Combining Simulations, Theory, and Experiments into Multiscale Models of Biological Events PDF Download

Author: Fabio Trovato
Publisher: Frontiers Media SA
ISBN: 2889740250
Category : Science
Languages : en
Pages : 322

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Author: Urs F. Greber
Publisher: Springer
ISBN: 303014741X
Category : Medical
Languages : en
Pages : 235

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Book Description
This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference. Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution. The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

Author: Slavica Jonic
Publisher: Frontiers Media SA
ISBN: 2889456994
Category :
Languages : en
Pages : 128

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Book Description
Models of biomolecular structure and dynamics are often obtained by combining simulation or prediction approaches (e.g., comparative modeling, Molecular Dynamics (MD) simulations, Normal Mode Analysis (NMA), etc.) with experimental approaches (e.g., Nuclear Magnetic Resonance (NMR), X-ray crystallography, Small-Angle X-ray Scattering (SAXS), Electron Microscopy (EM), etc.). Such hybrid modeling extends the capabilities of experimental techniques, by enriching structural information and facilitating dynamics studies of biomolecules. This eBook contains articles on methodological developments, applications, and challenges of hybrid biomolecular modeling that have been collected in the framework of the Frontiers Research Topic entitled “Hybrid Biomolecular Modeling”.

Author: Tamiki Komatsuzaki
Publisher: John Wiley & Sons
ISBN: 1118087828
Category : Science
Languages : en
Pages : 332

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Book Description
This series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 145 in the series continues to report recent advances with significant, up-to-date chapters by internationally recognized researchers.

Author: Vittorio Cristini
Publisher: Cambridge University Press
ISBN: 1139491504
Category : Technology & Engineering
Languages : en
Pages : 299

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Book Description
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Author: Mohd Hafiz Mohd
Publisher: Frontiers Media SA
ISBN: 2832526659
Category : Science
Languages : en
Pages : 133

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Book Description

Author: Dennis R. Salahub
Publisher: Royal Society of Chemistry
ISBN: 1839161787
Category : Science
Languages : en
Pages : 411

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Book Description
Focusing on key methodological breakthroughs in the field, this book provides newcomers with a comprehensive menu of multiscale modelling options.

Author: Ilia A. Solov'yov
Publisher: Springer Nature
ISBN: 3030992918
Category : Science
Languages : en
Pages : 554

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Book Description
This book presents the structure formation and dynamics of animate and inanimate matter on the nanometre scale. This is a new interdisciplinary field known as Meso-Bio-Nano (MBN) science that lies at the intersection of physics, chemistry, biology and material science. Special attention in the book is devoted to investigations of the structure, properties and dynamics of complex MBN systems by means of photonic, electronic, heavy particle and atomic collisions. This includes problems of fusion and fission, fragmentation, surfaces and interfaces, reactivity, nanoscale phase and morphological transitions, irradiation-driven transformations of complex molecular systems, collective electron excitations, radiation damage and biodamage, channeling phenomena and many more. Emphasis in the book is placed on the theoretical and computational physics research advances in these areas and related state-of-the-art experiments. Particular attention in the book is devoted to the utilization of advanced computational techniques and high-performance computing in studies of the dynamics of systems.

Author: Dennis R. Salahub
Publisher: Royal Society of Chemistry
ISBN: 1839164670
Category : Science
Languages : en
Pages : 411

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Book Description
Over the past decade, great strides have been taken in developing methodologies that can treat more and more complex nano- and nano-bio systems embedded in complex environments. Multiscale Dynamics Simulations covers methods including DFT/MM-MD, DFTB and semi-empirical QM/MM-MD, DFT/MMPOL as well as Machine-learning approaches to all of the above. Focusing on key methodological breakthroughs in the field, this book provides newcomers with a comprehensive menu of multiscale modelling options so that they can better chart their course in the nano/bio world.

Author: Mauro Ferrario
Publisher: Springer
ISBN: 3540352732
Category : Science
Languages : en
Pages : 712

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Book Description
This comprehensive collection of lectures by leading experts in the field introduces and reviews all relevant computer simulation methods and their applications in condensed matter systems. Volume 1 is an in-depth introduction to a vast spectrum of computational techniques for statistical mechanical systems of condensed matter. Volume 2 is a collection of state-of-the-art surveys on numerical experiments carried out for a great number of systems.