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Author: Suresh Sahu Publisher: LAP Lambert Academic Publishing ISBN: 9783659448157 Category : Languages : en Pages : 112
Book Description
Malaria is one of the major public health problems in the developing countries. Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. The aim of this study is to develop and characterize a suitable drug delivery system of antimalarial drug for prophylactic use. A depot system for controlled release of antimalarial drug was prepared. Drug loaded heat cross-linked gelatin microspheres were prepared by single emulsion thermal gelation technique. These were characterised by optical microscopy, scanning electron microscopy (SEM), percentage yield (63.20% to 86.13%), drug content (22.95% to 28.02%), encapsulation efficiency (41.46% to 68.26%, differential scanning calorimetry (DSC) and in vitro studies. Size of the microspheres as observed by optical microscopy were 44.06 6.98 um to 54.70 8.19 um, DSC pattern showed absence of drug and polymer interaction. The gelatin microspheres were below 60 um and spherical in shape as evidenced by the SEM photographs. Encapsulated chloroquine diphosphate was released slowly for 24 1 hrs. The study indicated optimum drug release behaviour (84.5% 0.96) in 25 hrs.
Author: Suresh Sahu Publisher: LAP Lambert Academic Publishing ISBN: 9783659448157 Category : Languages : en Pages : 112
Book Description
Malaria is one of the major public health problems in the developing countries. Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. The aim of this study is to develop and characterize a suitable drug delivery system of antimalarial drug for prophylactic use. A depot system for controlled release of antimalarial drug was prepared. Drug loaded heat cross-linked gelatin microspheres were prepared by single emulsion thermal gelation technique. These were characterised by optical microscopy, scanning electron microscopy (SEM), percentage yield (63.20% to 86.13%), drug content (22.95% to 28.02%), encapsulation efficiency (41.46% to 68.26%, differential scanning calorimetry (DSC) and in vitro studies. Size of the microspheres as observed by optical microscopy were 44.06 6.98 um to 54.70 8.19 um, DSC pattern showed absence of drug and polymer interaction. The gelatin microspheres were below 60 um and spherical in shape as evidenced by the SEM photographs. Encapsulated chloroquine diphosphate was released slowly for 24 1 hrs. The study indicated optimum drug release behaviour (84.5% 0.96) in 25 hrs.
Author: Glen S. Kwon Publisher: CRC Press ISBN: 9780824725327 Category : Medical Languages : en Pages : 680
Book Description
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Author: D R Karsa Publisher: Elsevier ISBN: 1845698215 Category : Technology & Engineering Languages : en Pages : 178
Book Description
Encapsulation and controlled release combines basic information on the subject with details of the latest research, making it suitable for both newcomers to the field and those with experience of encapsulation technology. It will also be of great interest to those working on water-soluble or dispersible polymers, as well as application chemists and biochemists in diverse areas.
Author: Heather A. E. Benson Publisher: John Wiley & Sons ISBN: 1119769604 Category : Medical Languages : en Pages : 580
Book Description
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Author: Sougata Jana Publisher: Springer Nature ISBN: 9811502838 Category : Medical Languages : en Pages : 344
Book Description
The book focuses on novel interpenetrating polymer network (IPN)/semi-IPN technologies for drug delivery and biomedical applications. The dynamism of the design and development of interpenetrating network polymers is based on their ability to provide free volume for the easy encapsulation of drugs in the three-dimensional network structure obtained by cross-linking two or more polymer networks. Natural polymer-based IPNs can deliver drugs at a controlled rate over an extended period of time, while novel IPNs ensure better mechanical strength and sustained/ controlled drug-delivery properties. This book presents an overview of the use of this technology to fabricate nanomedicine, hydrogels, nanoparticles, and microparticles, thereby unlocking IPN’s potential in the area of drug delivery and biomedical engineering. It also discusses applications of IPN systems in cancer therapy and tissue engineering, and describes the various IPN systems and their wide usage and applications in drug delivery.
Author: Jorge Coelho Publisher: Springer Science & Business Media ISBN: 9400760108 Category : Medical Languages : en Pages : 433
Book Description
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
Author: Marcos Luciano Bruschi Publisher: Woodhead Publishing ISBN: 0081001126 Category : Medical Languages : en Pages : 208
Book Description
Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Author: Munmaya Mishra Publisher: CRC Press ISBN: 1351019414 Category : Science Languages : en Pages : 2954
Book Description
Undoubtedly the applications of polymers are rapidly evolving. Technology is continually changing and quickly advancing as polymers are needed to solve a variety of day-to-day challenges leading to improvements in quality of life. The Encyclopedia of Polymer Applications presents state-of-the-art research and development on the applications of polymers. This groundbreaking work provides important overviews to help stimulate further advancements in all areas of polymers. This comprehensive multi-volume reference includes articles contributed from a diverse and global team of renowned researchers. It offers a broad-based perspective on a multitude of topics in a variety of applications, as well as detailed research information, figures, tables, illustrations, and references. The encyclopedia provides introductions, classifications, properties, selection, types, technologies, shelf-life, recycling, testing and applications for each of the entries where applicable. It features critical content for both novices and experts including, engineers, scientists (polymer scientists, materials scientists, biomedical engineers, macromolecular chemists), researchers, and students, as well as interested readers in academia, industry, and research institutions.
Author: Suresh Sahu
Author: Suresh Sahu
Author: Glen S. Kwon
Author: Leonard Jan Bruce-Chwatt
Author: D R Karsa
Author: Heather A. E. Benson
Author: Sougata Jana
Author: Jorge Coelho
Author: Marcos Luciano Bruschi
Author: Munmaya Mishra
Author: Rainer H. Müller