Fungal Secondary Metabolism PDF Download

Author: Nancy P. Keller
Publisher: Humana Press
ISBN: 9781493959600
Category : Medical
Languages : en
Pages : 302

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Book Description
This Methods in Molecular Biology volume provides key methodologies for accessing and exploiting natural product information provided by the genomes of filamentous fungi. Includes materials and reagents lists, step-by-step protocols and troubleshooting tips."

Author: Richard J. Cole
Publisher: Gulf Professional Publishing
ISBN: 9780121794637
Category : Science
Languages : en
Pages : 696

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Book Description
This three-volume set is a desirable reference for a wide range of specialists who study secondary fungal metabolites ranging from pharmaceutical house researchers, agricultural researchers, those involved in food and feed control regulation, and veterinary researchers. It discusses in depth the molecular formula of, the molecular weights of, and fungal/plant source indexes of secondary fungal metabolites.

Author: Jean-Michel Mérillon
Publisher: Springer
ISBN: 9783319250007
Category : Science
Languages : en
Pages : 0

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Book Description
This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g. as anticancer agents, to microbial synthesis, even spanning to the production of secondary metabolites on industrial scale. On the other hand it also describes global health issues related to aflatoxin production in foods and agriculture, including perspectives for detoxification. The handbook characterizes different compound classes derived from fungal secondary metabolites, like ergot alkaloids and aflatoxins. The discussion puts a special emphasis on how potentially useful compounds can be obtained and what applications they can find, on the one hand, and how potential dangers can be encountered on the other hand. The comprehensive chapters in this handbook will thus appeal to readers from diverse backgrounds in chemistry, biology, life sciences, and even medicine, who are working or planning to work with fungal (secondary) metabolites and their application. They provide the readers with rich sources of reference information on important topics in this field.

Author: Nancy Keller
Publisher: Frontiers Media SA
ISBN: 2889451364
Category : Electronic book
Languages : en
Pages : 205

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Book Description
Fungal natural products are friends and foes of humans such as deleterious mycotoxins, cytotoxic, carcinogenic compounds or beneficial compounds such as antibiotics, fungicides, insecticides, antiviral and antitumor metabolites. Understanding fungal diversity and estimation of fungal species on our planet poses a great challenge to researchers. This complexity is further multiplied by secondary metabolite diversity of fungi, which requires interdisciplinary studies. It is extremely important to understand the fungal secondary metabolism to stop human, animal and plant diseases caused by fungi and harvest their valuable metabolites. Furthermore, many secondary metabolite gene clusters are silenced under laboratory conditions. It is vital to develop effective methods to activate those clusters in order to discover novel potent metabolites. This e-book is a compilation of original review articles contributed by leading fungal secondary metabolite researchers with a wide range of expertise. Important aspects of fungal secondary metabolism, including regulation, genome mining, evolution, synthetic biology and novel methods have been discussed. This book will be a great source to those people, who are interested in understanding overall structure, diversity and regulation of production of these tiny but precious chemicals.

Author: W. B. Turner
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 646

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Book Description
Primary and secondary metabolism; Fungi, their cultivation and their secondary metabolism; Secondary metabolites derived without the intervention of acetate; Secondary metabolites derived from fatty acids; Polyketides; Terpenes and steroids; Secondary metabolites derived from intermediates of the tricarboxylic acid cycle; Secondary metabolites derived from amino-acids; Miscellaneous secondary metabolites; Addendum; Formula index; Organism index; Subject index.

Author: Petr Karlovsky
Publisher: Springer Science & Business Media
ISBN: 3540745432
Category : Science
Languages : en
Pages : 294

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Book Description
Microbiologists and soil scientists will find this study compelling reading. It focuses on the role of bacterial, fungal and plant secondary metabolites in soil ecosystems. Our understanding of the biological function of secondary metabolites is surprisingly limited, considering our knowledge of their structural diversity and pharmaceutical activity. This book reviews functional aspects of secondary metabolite production, with a focus on interactions among soil organisms.

Author: Juan-Francisco Martín
Publisher: Springer
ISBN: 1493911910
Category : Science
Languages : en
Pages : 351

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Book Description
This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length Written by authorities in the field, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.

Author: Susanne Zeilinger
Publisher: Springer
ISBN: 1493925318
Category : Science
Languages : en
Pages : 256

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Book Description
​Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

Author: Joseph Heitman
Publisher: John Wiley & Sons
ISBN: 1555819583
Category : Medical
Languages : en
Pages : 1136

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Book Description
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.

Author: Ahmed M. Abdel-Azeem
Publisher: Springer Nature
ISBN: 3030675610
Category : Science
Languages : en
Pages : 609

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Book Description
Fungi are an understudied, biotechnologically valuable group of organisms. Due to their immense range of habitats, and the consequent need to compete against a diverse array of other fungi, bacteria, and animals, fungi have developed numerous survival mechanisms. However, besides their major basic positive role in the cycling of minerals, organic matter and mobilizing insoluble nutrients, fungi have other beneficial impacts: they are considered good sources of food and active agents for a number of industrial processes involving fermentation mechanisms as in the bread, wine and beer industry. A number of fungi also produce biologically important metabolites such as enzymes, vitamins, antibiotics and several products of important pharmaceutical use; still others are involved in the production of single cell proteins. The economic value of these marked positive activities has been estimated as approximating to trillions of US dollars. The unique attributes of fungi thus herald great promise for their application in biotechnology and industry. Since ancient Egyptians mentioned in their medical prescriptions how they can use green molds in curing wounds as the obvious historical uses of penicillin, fungi can be grown with relative ease, making production at scale viable. The search for fungal biodiversity, and the construction of a living fungi collection, both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products. Fungi have provided the world with penicillin, lovastatin, and other globally significant medicines, and they remain an untapped resource with enormous industrial potential. Volume 1 of Industrially Important Fungi for Sustainable Development provides an overview to understanding fungal diversity from diverse habitats and their industrial application for future sustainability. It encompasses current advanced knowledge of fungal communities and their potential biotechnological applications in industry and allied sectors. The book will be useful to scientists, researchers, and students of microbiology, biotechnology, agriculture, molecular biology, and environmental biology.