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Author: Gordon L. Amidon Publisher: CRC Press ISBN: 9780824766108 Category : Science Languages : en Pages : 754
Book Description
This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.
Author: Gordon L. Amidon Publisher: CRC Press ISBN: 9780824766108 Category : Science Languages : en Pages : 754
Book Description
This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.
Author: Gordon L. Amidon Publisher: ISBN: 9780824793746 Category : Languages : en Pages :
Book Description
This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.
Author: Gordon L. Amidon Publisher: CRC Press ISBN: 0824746325 Category : Science Languages : en Pages : 746
Book Description
This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.
Author: Marcos Luciano Bruschi Publisher: Woodhead Publishing ISBN: 0081001126 Category : Medical Languages : en Pages : 208
Book Description
Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Author: Hamid Arastoopour Publisher: Springer ISBN: 9783030685805 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This volume fills the need for a textbook presenting basic governing and constitutive equations, followed by several engineering problems on multiphase flow and transport that are not provided in current advanced texts, monographs, or handbooks. The unique emphasis of this book is on the sound formulation of the basic equations describing multiphase transport and how they can be used to design processes in selected industrially important fields. The clear underlying mathematical and physical bases of the interdisciplinary description of multiphase flow and transport are the main themes, along with advances in the kinetic theory for particle flow systems. The book may be used as an upper-level undergraduate or graduate textbook, as a reference by professionals in the design of processes that deal with a variety of multiphase systems, and by practitioners and experts in multiphase science in the area of computational fluid dynamics (CFD) at U.S. national laboratories, international universities, research laboratories and institutions, and in the chemical, pharmaceutical, and petroleum industries. Distinct from other books on multiphase flow, this volume shows clearly how the basic multiphase equations can be used in the design and scale-up of multiphase processes. The authors represent a combination of nearly two centuries of experience and innovative application of multiphase transport representing hundreds of publications and several books. This book serves to encapsulate the essence of their wisdom and insight, and:
Author: Endre Nagy Publisher: Elsevier ISBN: 0124160255 Category : Science Languages : en Pages : 342
Book Description
With a detailed analysis of the mass transport through membrane layers and its effect on different separation processes, this book provides a comprehensive look at the theoretical and practical aspects of membrane transport properties and functions. Basic equations for every membrane are provided to predict the mass transfer rate, the concentration distribution, the convective velocity, the separation efficiency, and the effect of chemical or biochemical reaction taking into account the heterogeneity of the membrane layer to help better understand the mechanisms of the separation processes. The reader will be able to describe membrane separation processes and the membrane reactors as well as choose the most suitable membrane structure for separation and for membrane reactor. Containing detailed discussion of the latest results in transport processes and separation processes, this book is essential for chemistry students and practitioners of chemical engineering and process engineering. Detailed survey of the theoretical and practical aspects of every membrane process with specific equations Practical examples discussed in detail with clear steps Will assist in planning and preparation of more efficient membrane structure separation
Author: Gus R. Rosania Publisher: Humana ISBN: 9781071612491 Category : Medical Languages : en Pages : 453
Book Description
This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.
Author: Glynn Wilson Publisher: Springer Science & Business Media ISBN: 1475702868 Category : Medical Languages : en Pages : 382
Book Description
In recent years there have been rapid advances in the growth and differentiation of mammalian cells in culture. This has led to increasing use of such in vitro systems in a wide variety of studies on fundamental aspects of cell structure and function, including normal growth and metabolism, mechanisms of differentiation and oncogenesis, mechanisms of protein and membrane synthesis and cell polarity. Recent advances in our ability to grow cells, including human cells, on permeable supports, to generate confluent cellular barriers with the morphological polarity corresponding to their in vivo counterparts has greatly facilitated such studies. In particular these new techniques have led to an increasing interest in the use of cell and tissue culture systems as a means for examining the transport of drugs across epithelial and endothelial barriers. An obvious question is whether these new in vitro methodologies will provide convenient systems that can substitute for and replace animal models. Various research groups both in academia and in the pharmaceutical industry have been investigating these types of methodologies in order to develop convenient well characterized systems that can be used to examine basic aspects of transcellular transport and to evaluate the permeability of drug molecules and delivery systems. Of particular note is use of confluent cell layers to study the transport of large molecules such as peptides and proteins produced through recombinant DNA technology.
Author: Sven Kastens Publisher: Cuvillier Verlag ISBN: 3736964048 Category : Technology & Engineering Languages : en Pages : 190
Book Description
Gas / liquid contact apparatuses are widely used in chemical, biochemical or pharmaceutical industry to provide and transfer gas species as reactant from the gaseous phase to pre-dissolved reactants in the liquid phase enabling a preferred reaction. The global and local transport are complex interlinked processes and therefore in practice in reactor design industry, mostly empirically correlated. For a secure control of the overall process and a more efficient reactor design, the local transport processes at gas / liquid interfaces need to be investigated in complexity reduced systems to be understood. Elongated bubbles, Taylor bubbles, in vertical channels 5.5 < D < 8 mm overcome the problem of dynamic shape deformation, complex 3D rise trajectories and they have a volume independent rise velocity, which make them the ideal experiment for reliable and reproducible investigations. Detailed optical measurements of global and local processes via high-speed Shadowgraphy, 2D2C PIV and p-2D LIF give new insights into the dependency of local bubble shape and global terminal rise velocity, establish a Sherwood correlation of shrinking CO2 bubbles in various channel sizes and shows the coupling of local transport phenomena at the bubble interface and the mixing in the wake region.
Author: Gordon L. Amidon
Author: Gordon L. Amidon
Author: Gordon L. Amidon
Author: Gordon L. Amidon
Author: Marcos Luciano Bruschi
Author: B. A. Callingham
Author: Hamid Arastoopour
Author: Endre Nagy
Author: Gus R. Rosania
Author: Glynn Wilson
Author: Sven Kastens