Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets PDF Download

Author: Sikha Saha
Publisher: Frontiers Media SA
ISBN: 2889634426
Category :
Languages : en
Pages : 317

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Book Description

Author: Sikha Saha
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author: Chiara Villa
Publisher:
ISBN: 9783036554853
Category :
Languages : en
Pages : 0

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Book Description
Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors and epigenetic mechanisms underlying neurodegenerative processes, which lead to increased prevalence of neurodegenerative disorders. In concert with the constant increase in the aging population, neurodegenerative disorders currently represent a major challenge to public health worldwide. Despite recent advances in clinical and preclinical research, the pathogenesis of these disorders still remains poorly understood, without effective treatments being available to halt the neurodegenerative processes, but rather aiming at relieving symptoms. Therefore, a critical evaluation of current research data and in-depth understanding of the molecular mechanisms that lead to neurodegeneration are crucial in order to identify potential therapeutic targets that can pave the way to the development of novel and promising therapies. This Special Issue is focused on novel molecular data in the field of neurodegeneration that associate with the onset and progression of neurodegenerative diseases. We are particularly interested in original articles and reviews that provide new insights into the main molecular pathogenic mechanisms underlying neurodegenerative disorders, aiming to identify potential biomarkers and novel therapeutic strategies.

Author: Yam Nath Paudel
Publisher: Mdpi AG
ISBN: 9783036554860
Category :
Languages : en
Pages : 0

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Book Description
Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors and epigenetic mechanisms underlying neurodegenerative processes, which lead to increased prevalence of neurodegenerative disorders. In concert with the constant increase in the aging population, neurodegenerative disorders currently represent a major challenge to public health worldwide. Despite recent advances in clinical and preclinical research, the pathogenesis of these disorders still remains poorly understood, without effective treatments being available to halt the neurodegenerative processes, but rather aiming at relieving symptoms. Therefore, a critical evaluation of current research data and in-depth understanding of the molecular mechanisms that lead to neurodegeneration are crucial in order to identify potential therapeutic targets that can pave the way to the development of novel and promising therapies. This Special Issue is focused on novel molecular data in the field of neurodegeneration that associate with the onset and progression of neurodegenerative diseases. We are particularly interested in original articles and reviews that provide new insights into the main molecular pathogenic mechanisms underlying neurodegenerative disorders, aiming to identify potential biomarkers and novel therapeutic strategies.

Author: Otto Warburg
Publisher: EnCognitive.com
ISBN: 1927091179
Category : Health & Fitness
Languages : en
Pages : 419

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Book Description
This is book 2 of 5 of the “Understand Cancer” series. It is based on the best-available science. The SECONDARY causes of cancer were discussed in book one. This book continues from book one and discusses the PRIME cause of cancer as discovered by Nobel Prize Laureate Dr. Otto Warburg—considered by many as the founder of modern biochemistry. “There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.” —Dr. Otto Warburg

Author:
Publisher: Academic Press
ISBN: 0128138335
Category : Medical
Languages : en
Pages : 294

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Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Author: Marie-Francoise Chesselet
Publisher: Springer Science & Business Media
ISBN: 1592590063
Category : Medical
Languages : en
Pages : 416

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Book Description
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Author: Natalia N Nalivaeva
Publisher: Frontiers Media SA
ISBN: 2889631176
Category :
Languages : en
Pages : 162

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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author: Mauro DiNuzzo
Publisher: Springer Nature
ISBN: 3030274802
Category : Medical
Languages : en
Pages : 443

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Book Description
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.

Author: Kenneth Maiese
Publisher: Academic Press
ISBN: 0128141190
Category : Medical
Languages : en
Pages : 420

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Book Description
Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings