Nutrigenomics and Proteomics in Health and Disease PDF Download

Author: Martin Kussmann
Publisher: John Wiley & Sons
ISBN: 1119098831
Category : Technology & Engineering
Languages : en
Pages : 350

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Book Description
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

Author: Jennifer E. Van Eyk
Publisher: John Wiley & Sons
ISBN: 3527622160
Category : Science
Languages : en
Pages : 694

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Book Description
Unparalleled in its scope and depth, this book brings together proteomic approaches in diagnosis and treatment from all clinical fields, including clinical toxicology. The result is a new discipline in molecular medicine that will revolutionize the treatment and prevention of cancer, stroke and other severe diseases. Following an overview of clinical proteomics, the authors look at the technologies available, before moving on to cancer, cardiopulmonary disease, diabetes and stroke. A whole section is devoted to toxicity and the work is rounded off with a discussion of the future of clinical proteomics.

Author: T.D. Veenstra
Publisher: IOS Press
ISBN: 9781586034344
Category : Diagnosis
Languages : en
Pages : 88

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Book Description
For many diseases, such as heart disease and cancer, early detection plays a pivotal role in the survival rate of the patient. When detected early, many such lethal diseases can be effectively treated with existing remedies. The difficulty remains, however, how to effectively detect such conditions at the earliest possible stage with a high enough positive predictive value so that they can be treated effectively without overwhelming the medical system with false positive diagnoses. What is required is the identification of more effective or additional biomarkers, as well as other types of technologies, that can aid in the diagnosis of early stage diseases. The challenge is how to identify more effective biomarkers or technologies that can provide an earlier indication of a disease with a higher positive predictive value than presently utilized methods. Proteomics, along with genomics and transcriptomics, has benefited greatly from the development of high-throughput methods to study thousands of proteins almost simultaneously.Based on the rate of interesting leads already being discovered using proteomics, it is likely that not only will biomarkers with better sensitivity and specificity be identified but individuals will be treated using customized therapies based on their specific protein profile. Since many of the proteomic technologies and data management tools are still in their infancy, the future of proteomics in disease diagnostics looks extremely promising.

Author: S. Hanash
Publisher: IOS Press
ISBN: 9781586032494
Category : Medical
Languages : en
Pages : 116

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Book Description
This volume examines the field of proteomics, which holds great promise for identifying non-targeted, global molecular profiles signatures of normal and diseased cells. While genomics offers a wide array of tools for identifying mutated or dysregulated genes, proteomics offers the ability to measure post-translational modifications, protein stability, phosphorylation state, protein-protein interactions and protein DNA-binding affinities.

Author: Haleem J. Issaq
Publisher: Academic Press
ISBN: 0128197889
Category : Science
Languages : en
Pages : 504

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Book Description
Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Author: Ambikanandan Misra
Publisher: Elsevier
ISBN: 0123849659
Category : Science
Languages : en
Pages : 686

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Book Description
Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

Author: Shafat Ali
Publisher: Elsevier
ISBN: 0323950736
Category : Science
Languages : en
Pages : 414

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Book Description
Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment. The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice. Provides up-to-date information on current cancer proteomics research developed globally Presents basic research aspects to clinical implications of proteomics on cancer diagnosis and potential treatments Discusses challenges and future developments of the field to leverage further research and applicability in clinical setting

Author: Jean-Charles Sanchez
Publisher: John Wiley & Sons
ISBN: 3527605835
Category : Science
Languages : en
Pages : 452

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Book Description
In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.

Author: Alka Dwevedi
Publisher: Wiley-Blackwell
ISBN: 9781119503194
Category : Science
Languages : en
Pages : 0

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Book Description
Approximately 30,000 genes are functional while other genes in the genome are not expressed. Expressed genes are necessary for proper functioning of all the systems present in humans. Therefore, an approach towards the understanding of expressed genes (i.e. proteins), which is termed as the "proteome" is helpful in understanding all life processes. Proteomics would be very helpful in detailed analyses of diseased states and suitable treatment protocols. Most diseases are detected late, which usually results in less effective treatment. Proteomics would be the best tool for early disease detection and thus accelerating drug development at a higher pace with respect to their dosage and toxicity. There are various methods of disease diagnosis--however, the application of proteomics in disease diagnosis has been given priority due to its ability of identifying important disease markers accurately. This is helpful for faster disease diagnosis, as well as effective therapeutics. This method is based on the protein profiling of diseased and normal tissues/cells and their comparative analyses. It can be directly used by taking biological samples in very small amounts and giving higher throughput with respect to any other known techniques. An overview of important applications of proteomics in disease diagnosis and therapeutics include: Cancer diagnosis and therapeutics; Diagnosis of infectious diseases and treatment; Applications to prognosis; and finally Drug Development.

Author: Antonia Vlahou
Publisher: Springer Science & Business Media
ISBN: 158829837X
Category : Science
Languages : en
Pages : 401

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Book Description
In this book, a select group of researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. The book integrates biochemistry, pathology, analytical technology, bioinformatics, and proteome informatics. Experimental approaches are thoroughly detailed and explained through a step-by-step instructional format that ensures successful results.