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Author: Jianren Mao Publisher: Nova Publishers ISBN: 9781600212055 Category : Pain Languages : en Pages : 370
Book Description
Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).
Author: Jianren Mao Publisher: Nova Publishers ISBN: 9781600212055 Category : Pain Languages : en Pages : 370
Book Description
Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).
Author: Publisher: Academic Press ISBN: 008088783X Category : Medical Languages : en Pages : 5944
Book Description
Hormones, Brain, and Behavior, Second Edition is a comprehensive work discussing the effect of hormones on the brain and, subsequently, behavior. This major reference work has 109 chapters covering a broad range of topics with an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. To truly understand all aspects of our behavior, we must take every influence (including the hormonal influences) into consideration. Donald Pfaff and a number of well-qualified editors examine and discuss how we are influenced by hormonal factors, offering insight, and information on the lives of a variety of species. Hormones, Brain, and Behavior offers the reader comprehensive coverage of growing field of research, with a state-of-the-art overview of hormonally-mediated behaviors. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Available online exclusively via ScienceDirect. A limited edition print version is also available. Comprehensive coverage of a growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunites for relating behavior to molecular genetics Covers an unusual breadth ranging from molecules to ecophysiology, and from basic science to clinical research
Author: Lawrence Kruger Publisher: CRC Press ISBN: 1439812101 Category : Health & Fitness Languages : en Pages : 432
Book Description
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
Author: Hermann O. Handwerker Publisher: Lippincott Williams & Wilkins ISBN: 1496331931 Category : Medical Languages : en Pages : 914
Book Description
The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model.
Author: National Research Council Publisher: National Academies Press ISBN: 030921954X Category : Science Languages : en Pages : 42
Book Description
The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Author: Daniel Laskowitz Publisher: CRC Press ISBN: 1498766579 Category : Medical Languages : en Pages : 412
Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Author: Felipe Sierra Publisher: Springer ISBN: 3319232460 Category : Medical Languages : en Pages : 622
Book Description
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309145449 Category : Medical Languages : en Pages : 436
Book Description
Collaborations of physicians and researchers with industry can provide valuable benefits to society, particularly in the translation of basic scientific discoveries to new therapies and products. Recent reports and news stories have, however, documented disturbing examples of relationships and practices that put at risk the integrity of medical research, the objectivity of professional education, the quality of patient care, the soundness of clinical practice guidelines, and the public's trust in medicine. Conflict of Interest in Medical Research, Education, and Practice provides a comprehensive look at conflict of interest in medicine. It offers principles to inform the design of policies to identify, limit, and manage conflicts of interest without damaging constructive collaboration with industry. It calls for both short-term actions and long-term commitments by institutions and individuals, including leaders of academic medical centers, professional societies, patient advocacy groups, government agencies, and drug, device, and pharmaceutical companies. Failure of the medical community to take convincing action on conflicts of interest invites additional legislative or regulatory measures that may be overly broad or unduly burdensome. Conflict of Interest in Medical Research, Education, and Practice makes several recommendations for strengthening conflict of interest policies and curbing relationships that create risks with little benefit. The book will serve as an invaluable resource for individuals and organizations committed to high ethical standards in all realms of medicine.
Author: Peter Keating Publisher: University of Chicago Press ISBN: 022614304X Category : Medical Languages : en Pages : 475
Book Description
There were no medical oncologists until a few decades ago. In the early 1960s, not only were there no such specialists, many practitioners regarded the treatment of terminally-ill cancer patients with heroic courses of chemotherapy as highly questionable. Physicians loath to assign patients randomly to competing treatments also expressed their outright opposition to the randomized clinical trials that were then relatively rare. And yet today these trials form the basis of medical oncology. How did such a spectacular change occur? How did medical oncology move from a non-entity and in some regards a reviled practice to the central position it now occupies in modern medicine? Cancer on Trial answers these questions by exploring how practitioners established a new style of practice, at the center of which lies the cancer clinical trial.
Author: Jianren Mao
Author: Jianren Mao
Author: 
Author: Lawrence Kruger
Author: Hermann O. Handwerker
Author: National Research Council
Author: Daniel Laskowitz
Author: Felipe Sierra
Author: Institute of Medicine
Author: Peter Keating
Author: