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Author: George Casella Publisher: Springer Science & Business Media ISBN: 0387759646 Category : Mathematics Languages : en Pages : 325
Book Description
Statistical design is one of the fundamentals of our subject, being at the core of the growth of statistics during the previous century. In this book the basic theoretical underpinnings are covered. It describes the principles that drive good designs and good statistics. Design played a key role in agricultural statistics and set down principles of good practice, principles that still apply today. Statistical design is all about understanding where the variance comes from, and making sure that is where the replication is. Indeed, it is probably correct to say that these principles are even more important today.
Author: George Casella Publisher: Springer Science & Business Media ISBN: 0387759646 Category : Mathematics Languages : en Pages : 325
Book Description
Statistical design is one of the fundamentals of our subject, being at the core of the growth of statistics during the previous century. In this book the basic theoretical underpinnings are covered. It describes the principles that drive good designs and good statistics. Design played a key role in agricultural statistics and set down principles of good practice, principles that still apply today. Statistical design is all about understanding where the variance comes from, and making sure that is where the replication is. Indeed, it is probably correct to say that these principles are even more important today.
Author: Kamel Rekab Publisher: CRC Press ISBN: 1574446258 Category : Mathematics Languages : en Pages : 257
Book Description
In today's high-technology world, with flourishing e-business and intense competition at a global level, the search for the competitive advantage has become a crucial task of corporate executives. Quality, formerly considered a secondary expense, is now universally recognized as a necessary tool. Although many statistical methods are available for determining quality, there has been no guide to easy learning and implementation until now. Filling that gap, Statistical Design of Experiments with Engineering Applications, provides a ready made, quick and easy-to-learn approach for applying design of experiments techniques to problems. The book uses quality as the main theme to explain various design of experiments concepts. The authors examine the entire product lifecycle and the tools and techniques necessary to measure quality at each stage. They explain topics such as optimization, Taguchi's method, variance reduction, and graphical applications based on statistical techniques. Wherever applicable the book supplies practical rules of thumb, step-wise procedures that allow you to grasp concepts quickly and apply them appropriately, and examples that demonstrate how to apply techniques. Emphasizing the importance of quality to products and services, the authors include concepts from the field of Quality Engineering. Written with an emphasis on application and not on bogging you down with the theoretical underpinnings, the book enables you to solve 80% of design problems without worrying about the derivation of mathematical formulas.
Author: Leslie Kish Publisher: John Wiley & Sons ISBN: 0471725188 Category : Mathematics Languages : en Pages : 293
Book Description
The Wiley Classics Library consists of selected books that have become recognized classics in their respective fields. With these new unabridged and inexpensive editions, Wiley hopes to extend the life of these important works by making them available to future generations of mathematicians and scientists. This title addresses those basic aspects of research design which are common to many related fields in the social sciences, health sciences, education, and market research. The work presents a unified approach to a common core of problems of statistical design that exists in all these fields, along with basic similarities in practical solutions. Describing many examples and analogies that are 'portable' from application field to application field, Statistical Design for Research deals with designs that are the primary basis of research studies, but are neglected in most statistical textbooks that tend to concentrate on statistical analysis. This text takes a broader, more general and philosophical view of the statistics for the more fundamental aspects of design than do the standard treatments of experimental design. Extensively illustrated and carefully organized into seven chapters and 44 sections, this book can be readily consulted by research workers or graduate students!
Author: Shein-Chung Chow Publisher: CRC Press ISBN: 9781584889069 Category : Mathematics Languages : en Pages : 352
Book Description
The US Food and Drug Administration's Report to the Nation in 2004 and 2005 indicated that one of the top reasons for drug recall was that stability data did not support existing expiration dates. Pharmaceutical companies conduct stability studies to characterize the degradation of drug products and to estimate drug shelf life. Illustrating how stability studies play an important role in drug safety and quality assurance, Statistical Design and Analysis of Stability Studies presents the principles and methodologies in the design and analysis of stability studies. After introducing the basic concepts of stability testing, the book focuses on short-term stability studies and reviews several methods for estimating drug expiration dating periods. It then compares some commonly employed study designs and discusses both fixed and random batch statistical analyses. Following a chapter on the statistical methods for stability analysis under a linear mixed effects model, the book examines stability analyses with discrete responses, multiple components, and frozen drug products. In addition, the author provides statistical methods for dissolution testing and explores current issues and recent developments in stability studies. To ensure the safety of consumers, professionals in the field must carry out stability studies to determine the reliability of drug products during their expiration period. This book provides the material necessary for you to perform stability designs and analyses in pharmaceutical research and development.
Author: Michael Orshansky Publisher: Springer Science & Business Media ISBN: 0387690115 Category : Technology & Engineering Languages : en Pages : 319
Book Description
Design for Manufacturability and Statistical Design: A Comprehensive Approach presents a comprehensive overview of methods that need to be mastered in understanding state-of-the-art design for manufacturability and statistical design methodologies. Broadly, design for manufacturability is a set of techniques that attempt to fix the systematic sources of variability, such as those due to photolithography and CMP. Statistical design, on the other hand, deals with the random sources of variability. Both paradigms operate within a common framework, and their joint comprehensive treatment is one of the objectives of this book and an important differentation.
Author: Weichung Joe Shih Publisher: CRC Press ISBN: 1000462811 Category : Medical Languages : en Pages : 320
Book Description
Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book’s balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.
Author: Hans-Michael Kaltenbach Publisher: Springer Nature ISBN: 3030696413 Category : Mathematics Languages : en Pages : 281
Book Description
This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.
Author: George Casella
Author: George Casella
Author: Kamel Rekab
Author: Leslie Kish
Author: Ghosh
Author: Charles Lipson
Author: Shein-Chung Chow
Author: Michael Orshansky
Author: Arnold D. Well
Author: Weichung Joe Shih
Author: Hans-Michael Kaltenbach