-doping community. The authors present the first comprehensive perspective on the rapidly shifting doping scenario and reflect on use, regulation, policy, and market structure of NPS used in sports. They highlight the challenges with the list of prohibited substances and methods in and out of competition. They also evaluate how methods to detect new drugs present an ongoing battle for doping control as they have to be adapted constantly. Topics covered within the chapters include: Contamination of Sports Supplements with Novel Psychoactive Substances Untested Supplement Use Among Athletes: An Overlooked Phenomenon? International Drug Control: Protecting the Health of the Athlete Analysis of New Chemical Entities in a Sport Context Emerging Drugs in Sport establishes a clear benchmark on the policy discussion, drawing from available evidence and sources, including athletes' personal experiences, to generate a fact-based resource that informs a research as well as wider audience. The book is essential reading for those working in anti-doping, substance misuse, sports, ethics, and human enhancement. It also is useful for policy-makers, legislative personnel, and other professionals with an interest in protecting clean sport. “Doping is one of the greatest threats to the integrity of sport. We must never be tempted to turn our back on the problem and hope it will disappear. The benefits and values of clean sport have never been more important to the world. That is why this book with its wide-ranging approach is so valuable.” Thomas Bach, President, International Olympic Committee “Physical activity is vital to a healthy living, which is why doping is not just an assault on fair competition, but also on health. I strongly commend this book for compiling advanced knowledge on performance-enhancing drugs and promoting health through sport.” Tedros Adhanom Ghebreyesus, Director-General, World Health Organization
Author: Hans-Peter Meyer Publisher: John Wiley & Sons ISBN: 3527335471 Category : Science Languages : en Pages : 642
Book Description
The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.
Author: Odile Cohen-Haguenauer Publisher: EDK Editions ISBN: 2842542371 Category : Medical Languages : en Pages : 589
Book Description
This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. Dr Odile Cohen-Haguenauer is the Coordinator of Clingene-NoE, the European Network for the Advancement of Clinical Gene Transfer and Therapy.
Author: Odile Cohen-Haguenauer Publisher: EDK Editions ISBN: 9782842542375 Category : Medical Languages : en Pages : 588
Book Description
This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. Dr Odile Cohen-Haguenauer is the Coordinator of Clingene-NoE, the European Network for the Advancement of Clinical Gene Transfer and Therapy.
Author: Philip Mayles Publisher: CRC Press ISBN: 0429510160 Category : Science Languages : en Pages : 1463
Book Description
From the essential background physics and radiobiology to the latest imaging and treatment modalities, the updated second edition of Handbook of Radiotherapy Physics: Theory & Practice covers all aspects of the subject. In Volume 1, Part A includes the Interaction of Radiation with Matter (charged particles and photons) and the Fundamentals of Dosimetry with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers, solid-state detectors, film and gels, as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or ‘algorithms’) for Computing Doses in Patients irradiated by photon, electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms. In Volume 2, Part G covers all aspects of Treatment Planning including CT-, MR- and Radionuclide-based patient imaging, Intensity-Modulated Photon Beams, Electron and Proton Beams, Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes are covered in Part H. Radionuclides, equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J, respectively. Finally, Part K is devoted to Radiation Protection of the public, staff and patients. Extensive tables of Physical Constants, Photon, Electron and Proton Interaction data, and typical Photon Beam and Radionuclide data are given in Part L. Edited by recognised authorities in the field, with individual chapters written by renowned specialists, this second edition of Handbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists, radiation oncologists, radiation technologists, PhD and Master’s students.
Author: Birgitta Qvarsell, Christoph Wulf Publisher: Waxmann Verlag ISBN: 9783830962274 Category : Education Languages : en Pages : 244
Book Description
Although the educational system still fulfills the task of anchoring young generations within the national cultures that make up Europe, the progressive loss of significance of national states, which is connected to the process of unification and globalization, is creating new challenges to the various European cultures and to the education systems embodied in their people. Cultures are sustained and transformed through the manner in which they communicate with the younger generation; it is at this level that they constitute their particular power and dynamic.
Author: United States. Supreme Court. Advisory Committee on Rules of Criminal Procedure Publisher: ISBN: Category : Court rules Languages : en Pages : 700
Author: Fouad R. Kandeel
Author: Fouad R. Kandeel
Author: Daniel Scherman
Author: Olivier Rabin
Author: 
Author: Hans-Peter Meyer
Author: Odile Cohen-Haguenauer
Author: Odile Cohen-Haguenauer
Author: Philip Mayles
Author: Birgitta Qvarsell, Christoph Wulf
Author: United States. Supreme Court. Advisory Committee on Rules of Criminal Procedure