Author: Peristera Paschou Publisher: Frontiers Media SA ISBN: 2889453235 Category : Languages : en Pages : 324
Book Description
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as histamine and glutamate. For a very long time, efforts to elucidate the etiology and pathophysiology of TS have been fragmented and hampered by low statistical power. Finally, after more than two decades of active research aiming to identify the etiology and pathophysiology of TS, we are on the verge of a new era, promising exciting and rapid discoveries in the field. Investigators from around the world, representing multiple disciplines and scientific approaches, are joining their efforts in large-scale initiatives supported both by European Union and US National funding agencies, such as the European-funded EMTICS, TACTICS, and TSGeneSEE consortia, the Marie Curie Initial Training Network TS-EUROTRAIN and the European Society for the Study of TS joining forces with the NIH-funded TSAICG, GGRI, and Tic Genetics consortia. Importantly, all these initiatives are supported by TS patient support and advocacy groups. Multiple resources are being consolidated and coming together to serve the study of TS, including large well-characterized patient cohorts, and specialized epidemiological databases, such as the unique resource of the Netherlands Twin Register. This research topic showcases current large-scale collaborative efforts aiming to elucidate the genetic and neurobiological background of TS, through diverse approaches; from genomewide association studies aiming to identify common variants associated to the disorder to neuroimaging studies and animal models. Furthermore, current approaches on the clinical assessment and management of the disorder are presented. Propelled by the gradual availability of large scale TS cohorts, novel methodologies, and importantly, sheer enthusiasm by multiple researchers working together across different countries, the new era of the neurobiology of TS holds the promise to identify novel targets for improved therapies.
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as histamine and glutamate. For a very long time, efforts to elucidate the etiology and pathophysiology of TS have been fragmented and hampered by low statistical power. Finally, after more than two decades of active research aiming to identify the etiology and pathophysiology of TS, we are on the verge of a new era, promising exciting and rapid discoveries in the field. Investigators from around the world, representing multiple disciplines and scientific approaches, are joining their efforts in large-scale initiatives supported both by European Union and US National funding agencies, such as the European-funded EMTICS, TACTICS, and TSGeneSEE consortia, the Marie Curie Initial Training Network TS-EUROTRAIN and the European Society for the Study of TS joining forces with the NIH-funded TSAICG, GGRI, and Tic Genetics consortia. Importantly, all these initiatives are supported by TS patient support and advocacy groups. Multiple resources are being consolidated and coming together to serve the study of TS, including large well-characterized patient cohorts, and specialized epidemiological databases, such as the unique resource of the Netherlands Twin Register. This research topic showcases current large-scale collaborative efforts aiming to elucidate the genetic and neurobiological background of TS, through diverse approaches; from genomewide association studies aiming to identify common variants associated to the disorder to neuroimaging studies and animal models. Furthermore, current approaches on the clinical assessment and management of the disorder are presented. Propelled by the gradual availability of large scale TS cohorts, novel methodologies, and importantly, sheer enthusiasm by multiple researchers working together across different countries, the new era of the neurobiology of TS holds the promise to identify novel targets for improved therapies.
Author: Publisher: Academic Press ISBN: 0323910378 Category : Technology & Engineering Languages : en Pages : 402
Book Description
The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four reviews historical background, current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover The genetic basis of Gilles de la Tourette Syndrome, Genome-wide association study of Tourette Syndrome, De Novo mutations in Tourette Syndrome, Animal models for Tourette Syndrome, The neural-immune crosstalk in Tourette syndrome: from immunobiology to epistemology, Functional connectivity in the Gilles de la Tourette Syndrome, and much more. Includes examines of Gilles de la Tourette Syndrome at behavioral, cognitive, clinical, electrophysiological, molecular and genetic levels Provides a comprehensive overview of the neurobiological aspects of Gilles de la Tourette Syndrome Edited and authored by top researchers and clinicians treating Gilles de la Tourette Syndrome
Author: Publisher: Elsevier ISBN: 0323910343 Category : Medical Languages : en Pages : 462
Book Description
The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Volume Three reviews historical background and current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover Tourette syndrome from phenomenology and natural history to neurobiology, Update and Recent progress in the Neurobiology of Tourette Syndrome, Current guidelines and nosology of Tourette syndrome, Neuroimaging applications in Tourette's Syndrome, Clinical and neurodevelopmental brain imaging of Tourette syndrome, Altered Structural Connectivity in Gilles de la Tourette Syndrome, and much more. The last 20?years have seen an exponential growing body of research dedicated to Gilles de la Tourette Syndrome in the understanding of the syndrome's complex genetics and underlying neurobiology. This unprecedented surge in basic and clinical research has resulted in over 3,000 scientific publications. Examines Gilles de la Tourette Syndrome at behavioral, cognitive, clinical, electrophysiological, molecular and genetic levels Provides a comprehensive overview of the neurobiological aspects of Gilles de la Tourette Syndrome Edited and authored by top researchers and clinicians treating the Gilles de la Tourette Syndrome
Author: Publisher: Academic Press ISBN: 9780323910347 Category : Technology & Engineering Languages : en Pages : 0
Book Description
The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Volume Three reviews historical background and current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover Tourette syndrome from phenomenology and natural history to neurobiology, Update and Recent progress in the Neurobiology of Tourette Syndrome, Current guidelines and nosology of Tourette syndrome, Neuroimaging applications in Tourette's Syndrome, Clinical and neurodevelopmental brain imaging of Tourette syndrome, Altered Structural Connectivity in Gilles de la Tourette Syndrome, and much more. The last 20?years have seen an exponential growing body of research dedicated to Gilles de la Tourette Syndrome in the understanding of the syndrome's complex genetics and underlying neurobiology. This unprecedented surge in basic and clinical research has resulted in over 3,000 scientific publications.
Author: Peristera Paschou
Author: 
Author: 
Author: 
Author: 
Author: